14945-93-8Relevant articles and documents
Combining hit identification strategies: Fragment-based and in silico approaches to orally active 2-aminothieno[2,3-d]pyrimidine inhibitors of the Hsp90 molecular chaperone
Brough, Paul A.,Barril, Xavier,Borgognoni, Jenifer,Chene, Patrick,Davies, Nicholas G. M.,Davis, Ben,Drysdale, Martin J.,Dymock, Brian,Eccles, Suzanne A.,Garcia-Echeverria, Carlos,Fromont, Christophe,Hayes, Angela,Hubbard, Roderick E.,Jordan, Allan M.,Jensen, Michael Rugaard,Massey, Andrew,Merrett, Angela,Padfield, Antony,Parsons, Rachel,Radimerski, Thomas,Raynaud, Florence I.,Robertson, Alan,Roughley, Stephen D.,Schoepfer, Joseph,Simmonite, Heather,Sharp, Swee Y.,Surgenor, Allan,Valenti, Melanie,Walls, Steven,Webb, Paul,Wood, Mike,Workman, Paul,Wright, Lisa
supporting information; experimental part, p. 4794 - 4809 (2010/03/01)
Inhibitors of the Hsp90 molecular chaperone are showing considerable promise as potential molecular therapeutic agents for the treatment of cancer. Here we describe novel 2-aminothieno[2,3-d]pyrimidine ATP competitive Hsp90 inhibitors, which were designed
Solution- and solid-phase synthesis of combinatorial libraries of trisubstituted 1,3,5-triazines
Masquelin, Thierry,Meunier, Nathalie,Gerber, Fernand,Rosse, Gerard
, p. 2489 - 2505 (2007/10/03)
A general synthesis of trisusbstituted 1,3,5-triazines of types (4) and (5) by condensation of amidines (2) and thiouronium salts (3) with dimethyl cyanoiminodithiocarbonate (1) was first established in solution (Scheme 1). Further investigations were dir
Reactions with N-Acylimino-dithiocarbonic-acid-diesters
Augustin, M.,Richter, M.,Salas, S.
, p. 55 - 68 (2007/10/02)
Reactions of N-acylimino-dithiocarbonic-acid-S,S-diesters 1 with nucleophilic compounds present new possibilities to synthesize heterocycles.With amines 1a reacts by mono- and disubstitution, respectively, of methylthio-groups to isothioureas 2 and guanidines 3, with 1,2-binucleophilic arenes to benzoheterocycles 4, with aliphatic diamines to imidazolines 5, pyrimidines 6, diazepines 7 and the hexamethylene-diamine-derivatives 8. 1a reacts also with hydrazines to 1,2,4-triazoles 9 and with hydrazides to the thiosemicarbazones 10 or 1,3,4-oxadiazoles 11.Heterocyclisations of 1 with guanidines, thiourea, salts of thiourea and amidines give the 1,3,5-triazines 12, 14, 15 and 16.N-benzoyl-dithiocarbonic-acid-methylester -amid reacts with CH-acidic compounds to thiazoles 17.The structures of the final products are determined by i.r.-, 1H-n.m.r.-, u.v.- and mass-spectras.
