149-17-7

Basic information

• Product Name: Ftivazide
• Synonyms: Ftivazide;phthivazid;4-pyridinecarboxylic acid, ((4-hydroxy-3-methoxyphenyl)methylene)hydrazide;ftivazid;Isonicotinic acid vanillylidenehydrazide;isonicotinic acid, vanillylidenehydrazide;phtivazid;vanicid
• CAS NO: 149-17-7
• Molecular Formula: C₁₄H₁₃N₃O₃
• Molecular Weight: 271.275
• Mol File: 149-17-7.mol
• Article Data: 7

Chemical Properties

• Melting Point: 219-220 °C
• Boiling Point: 414.36°C (rough estimate)
• Flash Point: 220.9°C
• Appearance: /
• Density: 1.2122 (rough estimate)
• Vapor Pressure: 5.36E-08mmHg at 25°C
• Refractive Index: 1.5700 (estimate)
• PKA: 8.65±0.35(Predicted)
• CAS DataBase Reference: Ftivazide(CAS DataBase Reference)
• NIST Chemistry Reference: Ftivazide(149-17-7)
• EPA Substance Registry System: Ftivazide(149-17-7)

Safety Data

• Hazardous Substances Data: 149-17-7(Hazardous Substances Data)

Usage

Uses

Isonicotinic Acid Vanillylidenehydrazide exhibits anti-mycobacterial activity against Mycobacterium tuberculosis and anti-microbial activity against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Candida albicans, and Aspergillus niger.Also, it is derived from Isoniazid (I821450), which is an antibiotic for treatment of Mycobacterium tuberculosis, inhibits mycolic acid biosynthesis. Metabolized by hepatic N-acetyltransferase (NAT) and cytochrome P450 2E1 (CYP2E1) to form hepatotoxins. Selectively induces expression of CYP2E1. Reversibly inhibits CYP2C19 and CYP3A4 activities, and mechanistically inactivates CYP1A2, CYP2A6, CYP2C19 and CYP3A4 at clinically relevant concentrations. Antibacterial (tuberculostatic).

InChI:InChI=1/C14H13N3O3/c1-20-13-8-10(2-3-12(13)18)9-16-17-14(19)11-4-6-15-7-5-11/h2-9,16H,1H3,(H,17,19)/b10-9+

Upstream product

• 54-85-3 isoniazid 
• 121-33-5 vanillin 
• 1570-45-2 isonicotinic acid ethylester 

Relevant articles and documents

Synthesis and characterization of a series of isoniazid hydrazones. Spectroscopic and theoretical study

A family of hydrazones of isoniazid and a group of hydroxybenzalaldehydes (vanillin, 5-bromovanillin, 5-chlorosalicylaldehyde and 5-bromosalicylaldehyde) were obtained and fully characterized. The results, including theoretical data, are comparatively ana

Isonicotinohydrazones as inhibitors of alkaline phosphatase and ecto-5′-nucleotidase

A series of isonicotinohydrazide derivatives was synthesized and tested against recombinant human and rat ecto-5′-nucleotidases (h-e5′NT and r-e5′NT) and alkaline phosphatase isozymes including both bovine tissue-non-specific alkaline phosphatase (b-TNAP)

Synthesis, characterization and pharmacological evaluation of (E)-N′-(substituted-benzylidene)isonicotinohydrazide derivatives as potent anticonvulsant agents

A series of (E)-N′-(substituted-benzylidene)isonicotinohydrazide derivatives were synthesized by coupling it with different substituted aldehydes, acetophenone, and benzophenones in presence of absolute ethanol along with catalytic amount of glacial aceti