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2,6-DIMETHOXY-BETA-NITROSTYRENE is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 149488-96-0 Structure
  • Basic information

    1. Product Name: 2,6-DIMETHOXY-BETA-NITROSTYRENE
    2. Synonyms: 2,6-DIMETHOXY-BETA-NITROSTYRENE, >95%
    3. CAS NO:149488-96-0
    4. Molecular Formula: C10H11NO4
    5. Molecular Weight: 209.2
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 149488-96-0.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 2,6-DIMETHOXY-BETA-NITROSTYRENE(CAS DataBase Reference)
    10. NIST Chemistry Reference: 2,6-DIMETHOXY-BETA-NITROSTYRENE(149488-96-0)
    11. EPA Substance Registry System: 2,6-DIMETHOXY-BETA-NITROSTYRENE(149488-96-0)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 149488-96-0(Hazardous Substances Data)

149488-96-0 Usage

Type of compound

Beta-nitrostyrene derivative

Structural features

Contains two methoxy groups on the phenyl ring

Use in research

Precursor for the synthesis of various pharmaceuticals and organic compounds

Biological activity

Exhibits moderate cytotoxic and antiproliferative activity, potential candidate for cancer treatments

Potential use

Precursor for the synthesis of new psychoactive substances

Status

Not approved for therapeutic or commercial use

Handling precautions

Should be handled with caution in a laboratory setting.

Check Digit Verification of cas no

The CAS Registry Mumber 149488-96-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,9,4,8 and 8 respectively; the second part has 2 digits, 9 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 149488-96:
(8*1)+(7*4)+(6*9)+(5*4)+(4*8)+(3*8)+(2*9)+(1*6)=190
190 % 10 = 0
So 149488-96-0 is a valid CAS Registry Number.

149488-96-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 2,6-DIMETHOXY-β-NITROSTYRENE

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:149488-96-0 SDS

149488-96-0Downstream Products

149488-96-0Relevant articles and documents

Microwave-assisted rapid synthesis of spirooxindole-pyrrolizidine analogues and their activity as anti-amyloidogenic agents

de Silva, Nilamuni H.,Pyreddy, Suneela,Blanch, Ewan W.,Hügel, Helmut M.,Maniam, Subashani

, (2021)

A library of Sox-pyrrolizidines was rapidly prepared by microwave-assisted, one-pot, three-component, 1,3-dipolar cycloaddition of azomethine ylides from l-proline and isatin, with various β-nitrostyrenes. Nitro-Sox compounds, 4b, 4d and 4e inhibit HEWL amyloid fibril formation by ThT studies with percentages of fluorescence intensity of 55.4, 42.9 and 40.3%, respectively. Further studies with MTT assay, Raman spectroscopy, TEM and molecular docking supported these promising candidates for activity against amyloid misfolding, a phenomenon leading to Alzheimer's disease pathology.

Synthesis and Functional Characterization of 2-(2,5-Dimethoxyphenyl)-N-(2-fluorobenzyl)ethanamine (25H-NBF) Positional Isomers

Pottie, Eline,Kupriyanova, Olga V.,Shevyrin, Vadim A.,Stove, Christophe P.

, p. 1667 - 1673 (2021/05/31)

Serotonergic psychedelics, substances exerting their pharmacological action through activation of the serotonin 2A receptor (5-HT2AR), have continuously comprised a substantial fraction of the over 1000 reported New Psychoactive Substances (NPS) so far. Within this category, N-benzyl derived phenethylamines, such as NBOMes and NBFs, have shown to be of particular relevance. As these substances remain incompletely characterized, this study aimed at synthesizing positional isomers of 25H-NBF, with two methoxy groups placed on different positions of the phenyl group of the phenethylamine moiety. These isomers were then functionally characterized in an in vitro bioassay monitoring the recruitment of β-Arrestin 2 to the 5-HT2AR through luminescent readout via the NanoBiT technology. The obtained results provide insight into the optimal substitution pattern of the phenyl group of the phenethylamine moiety of N-benzyl derived substances, a feature so far mostly explored in the phenethylamines underived at the N-position. In the employed bioassay, the most potent substances were 24H-NBF (EC50 value of 158 nM), 26H-NBF (397 nM), and 25H-NBF (448 nM), with 23H-NBF, 35H-NBF, and 34H-NBF yielding μM EC50 values. A similar ranking was obtained for the compounds' efficacy: Taking as a reference LSD (lysergic acid diethylamide), 24H-, 26H-, and 25H-NBF had an efficacy of 106-107%, followed by 23H-NBF (96.1%), 34H-NBF (75.2%), and 35H-NBF (58.9%). The stronger activity of 24H-, 25H-, and 26H-NBF emphasizes the important role of the methoxy group at position 2 of the phenethylamine moiety for the in vitro functionality of NBF substances.

Pd-catalyzed cross-coupling of carboxylic acids with nitroethane via combination of decarboxylation and dehydrogenation

Zhang, Min,Zhou, Jun,Kan, Jian,Wang, Min,Su, Weiping,Hong, Maochun

supporting information; experimental part, p. 5455 - 5457 (2010/10/04)

An unexpected coupling reaction of arene carboxylic acid with nitroethane via a combination of decarboxylation and dehydrogenation is described. The method provides exclusively (E)-β-nitrostyrenes. The Royal Society of Chemistry 2010.

An efficient synthesis of conjugated nitro-olefins using ceric ammonium nitrate

Sridhar Rao,Srinivas,Suresh Babu,Madhusudana Rao

, p. 8141 - 8143 (2007/10/03)

An efficient method for the synthesis of conjugated nitro-olefins from α,β-unsaturated acids under extremely mild conditions using ceric ammonium nitrate (CAN) at room temperature in acetonitrile in moderate to good yields is described.

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