151978-97-1

Basic information

• Product Name: 2-(4-Iodo-phenoxy)-ethylaMine
• Synonyms: 2-(4-Iodo-phenoxy)-ethylaMine;2-(4-Iodophenoxy)ethanamine
• CAS NO: 151978-97-1
• Molecular Formula: C₈H₁₀INO
• Molecular Weight: 263.07557
• Mol File: 151978-97-1.mol

Chemical Properties

• Boiling Point: 312.9±27.0 °C(Predicted)
• Appearance: /
• Density: 1.689±0.06 g/cm3(Predicted)
• PKA: 8.36±0.10(Predicted)
• CAS DataBase Reference: 2-(4-Iodo-phenoxy)-ethylaMine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-Iodo-phenoxy)-ethylaMine(151978-97-1)
• EPA Substance Registry System: 2-(4-Iodo-phenoxy)-ethylaMine(151978-97-1)

Safety Data

• Hazardous Substances Data: 151978-97-1(Hazardous Substances Data)

Usage

Appearance

White to off-white solid

Solubility

Soluble in various organic solvents

Derivatives

4-iodophenol and ethylamine

Uses

Building block in organic synthesis, starting material for pharmaceuticals and agrochemicals, potential medical treatment (requires further research)

Pharmacological properties

Not fully understood, requires further research.

Upstream product

• 151978-98-2 tert-butyl N-(2-(4-iodophenoxy)ethyl)carbamate 
• 540-38-5 p-Iodophenol 
• 88497-17-0 dimercaptopropane 
• 1517-05-1 2-azidoethanol 
• 1972-28-7 diethylazodicarboxylate 
• 855482-23-4 2-(4-iodophenoxy)ethan-1-amine hydrochloride 
• 651330-71-1 C₁₆H₁₂INO₃ 

Downstream Products

• 151978-98-2 tert-butyl N-(2-(4-iodophenoxy)ethyl)carbamate 
• 651330-72-2 C₁₆H₁₄ClNO 
• 651330-73-3 C₂₈H₃₀ClNO₃ 
• 651330-74-4 C₂₄H₂₀ClNO₂ 

Relevant articles and documents

ESTROGEN RECEPTOR ANTAGONIST

Provided is an indole compound. In particular, disclosed are a compound represented by formula (II) or an isomer or pharmaceutically acceptable salt thereof and a use of the same as an estrogen receptor antagonist in preparing a drug for treating estrogen receptor-positive breast cancer.

SALTS OF INDAZOLE DERIVATIVE AND CRYSTALS THEREOF

The present invention provides salts of (E)-N,N-dimethyl-4-((2-((5-((Z)-4,4,4-trifluoro-1-(3-fluoro-1H-indazol-5-yl)-2-phenylbut-1-en-1-yl)pyridin-2-yl)oxy)ethyl)amino)but-2-enamide represented by the formula I and acids, and crystals thereof, possessing a potential to be used as drug substance in pharmaceuticals.

TETRASUBSTITUTED ALKENE COMPOUNDS AND THEIR USE

Disclosed herein are compounds, or pharmaceutically acceptable salts thereof, and methods of using the compounds for treating breast cancer by administration to a subject in need thereof a therapeutically effective amount of the compounds or pharmaceutically acceptable salts thereof. The breast cancer may be an ER-positive breast cancer and/or the subject in need of treatment may express a mutant ER-α protein.

TETRASUBSTITUTED ALKENE COMPOUNDS AND THEIR USE

Disclosed herein are compounds, or pharmaceutically acceptable salts thereof, and methods of using the compounds for treating breast cancer by administration to a subject in need thereof a therapeutically effective amount of the compounds or pharmaceutically acceptable salts thereof. The breast cancer may be an ER-positive breast cancer and/or the subject in need of treatment may express a mutant ER-α protein.

Acetylenic compound useful in treating inflammatory disorders

This invention is directed to acetylenic compounds as inhibitors of a nicotinamide adenine dinucleotide oxidase hydride donor useful in treating or ameliorating a reactive oxygen species mediated inflammatory disorder.

Aminoalcohol derivatives

The present invention relates to a compound formula[I]: wherein X is bond, —CH2—, —O— or —NH—, R1 and R12 are each independently hydrogen, halogen, lower alkyl, etc., R2 is hydrogen or optionally substituted lower alkyl, R3 is hydrogen or an amino protective group, R4, R5 and R6 are each independently hydrogen or optionally substituted lower alkyl, R7 is -Z-R13, in which Z is bond, etc., and R13 is carboxy, lower alkoxycarbonyl, (lower alkylsulfonyl)carbamoyl or lower alkanoylsulfamoyl, R8 is —Y—R9, in which Y is bond, —CH2—, —O—, —S—, etc., and R9 is hydrogen, lower alkyl, cyclo(lower)alkyl, etc., and R11 is hydrogen, lower alkyl, lower alkoxy, etc., or a salt thereof. The compound [I] of the present invention and pharmaceutically acceptable salts thereof are useful for the prophylactic and/or the therapeutic treatment of pollakiurea or urinary incontinence.

ACETYLENIC COMPOUNDS USEFUL IN TREATING INFLAMMATORY DISORDERS

This invention is directed to acetylenic compounds as inhibitors of a nicotinamide adenine dinucleotide oxidase hydride donor useful in treating or ameliorating a reactive oxygen species mediated inflammatory disorders.

Nonpeptidyl platelet aggregation inhibitors having specificity for the GPIIb III receptor

A benzodiazepinedione derivative which acts as a nonpeptidyl platelet aggregation inhibitor is provided. This inhibitor potently inhibits fibrinogen binding to the GPIIb IIIa receptor and is provided in therapeutic compositions for t