151265-36-0

Basic information

• Product Name: (16α)-21-Chloro-17-hydroxy-16-Methylpregna-1,4,9(11)-triene-3,20-dione
• Synonyms: (16α)-21-Chloro-17-hydroxy-16-Methylpregna-1,4,9(11)-triene-3,20-dione
• CAS NO: 151265-36-0
• Molecular Formula: C22H27ClO3
• Molecular Weight: 374.9
• Product Categories: Pharmaceuticals, Intermediates & Fine Chemicals, Steroids
• Mol File: 151265-36-0.mol

Chemical Properties

• Boiling Point: 535.1±50.0 °C(Predicted)
• Appearance: /
• Density: 1.24±0.1 g/cm3(Predicted)
• PKA: 12.43±0.70(Predicted)
• CAS DataBase Reference: (16α)-21-Chloro-17-hydroxy-16-Methylpregna-1,4,9(11)-triene-3,20-dione(CAS DataBase Reference)
• NIST Chemistry Reference: (16α)-21-Chloro-17-hydroxy-16-Methylpregna-1,4,9(11)-triene-3,20-dione(151265-36-0)
• EPA Substance Registry System: (16α)-21-Chloro-17-hydroxy-16-Methylpregna-1,4,9(11)-triene-3,20-dione(151265-36-0)

Safety Data

• Hazardous Substances Data: 151265-36-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
(16α)-21-Chloro-17-hydroxy-16-Methylpregna-1,4,9(11)-triene-3,20-dione is used as an intermediate in the synthesis of Mometasone Furoate (M490000), a topical corticosteroid. It serves as a key component in the production process, enabling the creation of an anti-inflammatory agent that can be applied to treat various skin conditions, such as eczema, dermatitis, and other inflammatory skin disorders.
Application Reason:
The compound's unique structure allows it to be a vital building block in the synthesis of Mometasone Furoate, which is known for its potent anti-inflammatory properties. By acting as an intermediate, (16α)-21-Chloro-17-hydroxy-16-Methylpregna-1,4,9(11)-triene-3,20-dione contributes to the development of an effective treatment for skin inflammation and other related conditions.

Upstream product

• 13209-41-1 (8S,10S,13S,14S,16R,17R)-17-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-7,8,12,14,15,16-hexahydro-6H-cyclopenta[a]phenanthren-3-one 
• 898-84-0 11α-hydroxy-androsta-1,4-diene-3,17-dione 
• 124-63-0 methanesulfonyl chloride 

Relevant articles and documents

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