151229-84-4

Basic information

• Product Name: 2,6-dichloropyridine-3,5-dicarbonitrile
• Synonyms: 2,6-dichloropyridine-3,5-dicarbonitrile
• CAS NO: 151229-84-4
• Molecular Formula: C₇HCl₂N₃
• Molecular Weight: 198.00894
• Mol File: 151229-84-4.mol

Chemical Properties

• Boiling Point: 321.7±37.0 °C(Predicted)
• Appearance: /
• Density: 1.58±0.1 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -9.04±0.10(Predicted)
• CAS DataBase Reference: 2,6-dichloropyridine-3,5-dicarbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-dichloropyridine-3,5-dicarbonitrile(151229-84-4)
• EPA Substance Registry System: 2,6-dichloropyridine-3,5-dicarbonitrile(151229-84-4)

Safety Data

• Hazardous Substances Data: 151229-84-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2,6-dichloropyridine-3,5-dicarbonitrile is utilized as a key building block in the synthesis of various pharmaceuticals. Its unique structure allows for the development of new drugs with potential therapeutic applications, making it an essential component in medicinal chemistry.
Used in Agrochemical Industry:
In the agrochemical sector, 2,6-dichloropyridine-3,5-dicarbonitrile serves as a crucial intermediate for the production of pesticides and other agrochemicals. Its reactivity enables the creation of compounds with effective pest control properties, contributing to agricultural productivity and crop protection.
Used in Fine Chemicals Production:
2,6-dichloropyridine-3,5-dicarbonitrile is employed as a versatile intermediate in the synthesis of a wide range of fine chemicals. Its ability to participate in various chemical reactions facilitates the production of specialty chemicals used in industries such as fragrances, dyes, and coatings.
Used in Chemical Research:
As a starting material, 2,6-dichloropyridine-3,5-dicarbonitrile is instrumental in the development of new materials and catalysts in the field of chemical research. Its reactivity and functional groups make it a valuable component in exploring novel chemical reactions and advancing scientific knowledge.

Upstream product

• 32019-26-4 H-TCNP 
• 51768-01-5 2-amino-6-chloropyridine-3,5-dicarbonitrile 

Downstream Products

• 1335032-54-6 2-((1-benzylpiperidin-4-yl)amino)-6-chloropyridine-3,5-dicarbonitrile 
• 1335032-57-9 2,6-bis((1-benzylpiperidin-4-yl)amino)pyridine-3,5-dicarbonitrile 
• 1335032-55-7 2-((2-(1-benzylpiperidin-4-yl)ethyl)amino)-6-chloropyridine-3,5-dicarbonitrile 
• 1456626-39-3 2-((4-(1-benzylpiperidin-4-yl)butyl)amino)-6-chloropyridine-3,5-dicarbonitrile 
• 1456626-38-2 2-((3-(1-benzylpiperidin-4-yl)propyl)amino)-6-chloropyridine-3,5-dicarbonitrile 
• 1335032-37-5 2-((2-(1-benzylpiperidin-4-yl)ethyl)amino)-6-(prop-2-yn-1-ylamino)pyridine-3,5-dicarbonitrile 
• 1335032-36-4 2-((1-benzylpiperidin-4-yl)amino)-6-(prop-2-yn-1-ylamino)pyridine-3,5-dicarbonitrile 
• 1335032-34-2 2-((2-(1-benzylpiperidin-4-yl)ethyl)amino)-6-(methyl(prop-2-yn-1-yl)amino)pyridine-3,5-dicarbonitrile 
• 654664-92-3 diethyl 3,5-bis[4-chloroanilino(piperidino)methyleneamino]dithieno[3',2'-e:2,3-b]pyridine-2,6-dicarboxylate 
• 654664-91-2 diethyl 3,5-bis[4-methoxyanilino(morpholino)methyleneamino]dithieno[3',2'-e:2,3-b]pyridine-2,6-dicarboxylate 
• 654664-88-7 diethyl 3,5-bis[anilino(thiomorpholino)methyleneamino]dithieno[3',2'-e:2,3-b]pyridine-2,6-dicarboxylate 
• 654664-90-1 diethyl 3,5-bis[anilino(morpholino)methyleneamino]dithieno[3',2'-e:2,3-b]pyridine-2,6-dicarboxylate 
• 654664-81-0 diethyl 3,5-di[(triphenylphosphoranylidene)amino]dithieno[3',2'-e:2,3-b]pyridine-2,6-dicarboxylate 

Relevant articles and documents

Discovery of Novel Pyrido-pyridazinone Derivatives as FER Tyrosine Kinase Inhibitors with Antitumor Activity

To obtain a new anticancer drug, we focused on FER tyrosine kinase. Starting with high-throughput screening with our in-house chemical library, compound 1, which has a pyridine moiety, was found. Referring to their X-ray crystal structure with FES proto-oncogene tyrosine kinase, as a surrogate of FER followed by chemical modification including scaffold hopping of the pyridine template, we discovered pyrido-pyridazinone derivatives with potent FER kinase inhibitory activity. Here, we disclose the structure-activity relationship on the scaffold and representative compound 21 (DS21360717), which showed in vivo antitumor efficacy in a subcutaneous tumor model.

Synthesis of pyrido and pyrazinodithienodipyrimidine-4,8(3H,9H)-dione derivatives by the aza-Wittig methodology

A one-pot synthesis of the hitherto unreported pyrido[5″,6″:4, 5;3″2″:4′,5′]dithieno[3,2-d:3′,2′-d′] dipyrimidine-4,8(3H,9H)-dione 6a-o and pyrazino[5″,6″:4, 5;3″2″:4′,5′]dithieno[3,2-d:3′,2′-d′] dipyrimidine-4,8(3H,9H)-dione 6p-y pentaheterocyclic systems, based on the tandem aza-Wittig heterocumulene-mediated annulation strategy is described.

One pot synthesis of 2,6-dichloro-3,5-dicyanopyridine from aliphatic precursors

Malononitrile is condensed with triethyl orthoformate in the presence of pyridine; the mixture is acidified with HCl gas and after addition of further pyridine, HCl diazotised to form 2,6-dichloro-3,5-dicyanopyridine in a convenient, high yield process.