Photoinduced Palladium-Catalyzed Intermolecular Radical Cascade Cyclization of N-Arylacrylamides with Unactivated Alkyl Bromides
A mild visible-light-induced Pd-catalyzed intermolecular radical cascade reaction of N-arylacrylamides with unactivated alkyl bromides is disclosed. Photoexcited Pd complexes transfer a single electron in this protocol, and hybrid alkyl Pd-radical species
Du, Juan,Wang, Xing,Wang, Hongling,Wei, Jinhu,Huang, Xuan,Song, Jun,Zhang, Junmin
supporting information
p. 5631 - 5635
(2021/07/31)
Visible-light-induced deboronative alkylarylation of acrylamides with organoboronic acids
A visible-light-induced deboronative alkylarylation of acrylamides with organoboronic acids was developed. In this transformation, boronic acids could be activated by the organic photocatalyst of eosin Y, generating alky free radicals in high efficiency.
Li, Xuezhi,Han, Man-Yi,Wang, Bin,Wang, Lei,Wang, Min
supporting information
p. 6612 - 6619
(2019/07/16)
A antibacterial indole preparation method (by machine translation)
The invention discloses a antibacterial indole preparation method, in particular to to activate the olefin as the substrate of reaction, to palladium metal compound as a catalyst, in order to dppf as a ligand, to undifferentiated as the alkylating agent,
-
Paragraph 0023
(2019/02/06)
Molecular Oxygen-Promoted General and Site-Specific Alkylation with Organoboronic Acid
A general alkylating method using organoboronic acid under 1 atm of oxygen is developed. It allows a facile access to a wide range of functionalized molecules with privileged scaffolds in drugs and natural products such as oxindoles, quinolinones, chromon
Palladium-catalyzed alkylarylation of acrylamides with unactivated alkyl halides
An efficient palladium-catalyzed alkylarylation of acrylamides with unactivated alkyl halides has been developed. This method is highlighted by its broad substrate scope and excellent functional group tolerance. In addition to alkyl halides, fluoroalkyl halides and benzyl bromides also participated well in this transformation. A detailed mechanistic investigation suggests that a radical pathway is probably involved in the cyclization process.
Wang, Hua,Guo, Li-Na,Duan, Xin-Hua
p. 860 - 867
(2016/02/18)
Free-radical cascade Alkylarylation of Alkenes with simple Alkanes: Highly efficient access to Oxindoles via selective (sp3)C-H and (sp 2)C-H Bond functionalization
A copper-catalyzed alkylarylation of alkenes with simple alkanes was achieved, which not only provided an efficient method to prepare various alkyl-substituted oxindoles, but also represented a novel strategy for selective sp3 C-H functionalization/C-C bond formation via a free-radical cascade process. Additionally, selective activation of unactivated (sp 3)C-H and (sp2)C-H bonds by one single step is achieved in this system, which would also provide a novel strategy for raising efficiency in C-H bond functionalization.