151427-19-9

Basic information

• Product Name: 2-BROMO-1-(2,3-DIHYDRO-1-BENZOFURAN-5-YL)ETHANONE
• Synonyms: 2-broMo-1-(2,3-dihydrobenzofuran-5-yl)ethanone;2-bromo-1-(2,3-dihydro-1-benzofuran-5-yl)ethan-1-one
• CAS NO: 151427-19-9
• Molecular Formula: C₁₀H₉BrO₂
• Molecular Weight: 241.09
• Mol File: 151427-19-9.mol

Chemical Properties

• Boiling Point: 356.4°Cat760mmHg
• Flash Point: 169.3°C
• Appearance: /
• Density: 1.562g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.606
• CAS DataBase Reference: 2-BROMO-1-(2,3-DIHYDRO-1-BENZOFURAN-5-YL)ETHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BROMO-1-(2,3-DIHYDRO-1-BENZOFURAN-5-YL)ETHANONE(151427-19-9)
• EPA Substance Registry System: 2-BROMO-1-(2,3-DIHYDRO-1-BENZOFURAN-5-YL)ETHANONE(151427-19-9)

Safety Data

• Hazardous Substances Data: 151427-19-9(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
2-BROMO-1-(2,3-DIHYDRO-1-BENZOFURAN-5-YL)ETHANONE is used as a building block in organic synthesis for the preparation of various pharmaceuticals and natural products. Its unique structure and functional groups make it a valuable component in the creation of complex organic molecules.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 2-BROMO-1-(2,3-DIHYDRO-1-BENZOFURAN-5-YL)ETHANONE is utilized as a key intermediate for the development of new drugs. Its presence in the molecular structure can contribute to the desired pharmacological properties, such as improved potency, selectivity, and bioavailability.
Used in Biological Activity Research:
2-BROMO-1-(2,3-DIHYDRO-1-BENZOFURAN-5-YL)ETHANONE is studied for its potential biological activities, including antifungal and antibacterial properties. This makes it a promising candidate for the development of new antimicrobial agents to combat drug-resistant infections.
Used in Agrochemical Development:
This chemical compound also plays an important role in the development of new agrochemicals. Its potential biological activities can be harnessed to create effective pesticides, fungicides, or other agricultural products that protect crops and enhance agricultural productivity.
Used in the Preparation of Aromatic Ethers:
2-BROMO-1-(2,3-DIHYDRO-1-BENZOFURAN-5-YL)ETHANONE is a useful reagent in the synthesis of aromatic ethers, which are important intermediates in various chemical reactions and have applications in the production of pharmaceuticals, fragrances, and other specialty chemicals.

InChI:InChI=1/C10H9BrO2/c11-6-9(12)7-1-2-10-8(5-7)3-4-13-10/h1-2,5H,3-4,6H2

Upstream product

• 496-16-2 2.3-dihydrobenzofuran 
• 22118-09-8 2-bromoacetyl chloride 
• 90843-31-5 1-(2,3-dihydrobenzofuran-5-yl)ethanone 

Downstream Products

• 133099-07-7 (S)-darifenacin hydrobromide 
• 127264-14-6 2,3-dihydro-5-(2-bromoethyl)benzofuran 
• 133099-04-4 darifenacin 
• 262847-54-1 2,3-dihydrobenzofuran-5-carboxamide 

Relevant articles and documents

ANTIBACTERIAL COMPOUNDS

The present invention relates to compounds of general formula (II),to compositions comprising these compounds and to methods of treating Enterobacteriaceae bacterial diseases and infections using the compounds. The compounds find application in the treatment of infection with, and diseases caused by, Enterobacteriaceae.

