239087-06-0

Basic information

• Product Name: 2-FLUORO-6-(TRIFLUOROMETHYL)BENZYLAMINE
• Synonyms: 2-FLUORO-6-(TRIFLUOROMETHYL)BENZYLAMINE;2-Chloro-6-(trifluoroMethyl)benzylaMine, JRD, 97%;2-(Aminomethyl)-3-fluorobenzotrifluoride, [2-Fluoro-6-(trifluoromethyl)phenyl]methylamine;(2-fluoro-6-(trifluoroMethyl)phenyl)MethanaMine;(2-fluoro-6-(trifluoroMethyl)phenyl)MethanaMine hydrochloride;elagolix intermediate 1;1-[2-Fluoro-6-(trifluoromethyl)phenyl]methanamine;OTF-BYM-6F
• CAS NO: 239087-06-0
• Molecular Formula: C₈H₇F₄N
• Molecular Weight: 193.14
• Product Categories: Amine
• Mol File: 239087-06-0.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 173.161 °C at 760 mmHg
• Flash Point: 69.713 °C
• Appearance: /
• Density: 1.313 g/cm³
• Refractive Index: 1.4925
• Storage Temp.: Store under Nitrogen
• PKA: 7.84±0.10(Predicted)
• Sensitive: Air Sensitive
• CAS DataBase Reference: 2-FLUORO-6-(TRIFLUOROMETHYL)BENZYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-FLUORO-6-(TRIFLUOROMETHYL)BENZYLAMINE(239087-06-0)
• EPA Substance Registry System: 2-FLUORO-6-(TRIFLUOROMETHYL)BENZYLAMINE(239087-06-0)

Safety Data

• Hazard Codes: C
• Statements: 36/37/38
• Safety Statements: 26-36
• HazardClass: 8
• Hazardous Substances Data: 239087-06-0(Hazardous Substances Data)

Usage

Chemical Properties

Colorless to pale yellow liquid

Uses

(2-Fluoro-6-(trifluoromethyl)phenyl)methanamine Hydrochloride is used in preparation method and application of Elagolix intermediate and its salts.

InChI:InChI=1/C9H10F3N/c1-6-3-2-4-8(7(6)5-13)9(10,11)12/h2-4H,5,13H2,1H3

Upstream product

• 581072-15-3 2-fluoro-6-(trifluoromethyl)benzaldehyde oxime 
• 401-80-9 3-fluoro-trifluoromethylbenzene 
• 32890-94-1 2-fluoro-6-(trifluoromethyl)benzoic acid 
• 152211-15-9 (2-fluoro-6-(trifluoromethyl)phenyl)methanol 
• 643088-07-7 2-fluoro-6-(trifluoromethyl)benzylamine hydrochloride 
• 60611-24-7 2-fluoro-6-(trifluoromethyl)benzaldehyde 
• 133116-83-3 2-fluoro-6-(trifluoromethyl)benzonitrile 

Downstream Products

• 1150560-54-5 1-{[2-fluoro-6-(trifluoromethyl)phenyl]methyl}-5-iodo-6-methylpyrimidine-2,4(1H,3H)-dione 
• 1150560-59-0 5-(2-fluoro-3-methoxyphenyl)-1-{[2-fluoro-6-(trifluoromethyl)phenyl]methyl}-6-methylpyrimidine-2,4(1H,3H)-dione 
• 830346-47-9 1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methyl-2,4(1H,3H)-pyrimidinedione 
• 1454273-47-2 ethyl 8-benzyl-3-((2-fluoro-6-(trifluoromethyl)benzyl)amino)-1-oxa-8-azaspiro[4.5]dec-3-en-4-carboxylate 
• 830346-46-8 N-{[2-fluoro-6-(trifluoromethyl)phenyl]methyl}urea 

Relevant articles and documents

Preparation method of Elagolix intermediate 2-fluoro-6-trifluoromethyl benzylamine

The invention discloses a preparation method of an Elagolix intermediate 2-fluoro-6-trifluoromethyl benzylamine, and belongs to the technical field of medical intermediates. The preparation method comprises the following steps: (1) synthesizing 2-fluoro-6-(trifluoromethyl) benzyl alcohol; (2) synthesizing 2-fluoro-6-(trifluoromethyl) benzyl alcohol; (3) synthesizing a 2-fluoro-6-(trifluoromethyl)benzenemethanesulfonate compound and a phthalimide compound; (4) directly synthesizing a phthalimide compound; (5) synthesizing the 2-fluorine-6-trifluoromethyl benzylamine. According to the preparation method, factors such as a reaction reagent and a reaction solvent are optimized, so the reaction conditions are mild, the technological process is simple and convenient, the requirements on equipment are relatively low, the price of raw materials is lower, the purity of the obtained product is high, and industrial production is facilitated.

Method for preparing agomelatine intermediate (by machine translation)

The invention relates to a method for preparing an intermediate of agomelatine. The method is simple and convenient to E8 operate, mild E8 in condition and very suitable for industrial production C. (by machine translation)

PROCESSES TO PRODUCE ELAGOLIX

The present invention relates to a scalable process for the making of elagolix, its salts and the process of intermediate compounds.