- Enantiomeric Recognition of d - And l -Lactate by CEST with the Aid of a Paramagnetic Shift Reagent
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A previous report demonstrated that EuDO3A could be used as an NMR shift reagent for imaging extracellular lactate produced by cancer cells using CEST imaging. In this work, a series of heptadentate macrocyclic YbDO3A-trisamide complexes with δ-chiral car
- Zhang, Lei,Martins, André F.,Zhao, Piyu,Tieu, Michael,Esteban-Gómez, David,McCandless, Gregory T.,Platas-Iglesias, Carlos,Sherry, A. Dean
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- The synthesis of new amphiphilic p-tert-butylthiacalix[4]arenes containing peptide fragments and their interaction with DNA
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New water-soluble p-tert-butylthiacalix[4]arenes containing peptide and quaternary ammonium fragments in cone and 1,3-alternate conformations were synthesized and characterized. The interaction of the macrocycles with DNA was studied by UV-spectroscopy, DLS and TEM. It was shown that the interaction of the self-associates based on p-tert-butylthiacalix[4]arenes tetrasubstituted at the lower rim with glycine and quaternary ammonium fragments in cone and 1,3-alternate conformations with DNA led to the formation of particles of about 99-192 nm in size.
- Padnya, Pavel L.,Andreyko, Elena A.,Mostovaya, Olga A.,Rizvanov, Ildar Kh.,Stoikov, Ivan I.
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- Synthesis and organogelating behaviour of amino acid-functionalised triphenylenes
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Four novel amino acid-functionalised triphenylenes have been prepared with glycine, l-alanine, l-phenylalanine and l-tryptophan ethyl ester side-chains. The glycine derivative is a good gelator of chloroform, the alanine derivative gels ethanol and toluene, and the phenylalanine derivative gels benzene and toluene. The tryptophan derivative does not gel any of the solvents tested, most probably due to its more bulky structure, but forms microspheres by evaporation-induced self-assembly. The self-assembly properties of the π-gelators have been investigated using infrared, UV-absorption and fluorescence spectroscopy, concentration- and temperature-dependent NMR, and X-ray scattering experiments on dried xerogel as well as the wet organogel. The latter experiments suggest the glycine gel in chloroform includes columnar aggregates, with an overall disordered columnar oblique mesophase. These compounds are of interest because of the well-known hole-transporting properties of triphenylene liquid crystals: 1-D columnar assemblies of these compounds may find applications in organic electronic devices.
- Meegan, Jonathan E.,Yang, Xiaofei,Rungsirisakun, Ratana,Cosgrove, Sebastian C.,Bushby, Richard J.,Sadeghpour, Amin,Rappolt, Michael,Brydson, Rik,Ansell, Richard J.
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Read Online
- Site-Tunable Csp3 -H Bonds Functionalization by Visible-Light-Induced Radical Translocation of N-Alkoxyphthalimides
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Site-tunable functionalization of C(sp3)-H bonds has been accomplished through radical translocation and cross-coupling. Upon irradiation with visible light, copper-based photocatalyst [Cu(Xantphos)(dmp)]BF4 enabled cross-coupling of N-alkoxyphthalimides with amino acid esters or amino acids to provide δ-C(sp3)-H alkylated alcohols (31 examples, up to 92% yield) with additive BNDHP or α-C(sp3)-H alkylated alcohols (18 examples, up to 86% yield) with additive DABCO in a highly regioselective fashion.
- Wang, Chuanyong,Yu, Yangyang,Liu, Wen-Long,Duan, Wei-Liang
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supporting information
p. 9147 - 9152
(2019/11/14)
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- A 4 - phenyl quinoline compound, preparation method and application thereof (by machine translation)
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The invention discloses a 4 - phenyl quinoline compound, its preparation method and application, the invention of the 4 - phenyl quinoline compound to, its structure (I) shown in the diimmonium: Wherein R1 Is - OH, - Cl, - OCH3 Or -
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Paragraph 0073
(2017/08/31)
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- A silver triflate-catalyzed cascade of in situ-oxidation and allylation of arylbenzylamines
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A silver-triflate catalyzed cascade of in situ-oxidation and allylation of arylbenzylamines is reported. The 2,2,6,6-tetramethylpiperidine-1-oxoammonium tetrafluoroborate is employed as a mild oxidant which is compatible with both catalyst and ligand. Racemic BINAP is also utilized to assist with the catalyst in regulating the yields of products. Various homoallylic amines are obtained in 39–99% yields.
- Wang, Junjiao,Yang, Shangdong
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supporting information
p. 3444 - 3448
(2016/07/18)
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- Enantioselective synthesis of arylglycine derivatives by direct C-H oxidative cross-coupling
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A new method for the synthesis of chiral α-amino acid derivatives by enantioselective C-H arylation of N-aryl glycine esters with aryl boric acids in the presence of a chiral Pd(ii)-catalyst has been developed. This work successfully integrates the direct C-H oxidation with asymmetric arylation and exhibits excellent enantioselectivity. This journal is
- Wei, Xiao-Hong,Wang, Gang-Wei,Yang, Shang-Dong
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supporting information
p. 832 - 835
(2015/02/05)
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- Amphiphilic EuDOTA-tetraamide complexes form micelles with enhanced CEST sensitivity
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The synthesis and characterization of four new DOTA-tetraamide ligands having variable alkyl chain lengths (C1, C12, C 14, and C16) and their respective europium(III) complexes are reported. The three EuL comple
- Evbuomwan, Osasere M.,Kiefer, Garry,Sherry, A. Dean
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experimental part
p. 2126 - 2134
(2012/06/15)
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- Binding Properties of Amide and Amide-Ester N-Functionalised Polyaza Macrocycles
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A series of amide and amide-ester N-functionalised coronands has been prepared based on -N2O2, -N2O3 and -N2O4 polyazaoxa macrocycles.Complexation of certain alkali and alkaline-earth metal cations has been monitored by 13C NMR and IR spectroscopy, enthalpies of complexation measured in methanolic solution by calorimetry and stability constants measured in aqueous solution by potentiometric methods.Strong complexation of Ca2+ in aqueous solution was observed with high selectivities (ca. 102 to 103.5) over Na+ and K+.
- Kataky, Ritu,Parker, David,Teasdale, Andrew,Hutchinson, Jonathan P.,Buschmann, Hans-J.
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p. 1347 - 1351
(2007/10/02)
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