149507-27-7

Basic information

• Product Name: 4-(1,4-DIOXASPIRO[4,5]DEC-8-YL) BENZONITRILE
• Synonyms: 4-(1,4-DIOXASPIRO[4,5]DEC-8-YL) BENZONITRILE
• CAS NO: 149507-27-7
• Molecular Formula: C₁₅H₁₇NO₂
• Molecular Weight: 243.3
• Mol File: 149507-27-7.mol

Chemical Properties

• Boiling Point: 401.1°Cat760mmHg
• Flash Point: 148.3°C
• Appearance: /
• Density: 1.17g/cm³
• Vapor Pressure: 1.22E-06mmHg at 25°C
• Refractive Index: 1.568
• CAS DataBase Reference: 4-(1,4-DIOXASPIRO[4,5]DEC-8-YL) BENZONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(1,4-DIOXASPIRO[4,5]DEC-8-YL) BENZONITRILE(149507-27-7)
• EPA Substance Registry System: 4-(1,4-DIOXASPIRO[4,5]DEC-8-YL) BENZONITRILE(149507-27-7)

Safety Data

• Hazardous Substances Data: 149507-27-7(Hazardous Substances Data)

Usage

InChI:InChI=1/C15H17NO2/c16-11-12-1-3-13(4-2-12)14-5-7-15(8-6-14)17-9-10-18-15/h1-4,14H,5-10H2

Upstream product

• 107-21-1 ethylene glycol 
• 73204-07-6 4-(4-cyanophenyl)cyclohexanone 
• 4894-75-1 1-phenyl-4-cyclohexanone 
• 73204-06-5 4-(4-oxocyclohexyl)benzamide 

Downstream Products

• 25163-93-3 8-phenyl-1,4-dioxaspiro[4,5]decane 
• 1276024-99-7 C₁₅H₁₈O₃ 
• 1276024-98-6 1-(1H-benzo[d]imidazol-5-yl)-5-(4-(4-oxocyclohexyl)phenyl)imidazolidin-2-one 
• 73204-07-6 4-(4-cyanophenyl)cyclohexanone 

Relevant articles and documents

NOVEL BRONCHODILATING DIAZAHETEROARYLS

The invention relates to novel compounds having the general formula (I), and which compounds are useful to treat a disorder or disease characterized by bronchoconstriction, e.g. COPD and asthma.

NOVEL INHIBITORS

The invention relates to novel pyrrolidine derivatives of formula (I): wherein R1, R2 and R3 are as defined herein, as inhibitors of glutaminyl cyclase (QC, EC 2.3.2.5). QC catalyzes the intramolecular cyclization of N-terminal glutamine residues into pyroglutamic acid (5-oxo-prolyl, pGlu*) under liberation of ammonia and the intramolecular cyclization of N-terminal glutamate residues into pyroglutamic acid under liberation of water.

NOVEL BRONCHODILATING DIAZAHETEROARYLS

The invention relates to novel compounds having the general formula (I), and which compounds are useful to treat a disorder or disease characterized by bronchoconstriction, e.g. COPD and asthma.

4-AZETIDINYL-1-PHENYL-CYCLOHEXANE ANTAGONISTS OF CCR2

The present invention comprises compounds of Formula (I): wherein: X, R1, R2, R3, and R4 are as defined in the specification. The invention also comprises a method of preventing, treating or ameliorating a syndrome, disorder or disease, wherein said syndrome, disorder or disease is type II diabetes, obesity and asthma. The invention also comprises a method of inhibiting CCR2 activity in a mammal by administration of a therapeutically effective amount of at least one compound of Formula (I).

Cyclic imino derivatives and pharmaceutical compositions containing them

The invention relates to cyclic imino compounds which have, inter alia, valuable pharmacological properties, especially inhibitory effects on cell aggregation, pharmaceutical compositions which contain these compounds and processes for preparing them.