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123-62-6 Usage

Health Hazard

Inhalation causes irritation of eyes and respiratory tract. Contact with liquid causes burns of eyes and skin. Ingestion causes burns of mouth and stomach.


Propionic anhydride was previously used in the preparation of α- and β-1-propionyl derivatives of glucopyranose tetra-acetate.

Reactivity Profile

Propionic anhydride reacts exothermically with water. The reactions are sometimes slow, but can become violent when local heating accelerates their rate. Acids accelerate the reaction with water. Incompatible with acids, strong oxidizing agents, alcohols, amines, and bases.

Air & Water Reactions

Decomposes exothermically in water to form a corrosive solution of propionic acid [Merck, 11th ed. 1989].

Purification Methods

Shake the anhydride with P2O5 for several minutes, then distil. [Beilstein 2 IV 722.]

Chemical Properties

colourless liquid with an unpleasant odour


Esterifying agent for certain perfume oils, fats, oils, and especially cellulose. In the production of alkyd resins, dyestuffs and drugs. Has been used as a dehydrating agent in some sulfonations and nitrations.


Propionic anhydride can be synthesized by dehydration of propanoic acid using ketene.
2 CH3CH2CO2H + CH2=C=O → (CH3CH2CO)2O + CH3CO2H

General Description

Propionic anhydride is an organic compound with the molecular formula (CH3CH2CO)2O. it is an colorless acid anhydride that is widely used as a reagent in organic synthesis.

Fire Hazard

Combustible material: may burn but does not ignite readily. Substance will react with water (some violently) releasing flammable, toxic or corrosive gases and runoff. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapors may travel to source of ignition and flash back. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated or if contaminated with water.


Usually used in the preparation of α- and β-1-propionyl derivatives of glucopyranose tetra-acetate.



According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017


1.1 GHS Product identifier

Product name Propionic anhydride

1.2 Other means of identification

Product number -
Other names Propanoic acid, anhydride

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. Intermediates
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:123-62-6 SDS

123-62-6Related news

Modification of cassava starch by using Propionic anhydride (cas 123-62-6) and properties of the starch-blended polyester polyurethane09/26/2019

Chemical modification of the cassava starch was conducted through acylation by using propionic anhydride as an esterifying reagent. The reaction was carried out in the presence of a pyridine catalyst and the effects of reaction variables such as the anhydride content, reaction time and reaction ...detailed

Effect of clay content on the morphological, thermo-mechanical and chemical resistance properties of Propionic anhydride (cas 123-62-6) treated jute fiber/polyethylene/nanoclay nanocomposites09/10/2019

Nanoclay is considered potential nanofiller for the manufacturing of natural fiber nanocomposites. The hydrophilic nature of natural fibers affects negatively its adhesion to hydrophobic polymer matrix. In the present study, propionic anhydride (PA) treated jute were used for the manufacturing o...detailed

Atom efficient Friedel–Crafts acylation of toluene with Propionic anhydride (cas 123-62-6) over solid mesoporous superacid UDCaT-509/09/2019

Friedel–Crafts acylation is ubiquitous in industry and is typically carried out by using more than stoichiometric quantities of homogeneous catalysts. This creates pollution. In this work, acylation of toluene was studied in liquid phase with propionic anhydride with a variety of solid superaci...detailed

Friedel–Crafts acylation of anisole with Propionic anhydride (cas 123-62-6) over mesoporous superacid catalyst UDCaT-509/08/2019

The synthesis of 4-methoxypropiophenone, an intermediate for the production of fine chemicals and pharmaceuticals, was carried out via Friedel–Crafts acylation of anisole with propionic anhydride by using various solid acid catalysts. The reactions were carried out under solvent-free conditions...detailed