148612-11-7

Basic information

• Product Name: N-(5-bromo-2-pyridinyl)propanamide
• Synonyms: N-(5-bromo-2-pyridinyl)propanamide;PROPANAMIDE, N-(5-BROMO-2-PYRIDINYL)-;N-(5-bromopyridin-2-yl)propanamide
• CAS NO: 148612-11-7
• Molecular Formula: C8H9BrN2O
• Molecular Weight: 229.076
• Mol File: 148612-11-7.mol

Chemical Properties

• Boiling Point: 377.9±27.0 °C(Predicted)
• Appearance: /
• Density: 1.543±0.06 g/cm3(Predicted)
• PKA: 12.94±0.70(Predicted)
• CAS DataBase Reference: N-(5-bromo-2-pyridinyl)propanamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(5-bromo-2-pyridinyl)propanamide(148612-11-7)
• EPA Substance Registry System: N-(5-bromo-2-pyridinyl)propanamide(148612-11-7)

Safety Data

• Hazardous Substances Data: 148612-11-7(Hazardous Substances Data)

Upstream product

• 13606-94-5 N-(pyridine-2-yl)propionamide 
• 1072-97-5 5-bromo-2-pyridylamine 
• 123-62-6 propionic acid anhydride 
• 609-02-9 methyl-malonic acid dimethylester 

Downstream Products

• 1314640-67-9 C₃₁H₃₂F₃N₅O₂ 

Relevant articles and documents

Mapping out the synthetic landscape for re-crystallization, co-crystallization and salt formation

In order to examine the balance between co-crystallization and proton transfer in a set of acid-base reactions, molecular electrostatic potential (MEP) surface calculations for substituted pyridines were correlated with their ability to communicate with a series of carboxylic acids via intermolecular interactions in the solid state. The calculated (AM1) charges on the hydrogen-bond acceptor in these N-heterocyclic compounds provide overall excellent guidelines for predicting when a salt or a co-crystal will form. The charges can also be related to the supramolecular yield of the reactions between seven derivatives of 2-aminopyridine and fifteen aromatic/aliphatic carboxylic acids. The outcome of all reactions was screened using IR spectroscopy, and twelve crystal structures were used to verify the spectroscopic assignments and to examine the exact nature of the primary intermolecular interactions.

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1H-PYRAZOLO[3,4-B]PYRIDINES AND THERAPEUTIC USES THEREOF

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Method of producing 2-acyl amino 5-halogenopyridine compounds

A 2-amino-3-nitro-5-halogenopyridine is formed from a 2-acylaminopyridine by way of a 2-acylamino-5-halogenopyridine. The 2-acetamido-5-bromopyridine may be formed from the 2-acylaminopyridine by way of a 2-acylaminopyridinium-HBr3 salt.

Method of producing 2-amino-3-nitro-5-halogenopyridine

A 2-amino-3-nitro-5-halogenopyridine is formed from a 2-acylaminopyridine by way of a 2-acylamino-5-halogenopyridine. The 2-acetamido-5-bromopyridine may be formed from the 2-acylaminopyridine by way of a 2-acylaminopyridinium-HBr3 salt.