1491165-31-1

Upstream product

• 661487-18-9 tert-butyl 3-phenyl-6,7-dihydro-1H-pyrazolo[4,3-c]pyridine-5(4H)-carboxylate 
• 41979-39-9 4-piperidone hydrochloride 
• 2493-02-9 4-bromophenyl isocyanate 
• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 
• 1491164-90-9 C₁₉H₁₇BrN₄O 
• 2719-27-9 cyclohexanylcarbonyl chloride 
• 87628-50-0 3-phenyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine 

Relevant academic research and scientific papers

Development of 3-phenyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine derivatives as novel Mycobacterium tuberculosis pantothenate synthetase inhibitors

Forty 3-phenyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine derivatives were synthesized from piperidin-4-one by five step synthesis and evaluated for Mycobacterium tuberculosis (MTB) pantothenate synthetase (PS) inhibition study, in vitro activities against MTB, cytotoxicity against RAW 264.7 cell line. Among the compounds, 1-benzoyl-N-(4-nitrophenyl)-3-phenyl-6,7-dihydro-1H-pyrazolo[4, 3-c]pyridine-5(4H)-carboxamide (6ac) was found to be the most active compound with IC50 of 21.8 ± 0.8 μM against MTB PS, inhibited MTB with MIC of 26.7 μM and it was non-cytotoxic at 50 μM.