62167-00-4Relevant articles and documents
Radical-Mediated Acyl Thiol-Ene Reaction for Rapid Synthesis of Biomolecular Thioester Derivatives
Lynch, Dylan M.,McLean, Joshua T.,McSweeney, Lauren,Milbeo, Pierre,Scanlan, Eoin M.
supporting information, p. 4148 - 4160 (2021/08/24)
The thiol-ene ‘click’ reaction has emerged as a versatile process for carbon–sulfur bond formation with widespread applications in chemical biology, medicinal chemistry and materials science. Thioesters are key intermediates in a wide range of synthetic and biological processes and efficient methods for their synthesis are of considerable interest. Herein, we report the first examples of acyl-thiol-ene (ATE) for the synthesis of biomolecular thioesters, including peptide, lipid and carbohydrate derivatives. A key finding is the profound effect of the amino acid side chain on the outcome of the ATE reaction. Furthermore, radical generated thioesters underwent efficient S-to-N acyl transfer and desulfurisation to furnish ‘sulfur-free’ ligation products in an overall amidation process with diverse applications for chemical ligation and bioconjugation.
An easy and efficient method for the production of carboxylic acids and aldehydes by microbial oxidation of primary alcohols
Gandolfi, Raffaella,Ferrara, Nicola,Molinari, Francesco
, p. 513 - 514 (2007/10/03)
An easy and efficient methodology for obtaining aldehydes or carboxylic acids by oxidation of the corresponding primary alcohols with acetic acid bacteria is reported. When the biotransformation is performed in water the acids are obtained; aldehydes can be accumulated by using a water/isooctane two-liquid phase system.
Method of preparing a thiophene-containing or furan-containing conjugated compound and precursor compound used therein
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, (2008/06/13)
The invention relates to a method of preparing thiophene-containing or furan-containing conjugated compounds such as polythiophene. The method uses a precursor compound having tetrahydrothiophene or tetrahydrofuran precursor units having arylthio or alkylthio substituents. The precursor units can be thermally converted into thiophene or furan units. Due to the presence of the precursor units the precursor compound is soluble and can, unlike the corresponding conjugated compound, be processed from solution.