148838-69-1

Basic information

• Product Name: ethyl 5-methyl-4-oxo-2-phenyl-3,4-dihydrothieno[2,3-d]pyrimidine-6-carboxylate
• Synonyms: ethyl 5-methyl-4-oxo-2-phenyl-3,4-dihydrothieno[2,3-d]pyrimidine-6-carboxylate
• CAS NO: 148838-69-1
• Molecular Formula: C₁₆H₁₄N₂O₃S
• Molecular Weight: 314.35896
• Mol File: 148838-69-1.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: ethyl 5-methyl-4-oxo-2-phenyl-3,4-dihydrothieno[2,3-d]pyrimidine-6-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 5-methyl-4-oxo-2-phenyl-3,4-dihydrothieno[2,3-d]pyrimidine-6-carboxylate(148838-69-1)
• EPA Substance Registry System: ethyl 5-methyl-4-oxo-2-phenyl-3,4-dihydrothieno[2,3-d]pyrimidine-6-carboxylate(148838-69-1)

Safety Data

• Hazardous Substances Data: 148838-69-1(Hazardous Substances Data)

Upstream product

• 4815-30-9 diethyl 5-amino-3-methyl-2,4-thiophenedicarboxylate 

Downstream Products

• 148838-71-5 4-Chloro-5-methyl-2-phenyl-thieno[2,3-d]pyrimidine-6-carboxylic acid ethyl ester 

Relevant articles and documents

THIENOPYRIMIDINE DERIVATIVE

This invention provides thienopyrimidine derivatives of the formula, wherein R1 stands for hydrogen atom, an alkyl group or the like; R2 stands for a hydrogen atom, an alkyl or amino group or the like, R3 stands for an alkyl, alkenyl or alkylthio group or the like or a group Y-X-; or R2 and R3 may together form tetramethylene group; X standing for a direct bond or linking group such as CH2, CH(OH), S, O, NH; Y standing for a substituted or unsubstituted aromatic carbocycylic, aromatic heterocylic, cycloalkyl or saturated heterocyclic group or the like; Z stands for S or O, and n is 0 or an integer of 1 to 4, or salts thereof, which exhibit an inhibitory effect on PDE9, and are therefore useful for prevention or treatment of overactive bladder syndrome, pollakiuria, urinary incontinence, dysuria associated with prostatic hyperplasia, urolithiasis, Alzheimer's disease, chronic obstructive pulmonary disease, myocardial infarction, thrombosis, diabetes and the like.

New thieno compounds. Part 14: Synthesis of 4 amino-substituted thieno[2,3-d]pyrimidine-6-carboxylic acid derivatives

The combination of a basic and a carboxylic ester group in the thieno[2,3-d]pyrimidine structure could give interesting biological activities. Starting from the diester of 2-amino-4-methylthiophene-3,5-diacid the ethylesters of 3,4-dihydro-5-methyl-4-oxot