148671-42-5

Basic information

• Product Name: 3-(4-Fluorophenyl)-3-oxo-2-(4-pyridinyl)propanenitrile
• Synonyms: 3-(4-Fluorophenyl)-3-oxo-2-(4-pyridinyl)propanenitrile;alpha-(4-Fluorobenzoyl)-4-pyridineacetonitrile
• CAS NO: 148671-42-5
• Molecular Formula: C₁₄H₉FN₂O
• Molecular Weight: 240.2324632
• Mol File: 148671-42-5.mol

Chemical Properties

• Boiling Point: 429.3±40.0 °C(Predicted)
• Appearance: /
• Density: 1.266±0.06 g/cm3(Predicted)
• PKA: 12.50±0.10(Predicted)
• CAS DataBase Reference: 3-(4-Fluorophenyl)-3-oxo-2-(4-pyridinyl)propanenitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-Fluorophenyl)-3-oxo-2-(4-pyridinyl)propanenitrile(148671-42-5)
• EPA Substance Registry System: 3-(4-Fluorophenyl)-3-oxo-2-(4-pyridinyl)propanenitrile(148671-42-5)

Safety Data

• Hazardous Substances Data: 148671-42-5(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
3-(4-Fluorophenyl)-3-oxo-2-(4-pyridinyl)propanenitrile is used as a potential bioactive compound for the development of new drugs. Its unique structure, which includes a phenyl group attached to a pyridine ring, suggests that it may have applications in the synthesis of pharmaceuticals, particularly those targeting specific biological pathways or receptors.
Used in Chemical Research:
3-(4-Fluorophenyl)-3-oxo-2-(4-pyridinyl)propanenitrile is used as a subject of study in chemical research to understand its properties, reactions, and potential applications. 3-(4-Fluorophenyl)-3-oxo-2-(4-pyridinyl)propanenitrile's structure and composition make it an interesting candidate for further investigation, which could lead to the discovery of new chemical reactions or the development of novel materials.
Used in Material Science:
3-(4-Fluorophenyl)-3-oxo-2-(4-pyridinyl)propanenitrile is used as a component in the development of new materials, such as polymers or composites, that could have applications in various industries. 3-(4-Fluorophenyl)-3-oxo-2-(4-pyridinyl)propanenitrile's unique structure and properties may contribute to the creation of materials with specific characteristics, such as improved strength, flexibility, or chemical resistance.

Upstream product

• 66134-67-6 p-fluorobenzoic acid succinimidyl ester 
• 13121-99-8 pyridin-4-ylacetonitrile 

Downstream Products

• 148671-44-7 3-(4-fluorophenyl)-4-(pyridin-4-yl)-1H-pyrazol-5-amine 
• 277747-60-1 5-(4-fluorophenyl)-2-methyl-3-phenylacetylamino-4-(4-pyridyl)pyrazole 
• 277746-28-8 3-(4-fluorophenyl)-5-phenylacetylamino-4-(4-pyridyl)pyrazole 
• 277746-65-3 3-(4-fluorophenyl)-1-methyl-4-(pyridin-4-yl)-1H-pyrazol-5-amine 

Relevant articles and documents

Design and synthesis of 5-[(2-chloro-6-fluorophenyl)acetylamino]-3-(4- fluorophenyl)-4-(4-pyrimidinyl)isoxazole (AKP-001), a novel inhibitor of p38 MAP kinase with reduced side effects based on the antedrug concept

Inhibitors of p38 mitogen-activated protein (MAP) kinase, which are closely involved in the production of inflammatory cytokines, are considered promising curative drugs for chronic inflammatory disorders. However, there is also a growing concern regarding its systemic side effects. To reduce the occurrence of side effects, we have identified a novel p38 MAP kinase inhibitor that shows properties of an antedrug, which imparts its effect solely on the inflammatory site and is metabolically inactivated right after. We have designed isoxazole derivatives through the addition of a fresh interacting fourth site to the structure of the prototypical p38 MAP kinase inhibitor that harbors three point interactive sites. The derivative 26d (AKP-001) shows excellent p38 MAP kinase inhibitory activity and a high selectivity for various kinases. Its rapid metabolism has been confirmed in rats. Moreover, 26d has been shown to be effective in animal models of inflammatory bowel disease.

Aminopyrazole derivatives

Aminopyrazole derivatives represented by formula (I), or salts thereof, wherein X1and X2are each a hydrogen atom or a halogen atom, or X1and X2may be united together to form a lower alkylenedioxy group, Q is a p

3-(heteroaryl)-pyrazololi[1,5-a]pyrimidines

This invention relates to heterocyclic derivatives useful for inhibiting the production of Interleukin-1 (IL-1) and tumor necrosis factor (TNF) and the like, which can be represented by the following formula: STR1 to a process for their production, to a pharmaceutical composition containing the same and to uses thereof.