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124-63-0

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Product FOB Price Min.Order Supply Ability Supplier
Methanesulfonyl chloride
Cas No: 124-63-0
No Data 250 Kilogram / QINGDAO ON-BILLION INDUSTRAIL CO.,LTD Contact Supplier
Methylsulfonyl chloride
Cas No: 124-63-0
USD $ 500.0-500.0 / Gram 1 Gram 1000 Gram/Day Pure Chemistry Scientific Inc. Contact Supplier

124-63-0 Usage

Reactivity Profile

Methanesulfonyl chloride reacts vigorously with water, steam, alkali, methylformamide. Emits toxic fumes of chloride and oxides of sulfur when heated to decomposition. A dangerous storage hazard. Reacts explosively with dimethyl sulfoxide [Buckley, A., J. Chem. Educ., 1965, 42, p. 674]. May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291].

Chemical Properties

Colorless to yellow liquid

Purification Methods

Distil the sulfonyl chloride from P2O5 under vacuum. It is a strong IRRITANT.[Beilstein 4 IV 27.]

General Description

A pale yellow corrosive liquid. More dense than water and insoluble in water. Very toxic by ingestion, inhalation, or skin absorption.

Health Hazard

TOXIC; inhalation, ingestion or contact (skin, eyes) with vapors, dusts or substance may cause severe injury, burns or death. Contact with molten substance may cause severe burns to skin and eyes. Reaction with water or moist air will release toxic, corrosive or flammable gases. Reaction with water may generate much heat that will increase the concentration of fumes in the air. Fire will produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.

Fire Hazard

Combustible material: may burn but does not ignite readily. Substance will react with water (some violently) releasing flammable, toxic or corrosive gases and runoff. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapors may travel to source of ignition and flash back. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated or if contaminated with water.

Uses

In the synthesis of photographic and agricultural chemicals, pharmaceutical intermediates. As a stabilizer; catalyst; curing and chlorinating agent; precursor to methanesulfonic acid.
InChI:InChI=1/CH3ClO2S/c1-5(2,3)4/h1H3

124-63-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name Methanesulfonyl chloride

1.2 Other means of identification

Product number -
Other names Intermediates: Methanesulfonyl Chloride

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. Pigments
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:124-63-0 SDS

124-63-0Synthetic route

Dimethyldisulphide
624-92-0

Dimethyldisulphide

methanesulfonyl chloride
124-63-0

methanesulfonyl chloride

Conditions
ConditionsYield
With hydrogenchloride; manganese(IV) oxide; potassium sulfate; water at 60 - 90℃; for 22h; Reagent/catalyst; Temperature; Large scale;99.81%
With chloro-trimethyl-silane; potassium nitrate In dichloromethane at 50℃; for 8h;90%
S,S-dimethyl dithiocarbonate
868-84-8

S,S-dimethyl dithiocarbonate

methanesulfonyl chloride
124-63-0

methanesulfonyl chloride

Conditions
ConditionsYield
With water; chlorine at 5 - 10℃; for 0.25h;95%
Chloromethyltrimethylsilane
2344-80-1

Chloromethyltrimethylsilane

A

Chloro(chloromethyl)dimethylsilane
1719-57-9

Chloro(chloromethyl)dimethylsilane

B

sulfate de bis-(dimethylchloromethylsilyle)
20991-92-8

sulfate de bis-(dimethylchloromethylsilyle)

C

methanesulfonyl chloride
124-63-0

methanesulfonyl chloride

Conditions
ConditionsYield
With chlorosulfonic acid at 50 - 80℃;A n/a
B 92%
C n/a
[(methylthio)methyl]-benzene
766-92-7

[(methylthio)methyl]-benzene

methanesulfonyl chloride
124-63-0

methanesulfonyl chloride

Conditions
ConditionsYield
With hydrogenchloride; iodosylbenzene for 0.0833333h; Chlorination; oxidation;91%
With hydrogenchloride; iodosylbenzene for 0.0833333h;91 % Chromat.
N-chlorodimesylamine
71954-24-0

N-chlorodimesylamine

diphenyl phenylphosphonate
3049-24-9

diphenyl phenylphosphonate

A

N-Mesyl-triphenoxyphosphinimid
102173-66-0

N-Mesyl-triphenoxyphosphinimid

B

methanesulfonyl chloride
124-63-0

methanesulfonyl chloride

Conditions
ConditionsYield
In dichloromethane for 18h;A 82%
B n/a
S-Methylisothiourea sulfate
867-44-7

