51768-01-5

Basic information

• Product Name: 2-AMINO-6-CHLORO-3,5-DICYANOPYRIDINE
• Synonyms: 2-AMINO-6-CHLORO-3,5-DICYANOPYRIDINE;2-Amino-6-chloro-3,5-dicyanopyridine ,97%;2-aMino-6-chloropyridine-3,5-dicarbonitrile
• CAS NO: 51768-01-5
• Molecular Formula: C₇H₃ClN₄
• Molecular Weight: 178.58
• Product Categories: pharmacetical
• Mol File: 51768-01-5.mol
• Article Data: 10

Chemical Properties

• Melting Point: 280 °C
• Boiling Point: 372.6 °C at 760 mmHg
• Flash Point: 179.1 °C
• Appearance: /
• Density: 1.51 g/cm³
• Vapor Pressure: 9.53E-06mmHg at 25°C
• Refractive Index: 1.635
• Storage Temp.: 2-8°C
• PKA: -3.75±0.10(Predicted)
• CAS DataBase Reference: 2-AMINO-6-CHLORO-3,5-DICYANOPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-6-CHLORO-3,5-DICYANOPYRIDINE(51768-01-5)
• EPA Substance Registry System: 2-AMINO-6-CHLORO-3,5-DICYANOPYRIDINE(51768-01-5)

Safety Data

• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 51768-01-5(Hazardous Substances Data)

Usage

Chemical Properties

Gray solid

Synthesis Reference(s)

Journal of Medicinal Chemistry, 44, p. 2391, 2001 DOI: 10.1021/jm010856uJournal of the American Chemical Society, 80, p. 2832, 1958 DOI: 10.1021/ja01544a060

InChI:InChI=1/C7H3ClN4/c8-6-4(2-9)1-5(3-10)7(11)12-6/h1H,(H2,11,12)

Upstream product

• 13572-75-3 1,1,3,3-tetracyanopropene pyridine salt 
• 1188-33-6 N,N-dimethylformamide diethyl diacetal 
• 109-77-3 malononitrile 
• 122-51-0 orthoformic acid triethyl ester 
• 51767-89-6 4-chloro-7-methyl-5,7-diaza-1,3,5-octatriene-1,1,3-tricarbonitrile 
• 32019-26-4 H-TCNP 

Downstream Products

• 172208-08-1 2-chloro-3,5-dicyanopyridine 
• 1415570-65-8 C₂₃H₂₈N₆ 
• 1415570-64-7 C₂₂H₂₆N₆ 
• 1415570-62-5 C₂₁H₂₄N₆ 
• 1415570-61-4 C₁₉H₂₀N₆ 
• 1335032-40-0 7-(2-(1-benzylpiperidin-4-yl)ethyl)-2-(methyl(prop-2-yn-1-yl)amino)-1,8-naphthyridine-3-carbonitrile 

Relevant articles and documents

Synthesis of 2,4-Diamino-6-(thioarylmethyl)pyrido[2,3-d]pyrimidines as dihydrofolate reductase inhibitors

Six 2,4-diaminopyrido[2,3-d]pyrimidines with a 6-merhylthio bridge to an aryl group were synthesize and biologically evaluate as inhibitors of Pneumocystis carinii (pc) and Toxoplasma gondii (tg) dihydrofolate reductase (DHFR). The syntheses of analogues

Medicine comprising dicyanopyridine derivative

Compounds having a high conductance-type of calcium-activated K channel opening effect and a smooth muscle relaxant effect for bladder based on the K-channel opening effect, which can be used in treating pollakiuria and urinary incontinence, are provided.

Design, synthesis, computational prediction, and biological evaluation of ester soft drugs as inhibitors of dihydrofolate reductase from pneumocystis carinii

A series of lipophilic soft drugs structurally related to the nonclassical dihydrofolate reductase (DHFR) inhibitors trimetrexate and piritrexim have been designed, synthesized, and evaluated in DHFR assays, with special emphasis on the inhibition of P. c