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Product FOB Price Min.Order Supply Ability Supplier
C2H3ClO FACTORY SUPPLY CAS 75-36-5 acetyl chloride
Cas No: 75-36-5
USD $ 2.0-2.0 / Kilogram 2 Kilogram 5 Metric Ton/Week Sparrow Chemical Co.,Ltd Contact Supplier
99% purity Acetyl chloride CAS:75-36-5
Cas No: 75-36-5
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Acetyl chloride
Cas No: 75-36-5
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Acetyl Chloride
Cas No: 75-36-5
No Data 1 Metric Ton Metric Ton/Day Nanjing Chemical Material Corp.(NCMC) Contact Supplier
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Cas No: 75-36-5
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Cas No: 75-36-5
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No Data No Data Metric Ton/Day Zouping Mingxing Chemical Co.,Ltd. Contact Supplier
Acetyl chloride
Cas No: 75-36-5
USD $ 3.0-3.0 / Kilogram 1 Kilogram 1-100 Metric Ton/Month Hangzhou Dayangchem Co., Ltd. Contact Supplier
Acetyl Chloride CAS NO.75-36-5
Cas No: 75-36-5
USD $ 1.0-3.0 / Kilogram 1 Kilogram 10 Kilogram/Day Hebei yanxi chemical co.,LTD. Contact Supplier
High quality Acetyl chloride supplier in China
Cas No: 75-36-5
No Data 1 Kilogram 100 Metric Ton/Month Simagchem Corporation Contact Supplier

75-36-5 Usage

General Description

A colorless, fuming liquid with a pungent odor. Density 9.2 lb / gal. Flash point 40°F. Vapor, which is heavier than air, irritates the eyes and mucous membranes. Corrosive to metals and tissue.
Acetyl chloride, CH30CCI, can be prepared by treatment ofacetic acid with various reagents, such as PCl3 SOCl2 or COCI2. It can be prepared by chlorination of acetic anhydride in several different ways, by reaction of methyl chloride with carbon monoxide in the presence of catalysts, by reaction ofketene with HCI, or by partial hydrolysis of 1, 1, l-trichloroethane, Acetyl chloride hydrolyzes in the presence of water to give acetic acid. It reacts with ammonia and amines to give acetamides. Reaction with alcohols gives the corresponding acetate esters. Acetyl chloride will add across unsaturated bonds in the presence ofsuitable catalysts to give halogenated ketones.

Chemical properties

It appears as colorless transparent liquid smoke with irritating smell. It is miscible with ether, acetic acid and benzene.

Chemical Properties

colourless to light yellow liquid with a pungent

Harmful effects and symptoms of poisoning

Acetyl chloride is a kind of stimulant and corrosive with contact with the skin being able to cause burns. Its steam can strongly irritate the eye and mucous membranes. Human’s inhalation of 2 ppm will be able to feel stimulating effect. Short-term exposure to higher concentrations of acetyl chloride may cause death or permanent damage. The poisoning amount of the aquatic animal is estimated to be in the range of 10 to 100 ppm.


Acetic chloride is a colourless to light yellow liquid with a pungent and choking odour. Acetic chloride is highly flammable and reacts violently with DMSO, water, lower alcohols, and amines to generate toxic fumes. Along with air, acetic chloride may form an explosive mixture. It is incompatible with water, alcohols, amines, strong bases, strong oxidising agents, and most common metals. On decomposition when heated, acetic chloride produces carbon monoxide, carbon dioxide, hydrogen chloride, and phosgene.

Dangerous situation

(1) It has corrosive effect against the skin and mucous membranes with strong irritant effect on the eyes.
(2) It is easily flammable with the burning point being 390 ℃ and a greater risk of combustion. Its vapor can form an explosive mixture with air with the explosion limit remaining not be determined. Since the vapor is heavier than air, it can spread to a considerable distance and cause ignition of a source of fire and further propagate the flame back. It can have violent reaction when coming across water and alcohol. When being heated to decomposition, it can release HCl and highly toxic phosgene gas.

