- Preparation method of Elagolix intermediate 2-fluoro-6-trifluoromethyl benzylamine
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The invention discloses a preparation method of an Elagolix intermediate 2-fluoro-6-trifluoromethyl benzylamine, and belongs to the technical field of medical intermediates. The preparation method comprises the following steps: (1) synthesizing 2-fluoro-6-(trifluoromethyl) benzyl alcohol; (2) synthesizing 2-fluoro-6-(trifluoromethyl) benzyl alcohol; (3) synthesizing a 2-fluoro-6-(trifluoromethyl)benzenemethanesulfonate compound and a phthalimide compound; (4) directly synthesizing a phthalimide compound; (5) synthesizing the 2-fluorine-6-trifluoromethyl benzylamine. According to the preparation method, factors such as a reaction reagent and a reaction solvent are optimized, so the reaction conditions are mild, the technological process is simple and convenient, the requirements on equipment are relatively low, the price of raw materials is lower, the purity of the obtained product is high, and industrial production is facilitated.
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- Method for synthesizing Elagolix midbody polysubstituted pyrimidine derivate through two-step method
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The invention discloses a method for synthesizing an Elagolix midbody polysubstituted pyrimidine derivate through a two-step method. The method comprises the following steps that (1) (2-fluoro-6-(trifluoromethyl)phenyl)methylamine shown as a formula II re
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Page/Page column 6-10
(2019/06/11)
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