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149231-65-2

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A substrate combinatorial array for caspases
An efficient strategy for the synthesis of a tetrapeptidyl substrate combinatorial array directed toward the caspases is described. Testing of this array with caspases 1 and 4 gave substrate hydrolytic profiles characteristic of each caspase, and permitted the identification of efficiently processed substrates. A comparison of this approach to that using a positional scanning library is presented.
Lee, Dennis,Adams, Jerry L.,Brandt, Martin,DeWolf Jr., Walter E.,Keller, Paul M.,Levy, Mark A.
p. 1667 - 1672
(2007/10/03)

Amino acids and peptides. XL. Synthesis of Ac-Tyr-Val-Ala-Asp-MCA using newly developed acetylating reagent
2-Acetoxy-3-benzyl-5-methyl-6-isobutylpyrazine was prepared by cyclization of H-Phe-Leu-CH2Cl, followed by acetylation with acetic anhydride. This pyrazine derivative can react with amino groups of amino acids or peptides to produce acetyl amin
Taguchi,Hirano,Yokoi,Asada,Okada
p. 1336 - 1339
(2007/10/02)

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26093-31-2
7-amino-4-methylcoumarin.

Chemical Properties

Appearance/Colour :white powder
Boiling Point: 1127.3 °C at 760 mmHg
Flash Point:635.6 °C
Density: 1.344 g/cm³
Solubility:DMSO: 10 mM The solution is stable in the dark at −20
Storage Temp.:−20°C
PSA: 233.24000
LogP: 2.73450

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