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4815-30-9

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4815-30-9 Usage

Chemical Properties

slightly yellow to beige-yellow crystalline powder

Uses

Diethyl 5-Amino-3-methylthiophene-2,4-dicarboxylate is used as a reagent in the synthesis of novel pyrazolo-pyrimidinones as dipeptidyl peptidase IV (DPP-IV) inhibitors in diabetes. It is also used in the synthesis of N-phenylthieno[2,3-d]pyrimidin-4-amines which act as inhibitors of fibroblast grow factor receptor 1 and therefore may be further used as anticancer agents.

Check Digit Verification of cas no

The CAS Registry Mumber 4815-30-9 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,8,1 and 5 respectively; the second part has 2 digits, 3 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 4815-30:
(6*4)+(5*8)+(4*1)+(3*5)+(2*3)+(1*0)=89
89 % 10 = 9
So 4815-30-9 is a valid CAS Registry Number.
InChI:InChI=1/C11H15NO4S/c1-4-15-10(13)7-6(3)8(17-9(7)12)11(14)16-5-2/h4-5,12H2,1-3H3

4815-30-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-Amino-3,5-Bis(Ethoxycarbonyl)-4-Methylthiophene

1.2 Other means of identification

Product number -
Other names diethyl 5-amino-3-methylthiophene-2,4-dicarboxylate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:4815-30-9 SDS

4815-30-9Relevant articles and documents

Triester-amide based on thiophene and ricinoleic acid as an innovative primary plasticizer for poly(vinyl chloride)

Satavalekar, Sneha D.,Savvashe, Prashant B.,Mhaske, Shashank T.

, p. 115101 - 115112 (2016)

It is necessary to replace phthalate plasticizers which are used in PVC as they are found to be carcinogenic and hazardous to human health. They can be substituted with other bio based plasticizers which are non toxic. We have synthesized a triester amide of thiophene (THPRABA) with ricinoleic acid (RA) and benzoic acid (BA) reacting with a diester derivative of 2-aminothiophene (THP) which itself is procured by using Gewald multicomponent synthesis. The structure of the THPRABA was confirmed by IR, 1H NMR, acid value, and hydroxyl value. The DOP was replaced entirely by THPRABA as a plasticizer for PVC in all samples with a varying proportion of THPRABA from 10 phr to 50 phr with a fixed heat stabilizer content as 5 phr. The incorporation of THPRABA shows a decrease in tensile and mechanical properties, glass transition temperature (Tg), crystallinity and shore hardness properties. The yellowness index shows darkening of PVC sheets with a decrease in whiteness. Hence it can replace DOP in plasticizer application successfully in some application areas of PVC.

Efficient synthesis of new thieno[2,3-d]pyrimidin-4(3H)-one derivatives for evaluation as anticancer agents

Hu, Yang-Gen,Zheng, Ai-Hua,Li, Gao-Jun,Dong, Meng-Zhu,Ye, Fang,Sun, Feng,Liu, Zheng-Yun,Li, Wen

, p. E84-E88 (2014)

Thieno[2,3-d]pyrimidinones were reported to act as potent anticancer agents; in this work, a series of new substituted thieno[2,3-d]pyrimidinone (6) were synthesized via the aza-Wittig reaction in satisfactory yields. The structures of these compounds were confirmed by elemental analysis, IR, 1H-NMR, and mass spectral data, and compound 6h was further analyzed by single crystal X-ray diffraction. Cytotoxic effect of all the compounds was carried out on human breast and lung cancer cell lines (MCF-7 and SPC-A-1, A459). Compound 6f exhibited the best inhibition activities against A459 with IC50 4.1 μM.

Molecular design, synthesis and in vitro biological evaluation of thienopyrimidine–hydroxamic acids as chimeric kinase HDAC inhibitors: a challenging approach to combat cancer

Abdel-Atty, Mona M.,Abouzid, Khaled A. M.,Farag, Nahla A.,Mowafy, Samar,Serya, Rabah A. T.

, p. 1290 - 1312 (2021/07/09)

A series of thieno[2,3-d]pyrimidine-based hydroxamic acid hybrids was designed and synthesised as multitarget anti-cancer agents, through incorporating the pharmacophore of EGFR, VEGFR2 into the inhibitory functionality of HDAC6. Three compounds (12c, 15b and 20b) were promising hits, whereas (12c) exhibited potent VEGFR2 inhibition (IC50=185 nM), potent EGFR inhibition (IC50=1.14 μM), and mild HDAC6 inhibition (23% inhibition). Moreover, compound (15c) was the most potent dual inhibitor among all the synthesised compounds, as it exhibited potent EGFR and VEGFR2 inhibition (IC50=19 nM) and (IC50=5.58 μM), respectively. While compounds (20d) and (7c) displayed nanomolar selective kinase inhibition with EGFR IC50= 68 nM and VEGFR2 IC50= 191 nM, respectively. All of the synthesised compounds were screened in vitro for their cytotoxic effect on 60 human NCI tumour cell lines. Additionally, molecular docking studies and ADMET studies were carried out to gain further insight into their binding mode and predict the pharmacokinetic properties of all the synthesised inhibitors.

COMPOUNDS, COMPOSITIONS, AND METHODS FOR MODULATING ANDROGEN RECEPTOR ACTIVITY

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Page/Page column 13; 46; 47, (2020/07/15)

Inhibitors of androgen receptors that are thienopyrimidine derivatives corresponding to formula (I), and salts thereof, and associated compositions and methods of treatment:

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