Serendipitous discovery of a zidovudine guanidine complex: A superior process for the production of zidovudine
A superior process for the commercial production of zidovudine (AZT) has been developed. It was discovered that an AZT-guanidine complex formed when a crude zidovudine solution was treated with guanidine. This readily precipitated from protic solvents resulting in the exclusion of impurities and permitted the development of a superior isolation and purification of AZT.
Preparation and anti-HIV activity of N-3-substituted thymidine nucleoside analogs
A series of 22 derivatives of AZT substituted at the N-3 position of the thymine base were prepared and evaluated for anti-HIV activity in cell culture (Lai strain of HIV-1 in CEM-c113 cells). The AZT analogs bearing a N- 3 amino group (7), a hydroxyalkyl
Adams, David R.,Perez, Caroline,Maillard, Michel,Florent, Jean-Claude,Evers, Michel,Hénin, Yvette,Litvak, Simon,Litvak, Laura,Monneret, Claude,Grierson, David S.
p. 1550 - 1558
(2007/10/03)
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