Welcome to LookChem.com Sign In|Join Free

CAS

  • or

15088-78-5

Phenylacetyl disulfide (PADS) is a sulfurization reagent used in the preparation of phosphates, specifically in the synthesis of phosphorothioate oligodeoxyribonucleotides and RNA oligonucleotides. It can be synthesized by the reaction of phenyl benzenethiolsulfonate with thioacetic acid in the presence of triethylamine.

15088-78-5 Suppliers

Post Buying Request

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier
  • 15088-78-5 Structure

  • Basic information

    1. Product Name: Phenylacetyl disulfide
    2. Synonyms: PHENYLACETYL DISULFIDE;PHENYLACETYL DISULPHIDE;PADS;BIS(PHENYLACETYL) DISULFIDE;BIS(PHENYLACETYL) DISULPHIDE;DIPHENYLACETYL DISULFIDE;PADS (PHENYLACETYL DISULFIDE);PHENYLACETYL DISULFIDE (PADS)
    3. CAS NO:15088-78-5
    4. Molecular Formula: C16H14O2S2
    5. Molecular Weight: 302.41
    6. EINECS: N/A
    7. Product Categories: API intermediates;Naphthyridine,Quinoline;Organic Building Blocks;Sulfides/Disulfides;Sulfur Compounds
    8. Mol File: 15088-78-5.mol

  • Chemical Properties

    1. Melting Point: 59-63 °C(lit.)
    2. Boiling Point: 481.1 °C at 760 mmHg
    3. Flash Point: 210.1 °C
    4. Appearance: White crystal line powder
    5. Density: 1.269 g/cm3
    6. Vapor Pressure: 2.05E-09mmHg at 25°C
    7. Refractive Index: 1.638
    8. Storage Temp.: Inert atmosphere,Room Temperature
    9. Solubility: N/A
    10. Water Solubility: Insoluble in water.
    11. BRN: 2057579
    12. CAS DataBase Reference: Phenylacetyl disulfide(CAS DataBase Reference)
    13. NIST Chemistry Reference: Phenylacetyl disulfide(15088-78-5)
    14. EPA Substance Registry System: Phenylacetyl disulfide(15088-78-5)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: 22-24/25
    4. WGK Germany: 2
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 15088-78-5(Hazardous Substances Data)

15088-78-5 Usage

Uses

Used in Pharmaceutical Industry:
Phenylacetyl disulfide is used as a sulfur substitution agent for the synthesis of phosphorothioate oligodeoxyribonucleotides. This application is crucial in the development of modified nucleic acids with enhanced stability and resistance to degradation, which can be used in various therapeutic applications, such as gene therapy and antisense technology.
Used in Biochemical Research:
Phenylacetyl disulfide is used as a sulfur transfer agent during the preparation of RNA oligonucleotides. This application is essential in the study of RNA structure, function, and interactions with other biomolecules, contributing to the understanding of RNA biology and its role in various cellular processes.

Check Digit Verification of cas no

The CAS Registry Mumber 15088-78-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,5,0,8 and 8 respectively; the second part has 2 digits, 7 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 15088-78:
(7*1)+(6*5)+(5*0)+(4*8)+(3*8)+(2*7)+(1*8)=115
115 % 10 = 5
So 15088-78-5 is a valid CAS Registry Number.
InChI:InChI=1/C16H14O2S2/c17-15(11-13-7-3-1-4-8-13)19-20-16(18)12-14-9-5-2-6-10-14/h1-10H,11-12H2

15088-78-5 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail

  • TCI America

  • (B3623)  Bis(phenylacetyl) Disulfide  >98.0%(HPLC)

  • 15088-78-5

  • 5g

  • 580.00CNY

  • Detail

  • TCI America

  • (B3623)  Bis(phenylacetyl) Disulfide  >98.0%(HPLC)

