Inhalation causes irritation of eyes and respiratory tract. Contact with liquid causes burns of eyes and skin. Ingestion causes burns of mouth and stomach.
Propionic anhydride was previously used in the preparation of α- and β-1-propionyl derivatives of glucopyranose tetra-acetate.
Propionic anhydride reacts exothermically with water. The reactions are sometimes slow, but can become violent when local heating accelerates their rate. Acids accelerate the reaction with water. Incompatible with acids, strong oxidizing agents, alcohols, amines, and bases.
Air & Water Reactions
Decomposes exothermically in water to form a corrosive solution of propionic acid [Merck, 11th ed. 1989].
Shake the anhydride with P2O5 for several minutes, then distil. [Beilstein 2 IV 722.]
colourless liquid with an unpleasant odour
Esterifying agent for certain perfume oils, fats, oils, and especially cellulose. In the production of alkyd resins, dyestuffs and drugs. Has been used as a dehydrating agent in some sulfonations and nitrations.
Propionic anhydride can be synthesized by dehydration of propanoic acid using ketene.
2 CH3CH2CO2H + CH2=C=O → (CH3CH2CO)2O + CH3CO2H
Propionic anhydride is an organic compound with the molecular formula (CH3CH2CO)2O. it is an colorless acid anhydride that is widely used as a reagent in organic synthesis.
Combustible material: may burn but does not ignite readily. Substance will react with water (some violently) releasing flammable, toxic or corrosive gases and runoff. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapors may travel to source of ignition and flash back. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated or if contaminated with water.
Usually used in the preparation of α- and β-1-propionyl derivatives of glucopyranose tetra-acetate.