87628-50-0Relevant academic research and scientific papers
Identification of a new class of HBV capsid assembly modulator
Kuduk, Scott D.,Stoops, Bart,Alexander, Richard,Lam, Angela M.,Espiritu, Christine,Vogel, Robert,Lau, Vincent,Klumpp, Klaus,Flores, Osvaldo A.,Hartman, George D.
, (2021/04/12)
The HBV core protein is a druggable target of interest due to the multiple essential functions in the HBV life cycle to enable chronic HBV infection. The core protein oligomerizes to form the viral capsid, and modulation of the HBV capsid assembly has sho
Development of 3-phenyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine derivatives as novel Mycobacterium tuberculosis pantothenate synthetase inhibitors
Samala, Ganesh,Devi, Parthiban Brindha,Nallangi, Radhika,Yogeeswari, Perumal,Sriram, Dharmarajan
, p. 356 - 364 (2013/10/21)
Forty 3-phenyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine derivatives were synthesized from piperidin-4-one by five step synthesis and evaluated for Mycobacterium tuberculosis (MTB) pantothenate synthetase (PS) inhibition study, in vitro activities against MTB, cytotoxicity against RAW 264.7 cell line. Among the compounds, 1-benzoyl-N-(4-nitrophenyl)-3-phenyl-6,7-dihydro-1H-pyrazolo[4, 3-c]pyridine-5(4H)-carboxamide (6ac) was found to be the most active compound with IC50 of 21.8 ± 0.8 μM against MTB PS, inhibited MTB with MIC of 26.7 μM and it was non-cytotoxic at 50 μM.
