- Xanthine derivatives
-
A novel xanthine derivative of the formula (I): STR1 wherein one of R1 and R2 represents substituted or unsubstituted lower alkyl, lower alkenyl, lower alkynyl, substituted or unsubstituted alicyclic alkyl, substituted or unsubstitut
- -
-
-
- Xanthine derivatives
-
A xanthine derivative of the formula (I): STR1 wherein R1 represents substituted or unsubstituted lower alkyl, lower alkenyl, lower alkynyl, substituted or unsubstituted alicyclic alkyl, substituted or unsubstituted phenyl, or substituted or unsubstituted benzyl; R2 represents --(CH2)m --X, wherein m is 2 or 3, and X is STR2 wherein a is NH, O or S, b and d are the same or different and are CH or N, and R3 is lower alkyl, substituted or unsubstituted alicyclic alkyl, or substituted or unsubstituted phenyl, or STR3 wherein e, g and h are the same or different and are CH or N, and R3 is the same as defined above; Q represents substituted or unsubstituted alicyclic alkyl, STR4 wherein R4 and R5 are the same or different and are substituted or unsubstituted alicyclic alkyl, STR5 wherein Y is single bond or alkylene; and n is 0 or 1, STR6 wherein K-M is --CH2 --CH2 --or --CH=CH--, and Y is the same as defined above, or STR7 wherein Y is the same as defined above; or a pharmacologically acceptable salt thereof is disclosed. This derivative has anti-dementia activity.
- -
-
-
- Adenosine A1 antagonists. 3. Structure-activity relationships on amelioration against scopolamine- or N6-((R)-phenylisopropyl)adenosine-induced cognitive disturbance.
-
The effects of a variety of adenosine A1 and A2 antagonists on N6-((R)-phenylisopropyl)adenosine (R-PIA)- and scopolamine-induced amnesias were investigated in rodents in order to clarify the role of adenosine receptors in learning and memory. Some of the
- Suzuki,Shimada,Shiozaki,Ichikawa,Ishii,Nakamura,Nonaka,Kobayashi,Fuse
-
p. 2508 - 2518
(2007/10/02)
-