540-38-5

Basic information

• Product Name: 4-Iodophenol
• Synonyms: Phenol,p-iodo- (6CI,8CI);1-Iodo-4-hydroxybenzene;4-Hydroxyiodobenzene;4-Hydroxyphenyl iodide;NSC 91464;p-Hydroxyiodobenzene;p-Iodophenol
• CAS NO: 540-38-5
• Molecular Formula: C₆H₅IO
• Molecular Weight: 220.00777
• EINECS: 208-745-5
• Mol File: 540-38-5.mol
• Article Data: 132

Chemical Properties

• Melting Point: 89-94℃
• Boiling Point: 287.2 °C at 760 mmHg
• Flash Point: 112.4 °C
• Appearance: light brown powder
• Density: 2.001 g/cm³
• Vapor Pressure: 0.00146mmHg at 25°C
• Refractive Index: 1.669
• Water Solubility: slightly soluble
• CAS DataBase Reference: 4-Iodophenol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Iodophenol(540-38-5)
• EPA Substance Registry System: 4-Iodophenol(540-38-5)

Safety Data

• Hazard Codes: Xn:Harmful
• Statements: R20/21/22:; R36/37/38:
• Safety Statements: S22:; S26:; S36/37/39:
• Hazardous Substances Data: 540-38-5(Hazardous Substances Data)

Usage

General Description

4-Iodophenol refers to an aromatic organic compound with the molecular structure consisting of a phenol ring bonded with an iodine atom. Its chemical formula is C6H5IO and it is categorized under simple phenols. This chemical compound is prominently used in the field of organic synthesis where it functions as a precursor to various other compounds. 4-Iodophenol is a solid substance at room temperature and can appear as colorless to a very light pinkish color. It requires safe handling as it can be harmful if ingested, inhaled, or comes into contact with skin or eyes.

InChI:InChI=1/C6H5IO/c7-5-1-3-6(8)4-2-5/h1-4,8H

Upstream product

• 33527-94-5 4-acetoxyiodobenzene 
• 1666-13-3 diphenyl diselenide 
• 609-23-4 2,4,6-Triiodophenol 
• 2012-29-5 2,4-diiodophenol 
• 100-66-3 methoxybenzene 
• 109586-39-2 4-iodophenyl trifluoromethanesulfonate 
• 39735-76-7 1-iodo-4-(prop-2-yn-1-yloxy)benzene 
• 108-95-2 phenol 
• 119-30-2 2-hydroxy-5-iodobenzoic acid 
• 637-62-7 p-benzoquinone oxime 
• 104-91-6 p-nitrosophenol 
• 7732-18-5 water 
• 7553-56-2 iodine 
• 7782-68-5 iodic acid 

Downstream Products

• 19578-68-8 4-(4-benzyloxyphenyl) iodide 
• 2628-17-3 4-Vinylphenol 
• 129180-58-1 1-[(1,1-dimethyl-2-propynyl)oxy]-4-iodobenzene 
• 537-14-4 dichlorophenolindophenol 
• 110598-37-3 4-((Z)-1-o-Tolyl-2-trimethylsilanyl-vinyl)-phenol 
• 182758-38-9 1-iodo-4-(S(-)-2-methylbutyloxy)benzene 
• 119152-44-2 Carbonic acid (3S,8S,9S,10R,13R,14S,17R)-17-((R)-1,5-dimethyl-hexyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester 4-iodo-phenyl ester 
• 123266-49-9 7α-<11-(4-iodophenoxy)undecyl>estra-1,3,5(10)-triene-3,17β-diol 
• 15573-67-8 pisolithin A 
• 99-96-7 4-hydroxy-benzoic acid 
• 93790-54-6 [2-(4-iodophenoxy)ethyl]dimethylamine 
• 81233-91-2 4-<2-(diethylamino)ethoxy>iodobenzene 
• 97303-83-8 3-(4-Iodo-phenoxy)-4-methyl-3,6-dihydro-2H-pyran 
• 125718-61-8 (Z)-2-tert-Butoxycarbonylamino-3-(4-hydroxy-phenyl)-acrylic acid benzyl ester 

Relevant articles and documents

-

-

Ni-NiO heterojunctions: a versatile nanocatalyst for regioselective halogenation and oxidative esterification of aromatics

Herein, we report a facile method for the synthesis of Ni-NiO heterojunction nanoparticles, which we utilized for the nuclear halogenation reaction of phenol and substituted phenols usingN-bromosuccinimide (NBS). A remarkablepara-selectivity was achieved for the halogenated products under semi-aqueous conditions. Interestingly, blocking of thepara-position of phenol offeredortho-selective halogenation. In addition, the Ni-NiO nanoparticles catalyzed the oxidative esterification of carbonyl compounds with alcohol, diol or dithiol in the presence of a catalytic amount of NBS. It was observed that the aromatic carbonyls substituted with an electron-donating group favoured nuclear halogenation, whereas an electron-withdrawing group substitution in carbonyl compounds facilitated the oxidation reaction. In addition, the catalyst was magnetically separated and recycled 10 times. The tuned electronic structure at the Ni-NiO heterojunction controlled selectivity and activity as no suchpara-selectivity was observed with commercially available NiO or Ni nanoparticles.

Aryl phenol compound as well as synthesis method and application thereof

The invention discloses a synthesis method of an aryl phenol compound shown as a formula (3). All systems are carried out in an air or nitrogen atmosphere, and visible light is utilized to excite a photosensitizer for catalyzation. In a reaction solvent, ArNR1R2 as shown in a formula (1) and water as shown in a formula (2) are used as reaction raw materials and react under the auxiliary action of acid to obtain the aryl phenol compound as shown in a formula (3). The ArNR1R2 in the formula (1) can be primary amine and tertiary amine, can also be steroid and amino acid derivatives, and can also be drugs or derivatives of propofol, paracetamol, ibuprofen, oxaprozin, indomethacin and the like. The synthesis method has the advantages of cheap and easily available raw materials, simple reaction operation, mild reaction conditions, high reaction yield and good compatibility of substrate functional groups. The fluid reaction not only can realize amplification of basic chemicals, but also can realize amplification of fine chemicals, such as synthesis of drugs propofol and paracetamol. The invention has wide application prospect and use value.