- Synthesis of pyridone and pyridine rings by [4+2] hetero-cyclocondensation
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Substituted pyridones and pyridines have been synthesised efficiently by employing iminium salt as a key precursor. These compounds were prepared using tandem [4+2] cycloaddition/deamination between azabutadiene and dienophiles.
- Robin, Aélig,Julienne, Karine,Meslin, Jean Claude,Deniaud, David
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- Pyrimidinium compound, and preparation method and application thereof
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The invention relates to a pyrimidinium compound, and a preparation method and an application thereof, and concretely relates to a pyrimidinium compound represented by formula (B2-A) or a stereoisomer, a nitrogen oxide and a salt thereof, an application of the above compounds as insecticides in agriculture, a form of an insecticide composition of the compound, and a method for controlling pests byusing the compounds or the composition. In the formula (B2-A), U, L, R, R, R, R, R, R, R, o and w have the meanings described in the invention.
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Paragraph 0317; 0318
(2020/06/05)
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- Furanone derivatives, preparation method and use thereof
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The invention relates to a novel selective cyclooxygenase-2 inhibitor compound, a preparation method and use and belongs to the field of chemical drugs. The compound represented by a formula (I) shown in the description can be used for inhibiting cyclooxy
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Paragraph 0191; 0192; 0195; 0196
(2019/05/04)
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- INDOLE AND AZAINDOLE HALOALLYLAMINE DERIVATIVE INHIBITORS OF LYSYL OXIDASES AND USES THEREOF
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The present invention relates to novel compounds which are capable of inhibiting certain amine oxidase enzymes. These compounds are useful for treatment of a variety of indications, e.g., fibrosis, cancer and/or angiogenesis in human subjects as well as i
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Paragraph 0291
(2017/09/05)
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- NITROGEN-CONTAINING HETEROCYCLIC COMPOUND HAVING INHIBITORY EFFECT ON PRODUCTION OF KYNURENINE
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The present invention provides a nitrogen-containing heterocyclic compound or a pharmaceutically acceptable salt thereof having an inhibitory effect on the production of kynurenine, represented by formula (I): (wherein R6 and R7 may be the same or different and each represent a hydrogen atom or the like, R8, R9, R19, and R11 may be the same or different and each represent a hydrogen atom or the like, R1 represents lower alkyl which may be substituted with cycloalkyl, or the like, and R3 represents optionally substituted aryl or an optionally substituted heterocyclic group).
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Paragraph 0213
(2013/03/28)
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- Substituted dipyridylethenes and -ethynes and key pyridine building blocks
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Various new 2,5-disubstituted pyridines were prepared. The 2-substituted 5-formylpyridines 8, 15a-b were obtained by reduction of the nicotinic acid 3, hydrolysis of the bis(morpholino)methylpyridine 6 or the reaction of 5-bromopyridines 12 and 14 with lithium butoxide in DMF. Dipyridylethenes 16a-b,e were synthesized by Wadsworth-Emmons reaction with pyridyl phosphonate 7 or by coupling of the aldehydes by McMurry reaction to the ethenes 16c-d. After bromination of the C = C double bond of the dipyridylethenes 16a-d, dipyridylacetylenes 18a-d were obtained via elimination of the 1,2-dipyridyl-1,2-dibromoethanes 17a-d.
- Windscheif,Vogtle
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