One-Pot Preparation of Aromatic Amides, 4-Arylthiazoles, and 4-Arylimidazoles from Arenes

Simple treatment of arenes with α-bromoacetyl chloride and AlCl3, followed by the reaction with molecular iodine and aq. NH3, thioamides, or amidines gave the corresponding primary aromatic amides, 4-arylthiazoles, or 4-arylimidazoles in good yields, respectively. Aryl α-bromomethyl ketones are the key intermediates in those reactions. Primary aromatic amides were formed from arenes through the reaction of aryl α-bromomethyl ketones with molecular iodine and aq. NH3, and 4-arylthiazoles and 4-arylimidazoles were formed from arenes through the reactions of aryl α-bromomethyl ketones with thioamides and amidines, respectively, in one pot under transition-metal-free conditions.

Design, synthesis and structure-activity relationship studies of novel and diverse cyclooxygenase-2 inhibitors as anti-inflammatory drugs

Because of the pivotal role of cyclooxygenase (COX) in the inflammatory processes, non-steroidal anti-inflammatory drugs (NSAIDs) that suppress COX activities have been used clinically for the treatment of inflammatory diseases/syndromes; however, traditional NSAIDs exhibit serious side-effects such as gastrointestinal damage and hyper sensitivity owing to their COX-1 inhibition. Also, COX-2 inhibition-derived suppressive or preventive effects against initiation/proliferation/invasion/motility/recurrence/metastasis of various cancers/tumours such as colon, gastric, skin, lung, liver, pancreas, breast, prostate, cervical and ovarian cancers are significant. In this study, design, synthesis and structure-activity relationship (SAR) of various novel {2-[(2-, 3- and/or 4-substituted)-benzoyl, (bicyclic heterocycloalkanophenyl)carbonyl or cycloalkanecarbonyl]-(5- or 6-substituted)-1H-indol-3-yl}acetic acid analogues were investigated to seek and identify various chemotypes of potent and selective COX-2 inhibitors for the treatment of inflammatory diseases, resulting in the discovery of orally potent agents in the peripheral-inflammation model rats. The SARs and physicochemical properties for the analogues are described as significant findings. For graphical abstract: see Supplementary Material. (www.informahealthcare.com/enz)

A new solvent system (Cyclopentyl methyl ether-water) in process development of darifenacin HBr

Darifenacin is a potent and competitive M3 selective receptor antagonist (M3SRA), and its hydrobromide salt (1) is the active ingredient of pharmaceutical formulations for oral treatment of urinary incontinence. The present work demonstrates an efficient, commercial manufacturing process for darifenacin hydrobromide (1).

DIAMINOTHIAZOLES

The present invention is directed to novel diaminothiazoles of formula These compounds inhibit cyclin-dependent kinase 4 (Cdk4) and are selective against Cdk2 and Cdk1. These compounds and their pharmaceutically acceptable salts and esters have antiproliferative activity and are useful in the treatment or control of cancer, in particular solid tumors. This invention is also directed to pharmaceutical compositions containing such compounds and to methods of treating or controlling cancer, most particularly the treatment 6r control of breast, lung and colon and prostate tumors.

Bicycliccarbonyl indole compounds as anti-inflammatory/analgesic agents

This invention provides a compound of the following formula: or the pharmaceutically acceptable salts thereof wherein A is C1-6alkylene or —NR1—; Z is C(═L)R2, or SO2R3; U is CH or N; W and Y are inde

Syntheses and Photophysical Properties of Some 5(2)-Aryl-2(5)-(4-pyridyl)oxazoles and Related Oxadiazoles and Furans

A number of 5-aryl-2-(4-pyridyl)oxazoles, a 2-aryl-5-(4-pyridyl)oxazole, the related oxadiazole and furan, several 2-(4-pyridyl)cycloalkanooxazoles, and many of their quaternary salts were prepared.No single standard synthesis was effective for preparation of more than a few of the 25 free bases described; methods often unique to a base were employed.Minor variations in structure sometimes produced large differences in absorption and emission wavelengths, as well as in the magnitude of the extinction coefficient.The salts are of interest as laser dyes, scintillation fluors, biological stains, and shifters for luminescent solar concentrators.