Synthesis and characterization of a series of isoniazid hydrazones. Spectroscopic and theoretical study
A family of hydrazones of isoniazid and a group of hydroxybenzalaldehydes (vanillin, 5-bromovanillin, 5-chlorosalicylaldehyde and 5-bromosalicylaldehyde) were obtained and fully characterized. The results, including theoretical data, are comparatively ana
Ferraresi-Curotto, Verónica,Echeverría, Gustavo A.,Piro, Oscar E.,Pis-Diez, Reinaldo,González-Baró, Ana C.
From Dynamic Combinatorial Chemistry to in Vivo Evaluation of Reversible and Irreversible Myeloperoxidase Inhibitors
The implementation of dynamic combinatorial libraries allowed the determination of highly active reversible and irreversible inhibitors of myeloperoxidase (MPO) at the nanomolar level. Docking experiments highlighted the interaction between the most activ
Isonicotinohydrazones as inhibitors of alkaline phosphatase and ecto-5′-nucleotidase
A series of isonicotinohydrazide derivatives was synthesized and tested against recombinant human and rat ecto-5′-nucleotidases (h-e5′NT and r-e5′NT) and alkaline phosphatase isozymes including both bovine tissue-non-specific alkaline phosphatase (b-TNAP)
Synthesis and characterization of (E)-N′-(substituted benzylidene)isonicotinohydrazide derivatives as potent antimicrobial and hydrogen peroxide scavenging agents
A series of (E)-N′-(substituted benzylidene)isonicotinohydrazide derivatives were synthesized by coupling isoniazid with differently substituted aldehydes and benzophenones in the presence of absolute ethanol along with catalytic amount of glacial acetic
Malhotra, Manav,Sharma, Gaurav,Deep, Aakash
experimental part
p. 637 - 644
(2012/08/29)
Synthesis, characterization and pharmacological evaluation of (E)-N′-(substituted-benzylidene)isonicotinohydrazide derivatives as potent anticonvulsant agents
A series of (E)-N′-(substituted-benzylidene)isonicotinohydrazide derivatives were synthesized by coupling it with different substituted aldehydes, acetophenone, and benzophenones in presence of absolute ethanol along with catalytic amount of glacial aceti
Synthesis, characterization of (E)-N'-(substituted-benzylidene) isonicotinohydrazide derivatives as potent antitubercular agents
A series of 19 isonicotinic acid hydrazide derivatives has been synthesized and evaluated for their in vitro antitubercular activity against Mycobacterium tuberculosis H37Rv using alamar blue susceptibility test. The synthesized comp
Malhotra, Manav,Sharma, Rajiv,Monga, Vikramdeep,Deep, Aakash,Sahu, Kapendra,Samad, Abdul
experimental part
p. 575 - 579
(2012/06/01)
Studies on isoniazide derivatives. Preparation and antimicrobial activity of 2-aryl-3-(pyridylcarbomyl)-5-carboxymethyl-4-thiazolidinones