cas 152121-47-6, SB 203580 | Articles data

Articles about 152121-47-6Total 6 be found

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Treatment for CNS injuries
The present invention is directed to the use of 2,4,5-trisubstituted imidazole compounds and compositions in the treatment of CNS injuries to the brain.
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(2008/06/13)

Use of kinase inhibitors for treating neurodegenerative diseases
The present invention relates to methods of treating neurodegenerative diseases, including but not limited to Parkinson's disease. In particular, the present invention provides methods utilizing the administration of pyridyl imidazoles having simultaneous inhibitory activity towards p38 mitogen-activated protein (MAP) kinase and c-jun-N-terminal kinase (JNK). The present invention also provides methods for preventing apoptosis of dopamine neurons using pyridyl imidazoles. The present invention also provides methods for the treatment of neurodegenerative diseases, including but not limited to Parkinson's disease.
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(2008/06/13)

Pyrimidinyl imidazoles
Novel 2,4,5-triaryl imidazole compounds and compositions for use in therapy.
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(2008/06/13)

Imidazole derivatives and their use as cytokine inhibitors
As cytokine inhibitors 2,4,5-triarylimidazole compounds and compositions for use as cytokine inhibitors.
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(2008/06/13)

Regulation of stress-induced cytokine production by pyridinylimidazoles inhibition of CSBP kinase
Members of three classes of pyridinylimidazoles bind with varying affinities to CSBP (p38) kinase which is a member of a stress-induced signal transduction pathway. Based upon SAR and protein homology modeling, the pharmacophore and three potential modes of binding to the enzyme are presented. For a subset of pyridinylimidazoles, binding is shown to correlate with inhibition of CSBP kinase activity, whereas no significant inhibition of PKA, PKα and ERK kinase activity is observed.
Gallagher, Timothy F.,Seibel, George L.,Kassis, Shouki,Laydon, Jeffrey T.,Blumenthal, Mary Jane,Lee, John C.,Lee, Dennis,Boehm, Jeffrey C.,Fier-Thompson, Susan M.,Abt, Jeffrey W.,Soreson, Margaret E.,Smietana, Juanita M.,Hall, Ralph F.,Garigipati, Ravi S.,Bender, Paul E.,Erhard, Karl F.,Krog, Arnold J.,Hofmann, Glenn A.,Sheldrake, Peter L.,McDonnell, Peter C.,Kumar, Sanjay,Young, Peter R.,Adams, Jerry L.
p. 49 - 64
(2007/10/03)

Pyridyl imidazoles
Novel 2,4,5-triaryl imidazole compounds and compositions for use in therapy.
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(2008/06/13)

Chemical Properties

Appearance/Colour :White to off-white solid
Melting Point: 144-146
Boiling Point: 615.6 °C at 760 mmHg
Flash Point:326.1 °C
Density: 1.42 g/cm³
Solubility:DMSO: 50 mg/mL
Storage Temp.:−20°C
Vapor Pressure: 2E-14mmHg at 25°C
Refractive Index: 1.714
PKA: 9.60±0.10(Predicted)
PSA: 77.85000
LogP: 5.54790

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Chemical Properties

Appearance/Colour :White to off-white solid

Melting Point: 144-146

Boiling Point: 615.6 °C at 760 mmHg

Flash Point:326.1 °C

Density: 1.42 g/cm³

Solubility:DMSO: 50 mg/mL

Storage Temp.:−20°C

Vapor Pressure: 2E-14mmHg at 25°C

Refractive Index: 1.714

PKA: 9.60±0.10(Predicted)

PSA: 77.85000

LogP: 5.54790

Global suppliers and manufacturers of 152121-47-6total 103 suppliers on LookChem

Article Database

152121-47-6

Articles about 152121-47-6Total 6 be found

More Articles about upstream products of 152121-47-6

Chemical Properties

Appearance/Colour :White to off-white solid

Melting Point: 144-146

Boiling Point: 615.6 °C at 760 mmHg

Flash Point:326.1 °C

Density: 1.42 g/cm3

Solubility:DMSO: 50 mg/mL

Storage Temp.:−20°C

Vapor Pressure: 2E-14mmHg at 25°C

Refractive Index: 1.714

PKA: 9.60±0.10(Predicted)

PSA: 77.85000

LogP: 5.54790

Global suppliers and manufacturers of 152121-47-6total 103 suppliers on LookChem

Density: 1.42 g/cm³