1512858-84-2Relevant academic research and scientific papers
Photoinduced Palladium-Catalyzed Intermolecular Radical Cascade Cyclization of N-Arylacrylamides with Unactivated Alkyl Bromides
Du, Juan,Wang, Xing,Wang, Hongling,Wei, Jinhu,Huang, Xuan,Song, Jun,Zhang, Junmin
supporting information, p. 5631 - 5635 (2021/07/31)
A mild visible-light-induced Pd-catalyzed intermolecular radical cascade reaction of N-arylacrylamides with unactivated alkyl bromides is disclosed. Photoexcited Pd complexes transfer a single electron in this protocol, and hybrid alkyl Pd-radical species
A antibacterial indole preparation method (by machine translation)
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Paragraph 0023, (2019/02/06)
The invention discloses a antibacterial indole preparation method, in particular to to activate the olefin as the substrate of reaction, to palladium metal compound as a catalyst, in order to dppf as a ligand, to undifferentiated as the alkylating agent,
Visible-light-induced deboronative alkylarylation of acrylamides with organoboronic acids
Li, Xuezhi,Han, Man-Yi,Wang, Bin,Wang, Lei,Wang, Min
supporting information, p. 6612 - 6619 (2019/07/16)
A visible-light-induced deboronative alkylarylation of acrylamides with organoboronic acids was developed. In this transformation, boronic acids could be activated by the organic photocatalyst of eosin Y, generating alky free radicals in high efficiency.
Molecular Oxygen-Promoted General and Site-Specific Alkylation with Organoboronic Acid
Ling, Anbo,Zhang, Lizhi,Tan, Ren Xiang,Liu, Zhong-Quan
, p. 14489 - 14497 (2018/12/14)
A general alkylating method using organoboronic acid under 1 atm of oxygen is developed. It allows a facile access to a wide range of functionalized molecules with privileged scaffolds in drugs and natural products such as oxindoles, quinolinones, chromon
Palladium-catalyzed alkylarylation of acrylamides with unactivated alkyl halides
Wang, Hua,Guo, Li-Na,Duan, Xin-Hua
, p. 860 - 867 (2016/02/18)
An efficient palladium-catalyzed alkylarylation of acrylamides with unactivated alkyl halides has been developed. This method is highlighted by its broad substrate scope and excellent functional group tolerance. In addition to alkyl halides, fluoroalkyl halides and benzyl bromides also participated well in this transformation. A detailed mechanistic investigation suggests that a radical pathway is probably involved in the cyclization process.
Free-radical cascade Alkylarylation of Alkenes with simple Alkanes: Highly efficient access to Oxindoles via selective (sp3)C-H and (sp 2)C-H Bond functionalization
Li, Zejiang,Zhang, Ye,Zhang, Lizhi,Liu, Zhong-Quan
supporting information, p. 382 - 385 (2014/04/03)
A copper-catalyzed alkylarylation of alkenes with simple alkanes was achieved, which not only provided an efficient method to prepare various alkyl-substituted oxindoles, but also represented a novel strategy for selective sp3 C-H functionalization/C-C bond formation via a free-radical cascade process. Additionally, selective activation of unactivated (sp 3)C-H and (sp2)C-H bonds by one single step is achieved in this system, which would also provide a novel strategy for raising efficiency in C-H bond functionalization.
