151392-10-8

Basic information

• Product Name: N-[4-(2-{2-[(4-methoxyanilino)carbothioyl]hydrazino}-2-oxoethoxy)phenyl]acetamide
• Synonyms: N-[4-(2-{2-[(4-methoxyanilino)carbothioyl]hydrazino}-2-oxoethoxy)phenyl]acetamide
• CAS NO: 151392-10-8
• Molecular Formula: C₁₈H₂₀N₄O₄S
• Molecular Weight: 388.45
• Mol File: 151392-10-8.mol

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.352g/cm³
• Refractive Index: 1.666
• CAS DataBase Reference: N-[4-(2-{2-[(4-methoxyanilino)carbothioyl]hydrazino}-2-oxoethoxy)phenyl]acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[4-(2-{2-[(4-methoxyanilino)carbothioyl]hydrazino}-2-oxoethoxy)phenyl]acetamide(151392-10-8)
• EPA Substance Registry System: N-[4-(2-{2-[(4-methoxyanilino)carbothioyl]hydrazino}-2-oxoethoxy)phenyl]acetamide(151392-10-8)

Safety Data

• Hazardous Substances Data: 151392-10-8(Hazardous Substances Data)

Usage

InChI:InChI=1/C18H20N4O4S/c1-12(23)19-13-5-9-16(10-6-13)26-11-17(24)21-22-18(27)20-14-3-7-15(25-2)8-4-14/h3-10H,11H2,1-2H3,(H,19,23)(H,21,24)(H2,20,22,27)

Upstream product

• 103-90-2 4-acetaminophenol 
• 67202-81-7 ethyl 2-[4-(acetylamino)phenoxy]acetate 
• 75129-75-8 N‐(4‐(2‐hydrazinyl‐2‐oxoethoxy)phenyl) acetamide 
• 2284-20-0 4-Methoxyphenyl isothiocyanate 

Relevant articles and documents

Synthesis and antibacterial activity of a series 1-aryl-2-mercapto-5--1,3,4-triazoles, thiadiazoles and 2--3,4,5-trisubstituted pyrazoles

A series of new 1-aryl-2-mercapto-5--1,3,4-triazoles, 2-arylamino-5--1,3,4-thiadiazoles, p-acetamido(phenoxy)acetyl thio-semicarbazides and 2--3-amino-4-carboxamido-5-methylthiopyrazole have been prepared and evaluated for comparative antibacterial activity.The antibacterial activity of the target compounds and their relevant reference agent have been determined in vitro using serial 2-fold dilution technique on an assortment of Gram negative and Gram positive organisms.It has been observed that the in vitro antibacterial activity of cyclized 1,3,4-triazoles and 1,3,4-thiadiazoles are significantly greater than thiosemicarbazides.The derivatives 4b, 5b have better in vitro antibacterial activity.

Anti-inflammatory activity of substituted 1,3,4-oxadiazoles

Various 5-[[(acetamidophen-4-yl)oxy]methyl]-2-(p-substituted phenylamino)- 1,3,4-oxadiazoles (4a-4d) were synthesized by cyclization of the corresponding N1-[[(acetamidophen-4-yl)oxy]acetyl]-N4-(p-substituted phenylamino)-3-thiosemicarbazides (3a-3d). All four of the thiosemicarbazides [250 mg/kg, orally (p.o.)] and the corresponding oxadiazoles (250 mg, p.o.) possessed anti-inflammatory activity. In the Carrageenan-induced edema test in rat paw, the activity ranged from 28 to 47% for 3a-3d and 44 to 63% for 4a-4d, with indomethacin (10 mg/kg, p.o.), used as the standard reference drug, showing 88.5% protection. The compounds (1 mM) were also tested for the inhibition of bovine serum albumin denaturation, and this activity ranged from 27 to 68%. No correlation was seen between the anti-inflammatory activity of 3a-4d and the inhibition of denaturation of bovine serum albumin. The low toxicity of these compounds was reflected by their high approximate 50% lethal dose (LD50) values, ranging from 2000 to 2500 mg/kg.