- METHODS AND COMPOSITIONS FOR TREATING DISEASES AND CONDITIONS
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Provided herein include methods and compositions for treating diseases or conditions. In some embodiments provided are methods for treating one or more diseases or conditions selected from the group consisting of hypertension, heart failure, dyspnea, and
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Paragraph 189; 190
(2016/01/25)
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- Methods of Using Diaminopyrimidine P2X3 and P2X 2/3 Receptor Modulators for Treatment of Acute and Sub-Acute Cough, Urge to Cough and Chronic Cough, in Respiratory Diseases
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Methods for treating cough, chronic cough and urges to cough associated with respiratory diseases with a P2X3 and/or a P2X2/3 receptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a compound of Formu
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Paragraph 0171; 0172
(2015/03/04)
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- Identification and SAR of novel diaminopyrimidines. Part 2: The discovery of RO-51, a potent and selective, dual P2X3/P2X2/3 antagonist for the treatment of pain
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The purinoceptor subtypes P2X3 and P2X2/3 have been shown to play a pivotal role in models of various pain conditions. Identification of a potent and selective dual P2X3/P2X2/3 diaminopyrimidine antagonist RO-4
- Jahangir, Alam,Alam, Muzaffar,Carter, David S.,Dillon, Michael P.,Bois, Daisy Joe Du,Ford, Anthony P.D.W.,Gever, Joel R.,Lin, Clara,Wagner, Paul J.,Zhai, Yansheng,Zira, Jeff
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scheme or table
p. 1632 - 1635
(2009/10/15)
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- Diaminopyrimidines as P2X3 and P2X2/3 modulators
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Compounds of formula (I): wherein R1 and R2 are as defined herein. Also disclosed are methods of making and using the subject compounds.
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Page/Page column 19
(2008/12/08)
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- Process for synthesis of phenoxy diaminopyrimidine derivatives
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A method for preparing a compound of formula I the method comprising treating a compound of formula d with an iodination reagent, to form the compound of formula I, wherein R1, R2 and R3 are as defined herein.
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Page/Page column 19; 21-22
(2010/11/26)
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- Novel photolabile protecting group for carbonyl compounds
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Equation presented A novel type of photo-protecting group for carbonyl compounds is described. The protecting group is readily accessed in one step from commercially available material. Installation of the protecting group upon the carbonyl compounds is achieved in excellent yields. The carbonyl compounds in their protected form are remarkably stable under various conditions and can be released photochemically in high efficiency.
- Pengfei, Wang,Huayou, Hu,Yun, Wang
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p. 1533 - 1535
(2008/02/02)
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- Methods of using diaminopyrimidine P2X3 and P2X2/3 receptor modulators for treatment of respiratory and gastrointestinal diseases
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Methods for treating respiratory and gastrointestinal diseases mediated by a P2X3 and/or a P2X2/3 receptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein D, X, Y, R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein.
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Page/Page column 92
(2010/11/26)
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- Diaminopyrimidines as P2X3 and P2X2/3 antagonists
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Compounds and methods for treating diseases mediated by a P2X3 and/or a P2X2/3 receptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a compound of formula (I): or a pharmaceutically acceptable salt, solvate or prodrug thereof, wherein D, X, Y, R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein.
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Page/Page column 100
(2010/02/14)
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