Welcome to LookChem.com Sign In|Join Free

CAS

  • or
10-Dehydrobaccatin V is a naturally occurring compound that serves as a key intermediate in the biosynthesis of paclitaxel, a widely used chemotherapeutic drug. It is derived from the yew tree and has gained significant attention due to its potential role in the production of paclitaxel and its derivatives.

151636-94-1 Suppliers

Post Buying Request

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier
  • 151636-94-1 Structure
  • Basic information

    1. Product Name: 10-Dehydrobaccatin V
    2. Synonyms: (2aR,4R,4aS,9S,11S,12S,12aR,12bS)-12b-(Acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,9,10,11,12,12a,12b-decahydro-4,9,11-trihydroxy-4a,8,13,13-tetraMethyl-7,11-Methano-1H-cyclodeca[3,4]benz[1,2-b]oxete-5,6-dione;10-Deacetyl-10-oxo-baccatin V;10-Dehydrobaccatin V;7-epi-10-Oxo-10-deacetyl Baccatin III
    3. CAS NO:151636-94-1
    4. Molecular Formula: C29H34O10
    5. Molecular Weight: 542.57426
    6. EINECS: N/A
    7. Product Categories: Chiral Reagents;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
    8. Mol File: 151636-94-1.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
    8. Solubility: Chloroform (Slightly), Methanol (Slightly)
    9. Stability: Hygroscopic
    10. CAS DataBase Reference: 10-Dehydrobaccatin V(CAS DataBase Reference)
    11. NIST Chemistry Reference: 10-Dehydrobaccatin V(151636-94-1)
    12. EPA Substance Registry System: 10-Dehydrobaccatin V(151636-94-1)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 151636-94-1(Hazardous Substances Data)

151636-94-1 Usage

Uses

Used in Pharmaceutical Industry:
10-Dehydrobaccatin V is used as a precursor in the production of paclitaxel and its derivatives for [application reason] the development of anticancer drugs. Its role in the biosynthesis of paclitaxel makes it a valuable compound for the pharmaceutical industry, as it can potentially streamline the production process and increase the availability of this essential drug.
Used in Research and Development:
10-Dehydrobaccatin V is used as a research compound for [application reason] the study of its chemical properties, biosynthetic pathways, and potential applications in the development of new drugs and therapies. Its unique structure and role in the production of paclitaxel make it an interesting subject for scientific investigation.
Used in Quality Control:
10-Dehydrobaccatin V is used as a reference material for [application reason] quality control and assurance in the production of paclitaxel and its derivatives. As an impurity of paclitaxel, it is essential to monitor and control its presence in the final product to ensure the safety and efficacy of the drug.

Check Digit Verification of cas no

The CAS Registry Mumber 151636-94-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,1,6,3 and 6 respectively; the second part has 2 digits, 9 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 151636-94:
(8*1)+(7*5)+(6*1)+(5*6)+(4*3)+(3*6)+(2*9)+(1*4)=131
131 % 10 = 1
So 151636-94-1 is a valid CAS Registry Number.

151636-94-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 7-epi-10-Oxo-10-deacetyl Baccatin III

1.2 Other means of identification

Product number -
Other names 10-Dehydrobaccatin V

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:151636-94-1 SDS

151636-94-1Upstream product

151636-94-1Downstream Products

151636-94-1Relevant articles and documents

Anomalous microbial transformations on the taxane ring of 10-DAB by a strain of the fungus Curvularia lunata: Transbenzoylation, transacetylation, and opening of the oxetane ring

Arnone, Alberto,Bava, Adriana,Fronza, Giovanni,Nasini, Gianluca

, p. 2000 - 2004 (2009)

The fermentation of 10-deacetylbaccatin III (10-DAB) (1) with Curvularia lunata afforded the taxane hemiacetals 2a and 3, characterized by extensive structural modification, including C-2 to C-1 transbenzoylation, oxidation of the C-2 hydroxyl, formation

PROCESSES FOR TAXANE DERIVATIVES AND INTERMEDIATES USEFUL THEREIN

-

Page/Page column 31-32, (2008/06/13)

The application provides a process for the preparation of taxane derivatives and intermediates useful in such processes.

The Reductive Fragmentation of 7-Hydroxy-9,10-dioxotaxoids

Appendino, Giovanni,Noncovich, Alain,Bettoni, Piergiorgio,Dambruoso, Paolo,Sterner, Olov,Fontana, Gabriele,Bombardelli, Ezio

, p. 4422 - 4431 (2007/10/03)

The retro-aldol reductive fragmentation of different structural types of 7-hydroxy-9,10-dioxotaxoids was investigated, showing that the reaction is typical of taxanes and requires cerium(III) promotion with NaBH4 in protic medium and alkylboron (aluminium) hydrides in aprotic solvents. The resulting 7,8-seco-taxanes are key intermediates for the synthesis of a novel class of anticancer taxanes endowed with a unique pattern of in vivo biological activity. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003.

Synthesis of modified baccatins via an oxidation-reduction protocol

Appendino, Giovanni,Jakupovic, Jasmin,Cravotto, Giancarlo,Enriu, Renata,Varese, Marcella,Bombardelli, Ezio

, p. 3233 - 3236 (2007/10/02)

(12R)-7-trietylsilyl-11-dihydro-10-deacetylbaccatin III (2), -deacetylbaccatin III (4) and the 7,8-seco baccatin III (5a) were synthesized from 10-deacetylbaccatin III via an oxidation-reduction protocol.

THE CHEMISTRY AND OCCURRENCE OF TAXANE DERIVATIVES. XIII. THE OXIDATION OF 10-DEACETYLBACCATIN III

Appendino, Giovanni,Fenoglio, Ivana,Cravotto, Giancarlo,Varese, Marcella,Gariboldi, Pierluigi,Gabetta, Bruno

, p. 253 - 258 (2007/10/02)

The three secondary hydroxyls of 10-deacetylbaccatin III, 1, can be selectively oxidized.However, only the 13-dehydro derivative is stable under the reaction conditions, whereas the 10- and the 7-dehydro derivatives undergo epimerization at C-7 and oxetan

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 151636-94-1