149978-42-7

Basic information

• Product Name: 1-Methyl-5-(trifluoromethyl)-1H-pyrazol-3-amine
• Synonyms: 1-Methyl-5-(trifluoromethyl)-1H-pyrazol-3-amine;3-Amino-1-methyl-5-(trifluoromethyl)-1H-pyrazole;1-METHYL-5-(TRIFLUOROMETHYL)-1H-PYRAZOL-;3-amino-5-trifluoromethyl-N-methyl pyrazole
• CAS NO: 149978-42-7
• Molecular Formula: C₅H₆F₃N₃
• Molecular Weight: 165.1164496
• Mol File: 149978-42-7.mol

Chemical Properties

• Boiling Point: 227.9±40.0 °C(Predicted)
• Appearance: /
• Density: 1.50±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C(protect from light)
• PKA: 2.82±0.11(Predicted)
• CAS DataBase Reference: 1-Methyl-5-(trifluoromethyl)-1H-pyrazol-3-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Methyl-5-(trifluoromethyl)-1H-pyrazol-3-amine(149978-42-7)
• EPA Substance Registry System: 1-Methyl-5-(trifluoromethyl)-1H-pyrazol-3-amine(149978-42-7)

Safety Data

• Hazardous Substances Data: 149978-42-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
1-Methyl-5-(trifluoromethyl)-1H-pyrazol-3-amine is used as a building block for the synthesis of potential drug candidates due to its chemical stability and lipophilicity, which can enhance the bioavailability and efficacy of the resulting pharmaceutical compounds.
Used in Agrochemical Industry:
1-Methyl-5-(trifluoromethyl)-1H-pyrazol-3-amine is used as a building block for the synthesis of agricultural chemicals, leveraging its potential as a pesticide and its ability to be chemically stable in various environmental conditions.
Used in Medicinal Research:
1-Methyl-5-(trifluoromethyl)-1H-pyrazol-3-amine is used as a research tool for studying its biological and pharmacological activities, including its inhibitory effects on certain enzymes, which can lead to the discovery of new therapeutic agents.
Used in Enzyme Inhibition Studies:
1-Methyl-5-(trifluoromethyl)-1H-pyrazol-3-amine is used as an enzyme inhibitor in biological assays to understand its potential as a therapeutic agent, particularly in conditions where enzyme regulation is critical.
Used in Pesticide Development:
1-Methyl-5-(trifluoromethyl)-1H-pyrazol-3-amine is used in the development of pesticides due to its pesticidal properties, offering a new avenue for creating effective and stable agrochemicals.

Upstream product

• 481065-92-3 1-methyl-5-(trifluoromethyl)-1H-pyrazole-3-carboxylic acid 
• 128648-60-2 (3E)-4-amino-4-ethoxy-1,1,1,trifluoro-3-buten-2-one 
• 302-15-8 methylhydrazine sulfuric acid 
• 110234-68-9 3-cyano-1,1,1-trifluoroacetone 
• 60-34-4 methylhydrazine 

Downstream Products

• 1229453-99-9 N-(1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)-5-((6-((methylamino)methyl)pyrimidin-4-yl)oxy)-1H-indole-1-carboxamide 
• 1188909-55-8 phenyl (1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)carbamate 
• 1620678-56-9 (4-((1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)carbamoyl)phenyl)boronic acid 

Relevant articles and documents

Practical synthetic method for functionalized 1-methyl-3/5-(trifluoromethyl)-1H-pyrazoles

A new, high-yielding, and practical method for synthesis of 1-methyl-3-(trifluoromethyl)-1H-pyrazole and 1-methyl- 5-(trifluoromethyl)-1H-pyrazole, key intermediates for important building blocks relevant to medicinal and agrochemistry, is developed. A one-step procedure for synthesis of the regioisomeric mixture of target pyrazoles was proposed starting from 4-ethoxy- 1,1,1-trifluoro-3-buten-2-one. The procedure for separation of this mixture was elaborated on the basis of the boiling point vs pressure diagram analysis. The efficient synthetic strategies for regioisomeric building blocks bearing CF3 groups at the 3rd and 5th positions were demonstrated. A set of 1-methyl-3-(trifluoromethyl)-1H-pyrazoles containing such a functional group as aldehyde, acid, boron pinacolate, lithium sulfinate, and sulfonyl chloride was synthesized based on lithiation of 1-methyl-3-(trifluoromethyl)- 1H-pyrazole in a flow reactor. Bromination of both 1-methyl-3-(trifluoromethyl)-1H-pyrazole and 1-methyl-5-(trifluoromethyl)-1Hpyrazole by NBS in mild conditions was performed. The introduction of the functional group at the 4th position of 1-methyl-5- (trifluoromethyl)-1H-pyrazole was illustrated by the optimized synthesis of the corresponding aldehyde and acid based on the Br-Li exchange in an appropriate bromide. Alternatively, the introduction of the functional group (acid and boron pinacolate) at the 5th position of 1-methyl-5-(trifluoromethyl)-1H-pyrazole was performed based on the direct ortho-metalation (DoM) reaction of 4- bromo-1-methyl-5-(trifluoromethyl)pyrazole followed by catalytic reductive debromination.

PYRAZOLE-SUBSTITUTED PYRROLIDINONES AS HERBICIDES

Disclosed are compounds of Formula (1), including all stereoisomers, N-oxides, and salts thereof, wherein Q is selected from the group consisting of and R1, R2, R3, Y, R4, R5, n, R6, W and

SULFONYLUREAS AND RELATED COMPOUNDS AND USE OF SAME

ABSTRACT The present invention provides for certain sulfonyl ureas and related compounds which have advantageous properties and show useful activity in the inhibition of activation of the NLRP3 inflammasome. Such compounds are useful in the treatment of a wide range of disorders in which the inflammation process, or more specifically the NLRP3 inflammasome, have been implicated as being a key factor.

PYRIDAZINONE GLUCOKINASE ACTIVATORS

Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of metabolic diseases and disorders such as, for example, type II diabetes mellitus.

Substituted pyrazolypyrazoles and their use as herbicides

STR1 The invention relates to new pyrazolylpyrazoles of general formula (I) in which R1, R2, R3, R4 and R5 have the meanings given in the description, processes for their preparation as well as intermediates, and their use as herbicides.