151409-82-4

Basic information

• Product Name: 1-(2-METHOXY-ETHYL)-1H-INDOLE-3-CARBALDEHYDE
• Synonyms: TIMTEC-BB SBB011056;1-(2-METHOXY-ETHYL)-1H-INDOLE-3-CARBALDEHYDE
• CAS NO: 151409-82-4
• Molecular Formula: C12H13NO2
• Molecular Weight: 203.24
• Mol File: 151409-82-4.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-(2-METHOXY-ETHYL)-1H-INDOLE-3-CARBALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-METHOXY-ETHYL)-1H-INDOLE-3-CARBALDEHYDE(151409-82-4)
• EPA Substance Registry System: 1-(2-METHOXY-ETHYL)-1H-INDOLE-3-CARBALDEHYDE(151409-82-4)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22
• HazardClass: IRRITANT
• Hazardous Substances Data: 151409-82-4(Hazardous Substances Data)

Usage

Indole derivative

Aldehyde
It is derived from the indole heterocyclic aromatic compound by attaching an aldehyde functional group to the 3-position of the indole ring.

Methoxyethyl group

2-position of the indole ring
The presence of a methoxyethyl group at the 2-position of the indole ring gives 1-(2-METHOXY-ETHYL)-1H-INDOLE-3-CARBALDEHYDE its unique properties and reactivity.

Pharmaceutical synthesis

Intermediate
It is frequently used as an intermediate in the synthesis of various pharmaceuticals, indicating its importance in the development of new drugs.

Agrochemical synthesis

Intermediate
It is also used as an intermediate in the synthesis of agrochemicals, which are chemicals used in the agricultural industry.

Organic compound synthesis

Building block
Its versatile reactivity and ability to undergo a variety of chemical reactions make it a valuable building block for the construction of complex organic molecules.

Heterocyclic aromatic compound

Indole
The indole ring is a heterocyclic aromatic compound, which contributes to the compound's unique properties and reactivity.

Chemical reactions

Versatile reactivity
The compound can participate in various chemical reactions, making it a useful tool in organic synthesis and the development of new compounds.

Upstream product

• 487-89-8 Indole-3-carboxaldehyde 
• 6482-24-2 2-Bromoethyl methyl ether 
• 627-42-9 2-chloroethyl methyl ether 

Relevant articles and documents

3, 4 - SUBSTITUTED PIPERIDINE DERIVATIVES AS RENIN INHIBITORS

The present invention relates to 3,4-substituted piperidinyl - based renin inhibitor compounds bearing at 4-position lsoqumolone and having the Formula (I) : The invention further relates to pharmaceutical compositions containing said compounds, as well a

3, 4 - SUBSTITUTED PIPERIDINE DERIVATIVES AS RENIN INHIBITORS

The present invention relates to 3,4-substituted piperidinyl-based renin inhibitor compounds bearing at 4-position oxopyridine and having the formula (I). The invention further relates to pharmaceutical compositions containing said compounds, as well as their use in treating cardiovascular events and renal insufficiency.

3,4,(5)-SUBSTITUTED TETRAHVDROPYRIDINES

Organic Compounds 3,4(,5)-substituted tetrahydropyridine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease that depends on activity of renin; the use of a compound of that class for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on activity of renin; the use of a compound of that class in the treatment of a disease that depends on activity of renin; pharmaceutical formulations comprising a 3,4(,5)- substituted tetrahydropyridine compound, and/or a method of treatment comprising administering a 3,4(,5)-substituted tetrahydropyridine compound, a method for the manufacture of a 3,4(,5)- substituted tetrahydropyridine compound, and novel intermediates and partial steps for its synthesis. The 3,4(,5)- substituted tetrahydropyridine compounds have the formula I wherein the substituents and symbols are as described in the specification.

N6-Substituted Adenosine Receptor Agonists. Synthesis and Pharmacological Activity as Potent Antinociceptive Agents

Novel N6-(indol-3-yl)alkyl derivatives of adenosine were synthesized.The adenosine receptor affinity and the antinociceptive activity of these compounds were assessed in binding studies and the phenylbenzoquinone-induced writhing test.Most of these analogues exhibited a potent analgesic activity without side effects.Among them, compound 3c (UP 202-32) bound to A1 (Ki = 110 nM) and A2 (Ki = 350 nM) adenosine receptors in a specific manner since it did not interact with many other receptors, especially opioid binding sites.The antinociceptive activity in the phenylbenzoquinone assay (ED50 = 3.3 mg/kg po) was antagonized by 8-cyclopentyltheophylline, suggesting that an adenosinergic mechanism underlies the analgesic activity observed with this compound.The data obtained with these new N6-substituted adenosine receptor agonists emphasize the interest of such compounds in the treatment of pain.