S-Methylisothiourea sulfate

methanesulfonyl chloride
124-63-0

methanesulfonyl chloride

Conditions
ConditionsYield
With tert-butylhypochlorite In water; acetonitrile at 0 - 20℃;79%
In diethyl ether; water at 0 - 20℃; for 0.5h; Green chemistry;0.808 g
methane
34557-54-5

methane

A

dichloromethane
75-09-2

dichloromethane

B

methanesulfonyl chloride
124-63-0

methanesulfonyl chloride

Conditions
ConditionsYield
With sulfur dioxide; chlorine at 25℃; under 2250.23 Torr; for 1h; Concentration; Wavelength; Irradiation;A n/a
B 69%
N-chlorodimesylamine
71954-24-0

N-chlorodimesylamine

A

N-Mesyl-trichlorphosphinimid
29651-24-9

N-Mesyl-trichlorphosphinimid

B

methanesulfonyl chloride
124-63-0

methanesulfonyl chloride

Conditions
ConditionsYield
With phosphorus trichloride In dichloromethane; chloroform for 12h;A 61%
B n/a
methane
34557-54-5

methane

A

tetrachloromethane
56-23-5

tetrachloromethane

B

methylene chloride
74-87-3

methylene chloride

C

dichloromethane
75-09-2

dichloromethane

D

chloroform
67-66-3

chloroform

E

methanesulfonyl chloride
124-63-0

methanesulfonyl chloride

Conditions
ConditionsYield
With hydrogenchloride; sulfur dioxide; chlorine at 63 - 67℃; under 6750.68 Torr; Photolysis;A n/a
B n/a
C n/a
D n/a
E 55%
methane
34557-54-5

methane

A

dichloromethane
75-09-2

dichloromethane

B

chloroform
67-66-3

chloroform

C

methanesulfonyl chloride
124-63-0

methanesulfonyl chloride

Conditions
ConditionsYield
With sulfur dioxide; chlorine at 65℃; under 2250.23 Torr; for 1h; Temperature; Irradiation;A n/a
B n/a
C 54.9%
(dichloromethyl)trimethylsilane
5926-38-5

(dichloromethyl)trimethylsilane

A

methanesulfonyl chloride
124-63-0

methanesulfonyl chloride

B

C3H7Cl3O3SSi
107716-52-9

C3H7Cl3O3SSi

C

C3H7Cl3O3SSi
107716-51-8

C3H7Cl3O3SSi

D

C6H14Cl4O4SSi2
107716-53-0

C6H14Cl4O4SSi2

Conditions
ConditionsYield
at 90 - 100℃; Further byproducts given;A n/a
B 51%
C n/a
D n/a
methanesulfonic acid
75-75-2

methanesulfonic acid

methanesulfonyl chloride
124-63-0

methanesulfonyl chloride

Conditions
ConditionsYield
With 1,3,5-trichloro-2,4,6-triazine; triethylamine In acetone for 20h; Heating;47%
With thionyl chloride at 95℃;
With phosphorus trichloride at 80℃;
methane
34557-54-5

methane

methanesulfonyl chloride
124-63-0

methanesulfonyl chloride

Conditions
ConditionsYield
With sulfur dioxide; chlorine at -10 - 110℃; for 2h; Product distribution / selectivity; Sealed reactor;47%
With sulfuryl dichloride; sulfur trioxide; dihydrogen peroxide; rhodium(III) chloride; urea In sulfuric acid at 60℃; under 36201.3 Torr; for 12h;1.9 mmol
methane
34557-54-5

methane

A

chloroform
67-66-3

chloroform

B

methanesulfonyl chloride
124-63-0

methanesulfonyl chloride

Conditions
ConditionsYield
With sulfur dioxide; chlorine at 25℃; under 2250.23 Torr; for 1h; Temperature; Irradiation;A n/a
B 43.3%
methylsulphinyl chloride
676-85-7

methylsulphinyl chloride

methanesulfonyl chloride
124-63-0

methanesulfonyl chloride

Conditions
ConditionsYield
With chlorine13.5%
methyl thiocyanate
556-64-9

methyl thiocyanate

methanesulfonyl chloride
124-63-0

methanesulfonyl chloride

Conditions
ConditionsYield
With water; chlorine
With water; chlorine
methyl magnesium iodide
917-64-6

methyl magnesium iodide

methanesulfonyl chloride
124-63-0

methanesulfonyl chloride

Conditions
ConditionsYield
With sulfuryl dichloride; diethyl ether at 10℃;
dimethylsulfide
75-18-3

dimethylsulfide

methanesulfonyl chloride
124-63-0

methanesulfonyl chloride

Conditions
ConditionsYield
With water; chlorine
Methanesulfenyl chloride
5813-48-9

