124-63-0 Usage
Chemical Description
Different sources of media describe the Chemical Description of 124-63-0 differently. You can refer to the following data:
1. Methanesulfonyl chloride is a colorless or pale yellow liquid with a pungent odor.
2. Methanesulfonyl chloride is used to convert pure alcohols into their corresponding azido mesylates.
3. Methanesulfonyl chloride was used to give the sulfonamides 5, 6, 7, and 8.
4. Methanesulfonyl chloride is a reagent used to prepare 5-[bis(2-chloroethyl)amino]-indoles, while benzo[b]thiophene is a compound investigated for its ability to antagonize the actions of 5-HT.
5. Methanesulfonyl chloride and pyridine are used to protect the hydroxyl group in the acetonide 13.
6. Methanesulfonyl chloride is a source of the methanesulfonyl group (CH3SO2-), which is a common protecting group for alcohols, amines, and other functional groups in organic chemistry.
7. Methanesulfonyl chloride and triethylamine are reagents used in the synthesis of cyanomesyl derivatives.
8. Methanesulfonyl chloride is an organic compound with the chemical formula CH3SO2Cl.
Chemical Properties
Different sources of media describe the Chemical Properties of 124-63-0 differently. You can refer to the following data:
1. Colorless to yellow liquid
2. Pale yellow corrosive liquid. Unpleasant, pungent odor.
Uses
Different sources of media describe the Uses of 124-63-0 differently. You can refer to the following data:
1. In the synthesis of photographic and agricultural chemicals, pharmaceutical intermediates. As a stabilizer; catalyst; curing and chlorinating agent; precursor to methanesulfonic acid.
2. Methanesulfonyl chloride is used as a reagent for conversion of alcohols to mesylate esters such as methanesulfonate, which is an intermediate in substitution reactions, elimination reactions, reductions, and rearrangement reactions viz. Beckmann rearrangement. It is an electrophile and acts as a source of CH3SO2+ group. It is also used to prepare beta-chloro sulfones, methanesulfonamide and heterocyclic compounds containing five membered sultones.
3. Methanesulfonyl chloride can be used for the mesylation of primary alcohols to synthesize the corresponding methanesulfonates. It may also be used for the conversion of amines to the corresponding sulfonamides.
General Description
A pale yellow corrosive liquid. More dense than water and insoluble in water. Very toxic by ingestion, inhalation, or skin absorption.
Reactivity Profile
Methanesulfonyl chloride reacts vigorously with water, steam, alkali, methylformamide. Emits toxic fumes of chloride and oxides of sulfur when heated to decomposition. A dangerous storage hazard. Reacts explosively with dimethyl sulfoxide [Buckley, A., J. Chem. Educ., 1965, 42, p. 674]. May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291].
Health Hazard
TOXIC; inhalation, ingestion or contact (skin, eyes) with vapors, dusts or substance may cause severe injury, burns or death. Contact with molten substance may cause severe burns to skin and eyes. Reaction with water or moist air will release toxic, corrosive or flammable gases. Reaction with water may generate much heat that will increase the concentration of fumes in the air. Fire will produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.
Fire Hazard
Combustible material: may burn but does not ignite readily. Substance will react with water (some violently) releasing flammable, toxic or corrosive gases and runoff. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapors may travel to source of ignition and flash back. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated or if contaminated with water.
Potential Exposure
Chemical intermediate in various
industries including pesticides, flame retardants, pharmaceuticals, plastics. A solvent, curing agent, and chemical
stabilizer. Laboratory chemical.
Shipping
UN3246 Methanesulfonyl chloride, Hazard Class
6.1; Labels: 6.1-Poison Inhalation Hazard, 8-Corrosive
material, Inhalation Hazard Zone B.
Purification Methods
Distil the sulfonyl chloride from P2O5 under vacuum. It is a strong IRRITANT.[Beilstein 4 IV 27.]
Incompatibilities
Vapors may form explosive mixture with
air. Slowly reacts with water, releasing toxic and corrosive
hydrogen chloride gas. Incompatible with oxidizers
(chlorates, nitrates, peroxides, permanganates, perchlorates,
chlorine, bromine, fluorine, etc.); contact may cause fires
or explosions. Keep away from alkaline materials, DMSO,
ethers, strong acids, strong bases.
Waste Disposal
Use a licensed professional
waste disposal service to dispose of this material. Dissolve
or mix the material with a combustible solvent and burn
in a chemical incinerator equipped with an afterburner
and scrubber. All federal, state, and local environmental
regulations must be observed
Check Digit Verification of cas no
The CAS Registry Mumber 124-63-0 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,2 and 4 respectively; the second part has 2 digits, 6 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 124-63:
(5*1)+(4*2)+(3*4)+(2*6)+(1*3)=40
40 % 10 = 0
So 124-63-0 is a valid CAS Registry Number.