Purification Methods

Reflux acetyl chloride with PCl5 for several hours to remove traces of acetic acid, then distil it. Redistil it from one-tenth its volume of dimethylaniline or quinoline to remove free HCl. A.R. quality is freed from HCl by pumping it for 1hour at -78o and distilling it into a trap at -196o. [Beilstein 2 IV 395.] LACHRYMATORY.

Health Hazard

Vapor irritates mucous membranes. Ingestion of liquid or contact with eyes or skin causes severe irritation.


1.   It is a kind of acetylating agent, being used as raw materials for pesticides and medicine, or the intermediates for the manufacturing of water treatment agent ethylidene diphosphate.
2.   It can be used for the analysis of reagents as well as used for the preparation of acetyl derivatives and dyes
3.   It can be used for organic synthesis, dyes and pharmaceutical industries
4.   It can be used as the raw materials of pesticides and pharmaceutical as well as the intermediate for the manufacture of water treatment agent ethylene diphosphate. Moreover, it can also be used for the manufacture of new electroplating complexing agent. Acetyl chloride is an important acetylating agent with the acylation capability being stronger than acetic anhydride. It is widely used in organic synthesis and dyes. It is also the catalyst for the carboxylic acid to have chlorination reaction as well as being used for hydroxyl and amino quantitative analysis.
5.   This product can be used as raw material for organic synthesis, used in the production of pesticides, pharmaceuticals, new electroplating complexing agent, the catalyst for carboxylic acid to have chlorination, acetylation agent, and other kinds of fine organic synthesis intermediates.


Acetylating agent; in testing for cholesterol, determination of H2O in organic liquids.

Production method

Industrial, acetyl chloride can be manufactured through the reaction between ethylene with hydrogen chloride, or the reaction between sodium acetate, sulfur dioxide and chlorine. The laboratory can apply acetic acid, sodium acetate or acetic anhydride to have reaction with a variety of chlorination agents. For example, it can be obtained through the reaction between acetic anhydride with chlorosulfonic acid (or hydrogen chloride, carbon tetrachloride, phosgene); or obtained through the reaction between glacial acetic acid and benzoyl chloride (or silicon tetrachloride, phosphorus trichloride, chlorinated sulfurous acid and phosphorus pentachloride,). OPERATION EXAMPLE 1: Ingredient ratio (molar ratio): glacial acetic acid: phosphorus trichloride = 3: 1.2. Glacial acetic acid was added to the reactor and stirred slowly. Phosphorus trichloride was added drop-wise over 10-15 min at room temperature. The reaction mixture is subjecting to heating to increase reaction temperature and subject to reaction being maintained at 40-50 °C for 0.5 h. The reaction product is static with the separation obtaining crude product of acetyl chloride and the yield of about 70%.
Operation Example 2 Into a 3 L three-necked flask, add 360 g (6 mol) of glacial acetic acid and 552 g of toluene; heat to 50 °C, and add dropwise 510 g (3 mol) of silicon tetrachloride over 30 min. Keep the temperature at 50 ° C to until hydrogen chloride gas stops being released. Then apply fractionation, steam to until the temperature of the top of the column reaches 80-85 ℃ to obtain the crude product. The fine product is further subject to re-distillation. Take the 50-65 °C fractions and obtain 400 g of acetyl chloride with the yield being 85%. Fixed consumption amount of raw materials: glacial acetic acid: 850kg/t, phosphorus trichloride: 1950kg/t.

Physical and chemical properties

It appears as colorless fuming liquid with a strong odor and eye irritation effect. The relative density of 1.1051 (20 ° C), the melting point of-112 ° C, the boiling point of 51-52 ° C and the flash point is 4.4 ° C (closed dish). In the wet air, it can slowly undergo decomposition and give white smoke. When coming across water, it can be violently hydrolyzed into acetic acid and hydrogen chloride, and thus should be sealed for storage. It is miscible with benzene, acetone, chloroform, ether, glacial acetic acid and petroleum ether. Liquid is heavier than water with the vapor being heavier than air. Its chemical nature is lively. It can have metathesis reaction with many compounds. Acetyl chloride can bind to the thiol group in the protein, and therefore being toxic to humans. It is an important kind of acetylation agents with its acylation capability being stronger than acetic anhydride. It is widely used in organic synthesis, being also the catalyst for the chlorination of carboxylic acids. It is manufactured through the mixing of glacial acetic acid and phosphorus trichloride in cold condition with further heating, followed by dehydrochloration distillation.