Methanesulfenyl chloride

methanesulfonyl chloride
124-63-0

methanesulfonyl chloride

Conditions
ConditionsYield
With diethyl ether; nitric acid at -15℃;
2-methylisothiourea sulphate
14527-26-5, 867-44-7

2-methylisothiourea sulphate

methanesulfonyl chloride
124-63-0

methanesulfonyl chloride

Conditions
ConditionsYield
With water; chlorine at 10 - 15℃;
Methanesulfonic anhydride
7143-01-3

Methanesulfonic anhydride

methanesulfonyl chloride
124-63-0

methanesulfonyl chloride

Conditions
ConditionsYield
With hydrogenchloride at 105℃;
1-Heptene
592-76-7

1-Heptene

methanedisulfonyl chloride
5799-68-8

methanedisulfonyl chloride

A

1,3-dichlorooctane
5799-71-3

1,3-dichlorooctane

B

3-chloro-octanesulfonyl chloride
5799-72-4

3-chloro-octanesulfonyl chloride

C

methanesulfonyl chloride
124-63-0

methanesulfonyl chloride

Conditions
ConditionsYield
With dibenzoyl peroxide In benzene Heating;
α,α-Dichlor-dimethylsulfid
64258-22-6

α,α-Dichlor-dimethylsulfid

methanesulfonyl chloride
124-63-0

methanesulfonyl chloride

Conditions
ConditionsYield
With water; chlorine In acetic acid
methylsulphinyl chloride
676-85-7

methylsulphinyl chloride

A

methanethiosulfonic acid S-methyl ester
2949-92-0

methanethiosulfonic acid S-methyl ester

B

dimethylsulfide
75-18-3

dimethylsulfide

C

S-methyl methanethiosulfinate
13882-12-7

S-methyl methanethiosulfinate

D

methyl methanesulfinyl sulfone
14128-56-4

methyl methanesulfinyl sulfone

E

Zinc methanesulfinate
19186-23-3

Zinc methanesulfinate

F

methanesulfonyl chloride
124-63-0

methanesulfonyl chloride

Conditions
ConditionsYield
With zinc In various solvent(s) at -30℃; for 1.5h; Mechanism; Product distribution; var. solv., var. time, var. temp.;A 7 % Spectr.
B 1 % Spectr.
C 3 % Spectr.
D 1 % Spectr.
E 5 % Spectr.
F 9 % Spectr.
methylsulphinyl chloride
676-85-7

methylsulphinyl chloride

A

methanethiosulfonic acid S-methyl ester
2949-92-0

methanethiosulfonic acid S-methyl ester

B

dimethylsulfide
75-18-3

dimethylsulfide

C

S-(chloromethyl) methanesulphonothioate
22224-96-0

S-(chloromethyl) methanesulphonothioate

D

methanesulfonyl chloride
124-63-0

methanesulfonyl chloride

Conditions
ConditionsYield
triethylamine In diethyl ether at 22 - 24℃; for 24h; Product distribution; other amines;A 6 % Spectr.
B 5 % Spectr.
C 27 % Spectr.
D 3 % Spectr.
dimethyl sulfoxide
67-68-5

dimethyl sulfoxide

A

methanethiosulfonic acid S-methyl ester
2949-92-0

methanethiosulfonic acid S-methyl ester

B

dimethylsulfone
67-71-0

dimethylsulfone

C

hydrochloric acid, dimethyl sulphoxide
26394-12-7

hydrochloric acid, dimethyl sulphoxide

D

methanesulfonyl chloride
124-63-0

methanesulfonyl chloride

Conditions
ConditionsYield
With chlorine In dichloromethane at -0.1℃;
With chlorine In dichloromethane at -0.1℃; Further byproducts given;
Tetrahydro-pyran-4-ol
2081-44-9