InChI:InChI=1/CH3ClO2S/c1-5(2,3)4/h1H3
124-63-0Relevant articles and documents
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Proell,Adams,Shoemaker
, p. 1129 (1948)
-
-
Douglass,Norton
, p. 2104 (1968)
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Experimental study on deep desulfurization of MTBE by electrochemical oxidation and distillation
Li, Jing-Jing,Zhou, Fei,Tang, Xiao-Dong,Hu, Tao,Cheng, Jin
, p. 4803 - 4809 (2016)
With the increasing awareness of environmental protection, deep desulfurization of methyl tert-butyl ether (MTBE), which is the most important octane booster in gasoline, is extremely urgent. Herein, a new desulfurization method, involving the combination of electrochemical oxidation and distillation, is proposed to reduce the sulfur content in MTBE. Under optimum operating conditions, the sulfur content of real MTBE decreases from 132.5 μg g-1 to 2.3 μg g-1 and the desulfurization efficiency reaches 98.25%. The oxidation products with high boiling points can be separated by distillation. FTIR analyses prove that electrochemical oxidation has no influence on the main properties of MTBE. Moreover, GC/MS is used to study the conversion of model organic sulfides (dimethyl disulfide, diethyl sulfide and butyl mercaptan) in the electrochemical oxidative desulfurization process. Finally, the possible reaction mechanism of the electrochemical oxidative desulfurization of MTBE is proposed.
-
Norton et al.
, p. 3645 (1967)
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A practical and efficient method for the preparation of sulfonamides utilizing Cl3CCN/PPh3
Chantarasriwong, Oraphin,Jang, Doo Ok,Chavasiri, Warinthorn
, p. 7489 - 7492 (2006)
Cl3CCN in combination with PPh3 proved to be a highly reactive reagent for the conversion of sulfonic acids to the corresponding sulfonyl chlorides in refluxing CH2Cl2. Upon reaction with amines, the corresponding sulfonamides were obtained in good to excellent yields.
-
Noller,Hearst
, p. 3955 (1948)
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FTIR Kinetic and Mechanistic Study of the Atmospheric Chemistry of Methyl Thiolformate
Patroescu, Iulia V.,Barnes, Ian,Becker, Karl H.
, p. 17207 - 17217 (1996)
Some aspects of the atmospheric chemistry of methyl thiolformate (CH3SCHO), a recently detected intermediate in the oxidation of dimethyl sulfide, have been investigated at 298 K and 1000 mbar total pressure in large reaction chambers using long path in situ FTIR absorption spectroscopy for the analysis.Rate coefficients of (1.11 +/- 0.22)E-11 and (5.80 +/- 0.80)E-11 cm3 molecule-1 s-1 have been determined for its reaction with OH radicals and Cl atoms, respectively.The UV spectrum of CH3SCHO has been measured in the range 220-355 nm and a lower limit of 5.4 days determined for its atmospheric photolytic lifetime.Detailed product analyses have made for the OH and Cl initiated photooxidation of CH3SCHO.Strong SO absorption bands observed in both systems are tentatively assigned to CH3SOCHO in the OH system and to CH3SOCl in the Cl system.The first gas-phase spectra of CH3SCl and CH3SOCl are also presented.The results are discussed with respect to the atmospheric chemistry of CH3SCHO and possible consequences for the photooxidation mechanism of dimethyl sulfide.
Selective Late-Stage Sulfonyl Chloride Formation from Sulfonamides Enabled by Pyry-BF4
Gómez-Palomino, Alejandro,Cornella, Josep
supporting information, p. 18235 - 18239 (2019/11/13)
Reported here is a simple and practical functionalization of primary sulfonamides, by means of a pyrylium salt (Pyry-BF4), with nucleophiles. This simple reagent activates the poorly nucleophilic NH2 group in a sulfonamide, enabling the formation of one of the best electrophiles in organic synthesis: a sulfonyl chloride. Because of the variety of primary sulfonamides in pharmaceutical contexts, special attention has been focused on the direct conversion of densely functionalized primary sulfonamides by a late-stage formation of the corresponding sulfonyl chloride. A variety of nucleophiles could be engaged in this transformation, thus permitting the synthesis of complex sulfonamides, sulfonates, sulfides, sulfonyl fluorides, and sulfonic acids. The mild reaction conditions and the high selectivity of Pyry-BF4 towards NH2 groups permit the formation of sulfonyl chlorides in a late-stage fashion, tolerating a preponderance of sensitive functionalities.
BIODEGRADABLE POLYETHYLENE GLYCOL DERIVATIVE HAVING CYCLIC BENZYLIDENE ACETAL LINKER
-
, (2018/04/14)
A biodegradable polyethylene glycol derivative in which a polyethylene glycol chain is linked by an acetal linker capable of accurately controlling the hydrolysis rate under different pH environments in the living body, and whose division rate into a polyethylene glycol chain of low molecular weight in the living body can be accurately controlled. The biodegradable polyethylene glycol derivative is represented by formula (1) or formula (2) as described.
This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.
