16200-53-6Relevant articles and documents
Compounds with urotropin structure. XLVII. A new synthesis of 1,2- and 2,6-disubstituted adamantanes
Stetter,Thomas,Meyer
, p. 863 - 867 (1970)
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Discovery of adamantane based highly potent HDAC inhibitors
Gopalan, Balasubramanian,Ponpandian, Thanasekaran,Kachhadia, Virendra,Bharathimohan, Kuppusamy,Vignesh, Radhakrishnan,Sivasudar, Velaiah,Narayanan, Shridhar,Mandar, Bhonde,Praveen, Rajendran,Saranya, Nithyanandan,Rajagopal, Sriram,Rajagopal, Sridharan
, p. 2532 - 2537 (2013/06/27)
Herein, we report the development of highly potent HDAC inhibitors for the treatment of cancer. A series of adamantane and nor-adamantane based HDAC inhibitors were designed, synthesized and screened for the inhibitory activity of HDAC. A number of compounds exhibited GI50 of 10-100 nM in human HCT116, NCI-H460 and U251 cancer cells, in vitro. Compound 32 displays efficacy in human tumour animal xenograft model.
SYNTHESIS OF 3-NORADAMANTAMINE
Jawdosiuk, Mikolaj,Kovacic, Peter
, p. 53 - 62 (2007/10/02)
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