- Highly selective synthesis of α-bromoesters using molecular bromine catalyzed by phosphorus
-
A series of α-bromoesters have been synthesized by applying Hell-Volhard-Zelinsky reaction catalyzed by phosphorus instead of usual phosphorus tribromide. An excellent regioselectivity to good yields are achieved at comparatively mild reaction conditions of an operational simplicity.
- Sun, Zhaoyun,Peng, Xinhua,Dong, Xiongzi,Shi, Wenwen
-
scheme or table
p. 929 - 930
(2012/07/30)
-
- A matrix isolation study of the photochemically induced reactions of nitrogen dioxide with 1,2-dibromoethene and 1,2-dichloroethene using Fourier transform infrared spectroscopy
-
Photolyses of matrices of either BrCHCHBr/NO2/Ar or ClCHCHCl/NO2/Ar using quartz-filtered radiation (λ > 240 nm) led to the appearance of infrared bands attributable to carbonyl, carbon monoxide, and ketene species; no bands belonging to a precursor complex NO 2...XCHCHX (where X = Br or Cl) were observed upon matrix deposition. The possible reaction pathway is discussed.
- Clark, Robin J.H.,Foley, Loraine J.
-
p. 1389 - 1393
(2007/10/03)
-
- Method of synthesizing optically enriched alpha-halo-esters, and product and composition therefrom
-
A method of synthesizing highly optically enriched alpha-halo-esters comprises reacting acid halides with a cinchona alkaloid catalyst and a base to form intermediate ketenes. The ketenes are reacted with electrophilic halogenating reagents to produce alpha-halo-esters with high enantiomeric excess. The base can be an inorganic salt. The thus-formed alpha-halo-esters have utility in synthesizing other optically-pure materials.
- -
-
-
- Specific isotope enrichment of methyl methacrylate
-
A synthetic scheme has been developed to prepare methyl methacrylate specifically 13C-labelled at all different positions and in any combination of positions, from simple, commercially available starting materials. According to this scheme methyl (1-13C) and methyl (2-13C)methacrylate (1a and 1b) have been prepared with high label incorporation (99%).
- Werkhoven, Thekla M.,Van Nispen, Reinier,Lugtenburg, Johan
-
p. 2909 - 2914
(2007/10/03)
-
- Inhibitors of sorotonin N-acetyltransferase
-
This invention is directed to a compound having the formula I. STR1 This invention is directed to a pharmaceutical composition comprising a compound which inhibits serotonin N-acetyltransferase having the formula I and a pharmaceutical acceptable carrier. The present invention relates to novel compounds and analogs which inhibit the serotonin N-acetyltransferase enzyme, and to processes for their preparation.
- -
-
-
- Process for preparing amides by reaction in presence of molecular sieve
-
There is provided a process for preparing amides which comprises reacting an amine, or an amide, and an acid halide, or anhydride, in suitable molecular proportions, in an inert organic diluent, in the presence of an effective amount of a molecular sieve, until the reaction is completed, separating the molecular sieve, and recovering the amide from the organic mother liquor.
- -
-
-
