- The Inophyllums, Novel Inhibitors of HIV-1 Reverse Transcriptase Isolated from the Malaysian Tree, Calophyllum inophyllum Linn
-
As part of a search for novel inhibitors of HIV-1 reverse transcriptase, the acetone extract of the giant African snail, Achatina fulica, was shown to be active. Fractionation of the extract yielded inophyllums A, B, C, and E and calophylloide (1a, 2a, 3a
- Patil, Ashok D.,Freyer, Alan J.,Eggleston, Drake S.,Haltiwanger, R. Curtis,Bean, Mark F.,et al.
-
-
Read Online
- New coumarins and triterpenes from Calophyllum inophyllum
-
Four new coumarins, 1-4, and two new triterpenes, 5 and 6, along with nine known compounds have been identified from the leaves of Calophyllum inophyllum on the basis of spectroscopic analyses and chemical methods. The structure of apetalolide (7), previously reported from C. apetalum, was revised by means of 2D-NMR, and the absolute configuration of the known compound inophyllum D (8) was established by a modified Mosher's method.
- Zou, Jian,Wu, Jian,Liu, Shuang-Zhu,Zhao, Wei-Min
-
-
Read Online
- Concise Synthesis of Anti-HIV-1 Active (+)-Inophyllum B and (+)-Calanolide A by Application of (-)-Quinine-Catalyzed Intramolecular Oxo-Michael Addition
-
(-)-Quinine-catalyzed intramolecular oxo-Michael addition (IMA) of 7-hydroxy-5-methoxy-8-tigloylcoumarins was developed for the enantioselective construction of 2,3-dimethyl-4-chromanone systems in the context of the asymmetric synthesis of anti-HIV-1 act
- Sekino, Etsuko,Kumamoto, Takuya,Tanaka, Tomohiro,Ikeda, Tomoko,Ishikawa, Tsutomu
-
p. 2760 - 2767
(2007/10/03)
-