Reactivity Profile

Acetyl chloride reacts violently with water, steam, methanol or ethanol to form hydrogen chloride and acetic acid. Reacts vigorously with bases, both organic and inorganic. Incompatible with oxidizing agents and alcohols. Produces highly toxic fumes of phosgene gas and chlorine when heated to decomposition [Sax, 9th ed., 1996, p. 35]. Reaction in a confined space with even a small amount of water may cause a violent eruption of gases [Bretherick, 5th ed., 1995, p. 281]. Vapor forms an explosive mixture with air [Kirk-Othmer, 3rd ed., Vol. 1, 1978, p. 162]. Polymerization reaction with dimethyl sulfoxide is particularly violent [Buckley, A., J. Chem. Ed., 1965, 42, p. 674]. May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291].

Hazards & Safety Information

Category Flammable liquids
Toxic grading poisoning
Acute Toxicity Oral-Rat LD50: 910 mg/kg
Dangerous properties of explosives being corrosive to the skin, eyes and mucous membrane;
Flammable and hazardous properties it is flammable in case of fire, high temperature and oxidant; at high temperature, it can be subject to decomposition to release toxic phosgene; it can release toxic chloride when coming across water;
Storage and transportation characteristics Treasury: ventilation, low-temperature and drying; store separately from oxidants and acids;
Extinguishing agent dry powder, dry sand, dry stone powder, carbon dioxide, foam

The main purpose

Acetyl chloride is the most commonly used acetylating agent with reaction with alcohol and phenol generating acetate ether. Its reaction with ammonia can generate acetamide with its interaction with primary amine and secondary amine to generate N-substituted acetamide.
It can be used for the manufacturing of pharmaceutical industry, pesticide manufacturing, acetyl derivatives and dyes. It can be used as the reagents for the determination of phosphorus, cholesterol, water content contained in organic solvents, nitroso, hydroxyl and tetraethyl lead.
Acetyl chloride is the most important acyl halide and can be manufactured through the reaction between glacial acetic acid and thionyl chloride or phosphorus trichloride and phosphorus pentachloride.
The above information is edited by Andy from ChemicalBook.

75-36-5 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
Aldrich (320129)  Acetylchloride  reagent grade, 98% 75-36-5 320129-1KG 1,165.32CNY Detail
Sigma-Aldrich (00990)  Acetylchloride  puriss. p.a., ≥99.0% (T) 75-36-5 00990-1L 2,579.85CNY Detail
Sigma-Aldrich (00990)  Acetylchloride  puriss. p.a., ≥99.0% (T) 75-36-5 00990-250ML 820.17CNY Detail
Sigma-Aldrich (00990)  Acetylchloride  puriss. p.a., ≥99.0% (T) 75-36-5 00990-100ML 451.62CNY Detail
Alfa Aesar (43262)  Acetyl chloride, 99+%    75-36-5 1L 1739.0CNY Detail
Alfa Aesar (43262)  Acetyl chloride, 99+%    75-36-5 250ml 546.0CNY Detail
Alfa Aesar (43262)  Acetyl chloride, 99+%    75-36-5 50ml 235.0CNY Detail
Alfa Aesar (L14013)  Acetyl chloride, 98%    75-36-5 2500ml 846.0CNY Detail
Alfa Aesar (L14013)  Acetyl chloride, 98%    75-36-5 500ml 397.0CNY Detail
Alfa Aesar (L14013)  Acetyl chloride, 98%    75-36-5 25ml 246.0CNY Detail
Alfa Aesar (H32616)  Acetyl chloride, 1M soln. in dichloromethane    75-36-5 500ml 1187.0CNY Detail
Alfa Aesar (H32616)  Acetyl chloride, 1M soln. in dichloromethane    75-36-5 100ml 354.0CNY Detail



According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017


1.1 GHS Product identifier

Product name acetyl chloride

1.2 Other means of identification

Product number -
Other names acetylchloride313

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:75-36-5 SDS

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