Tetrahydro-pyran-4-ol

methanesulfonyl chloride
124-63-0

methanesulfonyl chloride

4-oxanyl methanesulfonate
134419-59-3

4-oxanyl methanesulfonate

Conditions
ConditionsYield
With triethylamine In dichloromethane at 0 - 20℃; for 2.5h;100%
With triethylamine In dichloromethane at 0 - 20℃; for 2.5h;100%
With triethylamine In dichloromethane at 0℃; for 1.5h;100%
methanol
67-56-1

methanol

methanesulfonyl chloride
124-63-0

methanesulfonyl chloride

Methyl methanesulfonate
66-27-3

Methyl methanesulfonate

Conditions
ConditionsYield
Stage #1: methanol With triethylamine In dichloromethane at 25℃;
Stage #2: methanesulfonyl chloride In dichloromethane at 0 - 20℃;
100%
With pyridine; diethyl ether at -30℃;
With triethylamine
propan-1-ol
71-23-8

propan-1-ol

methanesulfonyl chloride
124-63-0

methanesulfonyl chloride

propyl methanesulfonate
1912-31-8

propyl methanesulfonate

Conditions
ConditionsYield
With triethylamine In dichloromethane at 0 - 20℃; for 1h;100%
With pyridine 1.) from -20 deg C to 30 deg C, 2.) room temp., 2 h;65%
With pyridine at 0℃;
4-nitro-phenol
100-02-7

4-nitro-phenol

methanesulfonyl chloride
124-63-0

methanesulfonyl chloride

p-nitrophenyl methanesulfonate
20455-07-6

p-nitrophenyl methanesulfonate

Conditions
ConditionsYield
With triethylamine In dichloromethane at 0 - 20℃; for 0.75h;100%
With triethylamine In dichloromethane at 0 - 20℃;98%
With triethylamine In ethyl acetate at 0 - 20℃; for 0.166667h; Green chemistry;97%
n-Pent-4-enyl alcohol
821-09-0

n-Pent-4-enyl alcohol

methanesulfonyl chloride
124-63-0

methanesulfonyl chloride

4-pentenyl mesylate
64818-35-5

4-pentenyl mesylate

Conditions
ConditionsYield
With triethylamine In dichloromethane at -15℃; for 1h; Green chemistry;100%
With triethylamine In dichloromethane at -5℃; for 0.666667h;98%
With triethylamine In dichloromethane at 0 - 20℃; for 91312.5h; Inert atmosphere;98%

124-63-0Related news

Cytogenetic effects of softwood kraft pulp bleaching effluents and Methanesulfonyl chloride (cas 124-63-0) in Chinese hamster ovary cells09/27/2019

The genotoxicity of effluents collected from a conventional 5-stage softwood kraft pulp bleaching process was studied in Chinese hamster ovary (CHO) cells in vitro. Spent liquor from the first chlorination stage (C/D), where elemental chlorine and chlorine dioxide had been used in equal proporti...detailed

An efficient β-amino acid cyclodehydration using Methanesulfonyl chloride (cas 124-63-0) to thienamycin intermediate 3-[1-hydroxyethyl]-4-[methoxy carbonylmethyl]-azetidin-2-one09/26/2019

A new process for β-amino acid 1 cyclodehydration to β-lactam 2 using methanesulfonyl chloride/ sodium bicarbonate is described.detailed

Facile preparation of chloromethylaryl solid supports using Methanesulfonyl chloride (cas 124-63-0) and Hunig's base09/25/2019

Several commercially available hydroxymethylaryl resins were converted to their corresponding chloromethyl analogs by simple treatment with methanesulfonyl chloride and Hunig's base in DMF at 25 °C over 3 days. This mild method gave quantitative conversions as determined by elemental analy...detailed

Vibrational spectra of Methanesulfonyl chloride (cas 124-63-0) and Methanesulfonyl chloride (cas 124-63-0)-d309/10/2019

The i.r. and Raman spectra of methanesulfonyl chloride and methanesulfonyl chloride-d3 have been recorded in the liquid state, and consistent assignments of the fundamental frequencies of the two isotopic compounds have been given. The normal coordinate calculation based on a modified Urey—Brad...detailed

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