113-00-8Relevant articles and documents
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Schmidt
, (1917)
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Sabetta,Himmelfarb,Smith
, p. 2478 (1935)
Watt, G. W.,Hahn, H. T.
, p. 312 - 317 (1955)
Total synthesis of (±)-batzelladine K: A biomimetic approach
Ahmed, Nafees,Brahmbhatt, Keyur G.,Singh, Inder Pal,Bhutani, Kamlesh K.
, p. 2567 - 2570 (2010)
Total synthesis of batzelladine K was achieved by a biomimetic approach. The key reactions involve two Wittig reactions of phosphoranes and aldehydes leading to an ,-unsaturated ketone, followed by a condensation with guanidine. The synthesis was accomplished in four steps with an overall yield of 12%. The relative stereochemistry of batzelladine K was established by NOE experiments and comparison with literature values. Georg Thieme Verlag Stuttgart - New York.
Preparation and Properties of Substituted 1,6-Dihydro-1,3,5-triazin-2,4-diamines, 1',5',6',7'-Tetrahydrospiro-2'(3'H)-imines and 6-Phenyl-2,4-pyrimidindiamine
Wendelin, Winfried,Zmoelnig, Ilse,Schramm, Hans-Wolfgang
, p. 1189 - 1202 (1980)
Guanidine reacts with cyclohexanone, cycloheptanone, acetone and 3-pentanone, resp., in a molar ratio 2:1 to give the 1,3,5-triazaspiroundeca- and dodeca-1,3-dien-2,4-diamines 3a and 3b resp. and the 6,6-dimethyl- resp. diethyl-1,6-dihydro-1,3,5-triazin-2,4-diamines 3d and 3e resp.On the contrary, action of guanidine on cyclpentanone yields not 3c, but the 1',5',6',7'-tetrahydrospiro-2'(3'H)-imines 2c, 5c and 6c resp., which are 1:2- and 1:3-condensates.Phenylacetone is transformed by guanidine (1:2) to give 6-phenyl-2,4-pyrimidindiamine (8f).The structure of the compounds cited is proved by NMR-, IR-, and (partially) mass spectra.The different courses of the formation of 3a, b, d, e, 2c, 5c and 6c resp. and 8f are also discussed.The structural formulae of some additional bases, which were synthesized from guanidine and cyclopentanone, 3-pentanone and phenylacetone resp. could not be established. - Keywords: Guanidine, reactions with ketones; Ketones, reactions with guanidine; 2,4-Pyrimidindiamine, 6-phenyl; Spiro-2'(3'H)-imine, 1',5',6',7'-tetrahydro; 1,3,5-Triazaspiroundeca- and dodeca-1,3-dien-2,4-diamine; 1,3,5-Triazine-2,4-diamines, 1,6-dihydro-6,6-dialkyl, and salts
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Boivin
, p. 1467,1470 (1955)
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Insertion of Diazo Esters into C-F Bonds toward Diastereoselective One-Carbon Elongation of Benzylic Fluorides: Unprecedented BF3Catalysis with C-F Bond Cleavage and Re-formation
Wang, Fei,Nishimoto, Yoshihiro,Yasuda, Makoto
supporting information, p. 20616 - 20621 (2021/11/23)
Selective transformation of C-F bonds remains a significant goal in organic chemistry, but C-F insertion of a one-carbon-atom unit has never been established. Herein we report the BF3-catalyzed formal insertion of diazo esters as one-carbon-atom sources into C-F bonds to accomplish one-carbon elongation of benzylic fluorides. A DFT calculation study revealed that the BF3 catalyst could contribute to both C-F bond cleavage and re-formation. This elongation provided α-fluoro-α,β-diaryl esters with a high level of diastereoselectivity. Various benzylic fluorides and diazo esters were applicable. The synthetic utility of this method was demonstrated by the synthesis of a fluoro analogue of a compound that is used as a transient receptor and potential canonical channel inhibitor.
Guanidyl luteolin-chrome (III) complex and preparation method thereof
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Paragraph 0013; 0016; 0017; 0022, (2019/10/17)
The invention discloses a guanidyl luteolin-chrome (III) complex and a preparation method thereof. Luteolin is taken as a raw material, and the guanidyl luteolin-chrome (III) complex is prepared by free radical reaction, nucleophilic substitution reaction and trivalent chromium complexation. The production process is simple, the cost is low, and the large-scale industrial production of the guanidyl luteolin-chrome (III) complex is facilitated.
Hydrogen sulfide donor in organic salt form and preparation method thereof
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Paragraph 0026; 0027, (2017/12/09)
The invention provides a hydrogen sulfide donor in an organic salt form and a preparation method thereof. The hydrogen sulfide donor is a salt structure formed by organic compounds with an alkaline structure and hydrogen sulfide. The structure of the hydrogen sulfide donor is simple. The preparation method is simple and easy to perform. Moreover, hydrogen sulfide donors in different forms can be obtained according to the needs of development and research. After the hydrogen sulfide donor enters an organism, the process of degradation in the organism and hydrogen sulfide supply is simple, rapid, and effective, there is not any requirement on enzyme or other complicated condition, and thus the hydrogen sulfide donor has a wide application prospect and a great application value.
