124-63-0

Basic information

• Product Name: Methanesulfonyl chloride
• Synonyms: Methane sufonyl chloride;124-63-0;Methanesulfonyl chloride###124-63-0;AKOS BBS-00004350;METHYLSULFOCHLORIDE;METHYLSULFONYL CHLORIDE;MESYL CHLORIDE;METHANESULFONYL CHLORIDE
• CAS NO: 124-63-0
• Molecular Formula: CH3ClO2S
• Molecular Weight: 114.55132
• EINECS: 204-706-1
• Product Categories: Organics;Pharmaceutical Intermediates
• Mol File: 124-63-0.mol

Chemical Properties

• Melting Point: -33°C
• Boiling Point: 60 °C21 mm Hg(lit.)
• Flash Point: >230 °F
• Appearance: Clear/Liquid
• Density: 1.48 g/mL at 25 °C(lit.)
• Refractive Index: n20/D 1.452(lit.)
• Storage Temp.: Store at R.T.
• Water Solubility: Miscible with alcohol, ether and organic solvents. Immiscible with water.
• Sensitive: Moisture Sensitive
• Merck: 14,5955
• BRN: 506297
• CAS DataBase Reference: Methanesulfonyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: Methanesulfonyl chloride(124-63-0)
• EPA Substance Registry System: Methanesulfonyl chloride(124-63-0)

Safety Data

• Hazard Codes: T+,T,C
• Statements: 24/25-26-34-37-35-22-41
• Safety Statements: 26-28-36/37/39-45-25-28A
• RIDADR: UN 3246 6.1/PG 1
• WGK Germany: 2
• RTECS: PB2790000
• TSCA: Yes
• HazardClass: 6.1
• PackingGroup: I
• Hazardous Substances Data: 124-63-0(Hazardous Substances Data)

Usage

Reactivity Profile

Methanesulfonyl chloride reacts vigorously with water, steam, alkali, methylformamide. Emits toxic fumes of chloride and oxides of sulfur when heated to decomposition. A dangerous storage hazard. Reacts explosively with dimethyl sulfoxide [Buckley, A., J. Chem. Educ., 1965, 42, p. 674]. May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291].

Chemical Properties

Colorless to yellow liquid

Purification Methods

Distil the sulfonyl chloride from P2O5 under vacuum. It is a strong IRRITANT.[Beilstein 4 IV 27.]

General Description

A pale yellow corrosive liquid. More dense than water and insoluble in water. Very toxic by ingestion, inhalation, or skin absorption.

Health Hazard

TOXIC; inhalation, ingestion or contact (skin, eyes) with vapors, dusts or substance may cause severe injury, burns or death. Contact with molten substance may cause severe burns to skin and eyes. Reaction with water or moist air will release toxic, corrosive or flammable gases. Reaction with water may generate much heat that will increase the concentration of fumes in the air. Fire will produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.

Fire Hazard

Combustible material: may burn but does not ignite readily. Substance will react with water (some violently) releasing flammable, toxic or corrosive gases and runoff. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapors may travel to source of ignition and flash back. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated or if contaminated with water.

Uses

In the synthesis of photographic and agricultural chemicals, pharmaceutical intermediates. As a stabilizer; catalyst; curing and chlorinating agent; precursor to methanesulfonic acid.

InChI:InChI=1/CH3ClO2S/c1-5(2,3)4/h1H3

Upstream product

• 8042-47-5 Mineral oil 
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• 62-56-6 Thiocarbamide 
• 624-92-0 Dimethyl disulfide 
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Downstream Products

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• 60282-87-3 Gestodene 
• 66104-22-1 Pergolide 
• 105889-45-0 Cefcapene pivoxil 
• 83799-24-0 Fexofenadine 
• 3056-17-5 Stavudine 
• 32305-98-9 (-)-DIOP 
• 66852-54-8 Halobetasol propionate 
• 22373-75-7 (4S)-HYDROXY-3-METHYL-2-(2-PROPENYL)-2-CYCLOPENTENE-1-ONE 
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• 1120-71-4 1,3-Propanesultone 
• 99724-19-3 3-N-Boc-aminopyrrolidine 
• 62-50-0 Ethyl methanesulfonate 
• 55-98-1 Busulfan 
• 74397-12-9 LIMAPROST 
• 7151-76-0 4-(METHANESULFONYLAMINO)BENZOIC ACID 
• 37045-73-1 N-(3-Aminophenyl)methanesulfamide 
• 110588-57-3 SAPERCONAZOLE 
• 122536-76-9 (S)-3-(Boc-amino)pyrrolidine 
• 77087-34-4 (4S)-4-hydroxy-3-methyl-2-prop-2-ynyl-cyclopent-2-en-1-one 
• 2707-37-1 9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione21-phosphate piperazine salt 
• 61478-28-2 (2S,4S)-(-)-N-BOC-4-Diphenylphosphino-2-diphenylphosphinomethyl-pyrrolidine 
• 15722-48-2 OLSALAZINE 
• 66-27-3 Methyl methanesulfonate 
• 4455-15-6 ETHYL METHANESULFONYLACETATE 
• 51264-14-3 Amsacrine 
• 156517-64-5 (3S,4S)-(-)-1-BENZYL-3,4-BIS(DIPHENYLPHOSPHINO)PYRROLIDINE 
• 28547-13-9 3-(METHANESULFONYLAMINO)BENZOIC ACID 
• 89-57-6 5-Aminosalicylic acid 
• 53250-82-1 4-(Methylsulfonamido)aniline 
• 3144-09-0 Methanesulfonamide 
• 84449-90-1 Raloxifene 

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