  • 15088-78-5

  • 25g

  • 1,890.00CNY

  • Detail

  • Alfa Aesar

  • (L19792)  Bis(phenylacetyl) disulfide, 98%   

  • 15088-78-5

  • 5g

  • 334.0CNY

  • Detail

  • Alfa Aesar

  • (L19792)  Bis(phenylacetyl) disulfide, 98%   

  • 15088-78-5

  • 25g

  • 1076.0CNY

  • Detail

  • Aldrich

  • (554324)  Phenylacetyldisulfide  96%

  • 15088-78-5

  • 554324-25G

  • 974.61CNY

  • Detail

15088-78-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name Phenylacetyl disulfide

1.2 Other means of identification

Product number -
Other names Bis-phenylacetyl-disulfan

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:15088-78-5 SDS

15088-78-5Relevant articles and documents

Synthesis of antisense oligonucleotides: Replacement of 3H-1,2-benzodithiol-3-one 1,1-dioxide (Beaucage reagent) with phenylacetyl disulfide (PADS) as efficient sulfurization reagent: From bench to bulk manufacture of active pharmaceutical ingredient

Cheruvallath, Zacharia S.,Carty, Recaldo L.,Moore, Max N.,Capaldi, Daniel C.,Krotz, Achim H.,Wheeler, Patrick D.,Turney, Brett J.,Craig, Stephen R.,Gaus, Hans J.,Scozzari, Anthony N.,Cole, Douglas L.,Ravikumar, Vasulinga T.

, p. 199 - 204 (2000)

It is demonstrated that phosphorothioate oligodeoxyribonucleotides can be synthesized on scales from 1 μmol to 150 mmol using phenylacetyl disulfide (PADS) as an efficient and economical replacement for Beaucage reagent. A 0.2 M solution of PADS in a mixt

Diacyl disulfides as the precursors for hydrogen persulfide (H2S2)

Parent, Zoel,Wang, Yingying,Xian, Ming,Xu, Shi

, (2020)

While hydrogen polysulfides (H2Sn, n ≥ 2) are believed to play regulatory roles in biology, their fundamental chemistry and reactivity are still poorly understood. Compounds that can produce H2Sn are useful tool

Diacyl Disulfide: A Reagent for Chemoselective Acylation of Phenols Enabled by 4-(N,N-Dimethylamino)pyridine Catalysis

Liu, Hong-Xin,Dang, Ya-Qian,Yuan, Yun-Fei,Xu, Zhi-Fang,Qiu, Sheng-Xiang,Tan, Hai-Bo

supporting information, p. 5584 - 5587 (2016/11/17)

A general and excellent acylation reagent, diacyl disulfide, was uncovered for efficient ester formation enabled by DMAP (4-(N,N-dimethylamino)pyridine) catalysis. This protocol offered a promising synthetic platform on site-selective acylation of phenolic and primary aliphatic hydroxyl groups, which greatly expanded the realm of protecting group chemistry. The importance of the reagent was also reflected by its excellent moisture tolerance, high efficiency, and potential in synthetic chemistry and biologically meaningful natural product modification.

A facile method for the synthesis of diacyl disulfides

Jia, Xue-Shun,Liu, Xiao-Tao,Li, Qing,Huang, Qing,Kong, Ling-Long

, p. 547 - 548 (2007/10/03)

A facile method for the synthesis of diacyl disulfides is reported. Sulfur is reduced with samarium diiodide at room temperature to give samarium disulfides, which react with acyl chlorides in the presence of HMPA to afford the corresponding diacyl disulfides in high yields.

Synthesis of diacyl disulfides using a polymer supported reagent

Tamami,Kiasat

, p. 1275 - 1280 (2007/10/03)

Various diacyl disulfides are prepared easily in high yields from the corresponding acid chlorides under mild and non-aqueous conditions using a polymer supported reagent obtained from elemental sulfur and Amberlyst (OH)- . The polymeric reagent is regenerable.

A study on the use of phenylacetyl disulfide in the solid-phase synthesis of oligodeoxynucleoside phosphorothioates

Roelen, H. C. P. F.,Kamer, P. C. J.,Elst, H. van den,Marel, G. A. van der,Boom, J. H. van

, p. 325 - 331 (2007/10/02)

Sulfurization of protected internucleosidic phosphite triesters can be conveniently executed with the easily accessible reagent, phenylacetyl disulfide (1).High-quality oligodeoxynucleotides containi

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 15088-78-5