152423-09-1

Basic information

• Product Name: 6-(4-chlorophenyl)pyrazolo[3,4-d][1,3]thiazolo[3,2-a]pyrimidin-4(1H)-one
• Synonyms: 6-(4-Chlorophenyl)pyrazolo[3,4-d][1,3]thiazolo[3,2-a]pyrimidin-4(1H)-one
• CAS NO: 152423-09-1
• Molecular Formula: C₁₃H₇ClN₄OS
• Molecular Weight: 302.7389
• Mol File: 152423-09-1.mol

Chemical Properties

• Boiling Point: 594.3°C at 760 mmHg
• Flash Point: 313.2°C
• Density: 1.74g/cm³
• Vapor Pressure: 4.31E-14mmHg at 25°C
• Refractive Index: 1.864
• CAS DataBase Reference: 6-(4-chlorophenyl)pyrazolo[3,4-d][1,3]thiazolo[3,2-a]pyrimidin-4(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6-(4-chlorophenyl)pyrazolo[3,4-d][1,3]thiazolo[3,2-a]pyrimidin-4(1H)-one(152423-09-1)
• EPA Substance Registry System: 6-(4-chlorophenyl)pyrazolo[3,4-d][1,3]thiazolo[3,2-a]pyrimidin-4(1H)-one(152423-09-1)

Safety Data

• Hazardous Substances Data: 152423-09-1(Hazardous Substances Data)

Upstream product

• 536-38-9 4-chlorobenzoylmethyl bromide 
• 152423-00-2 6-[2-(4-Chloro-phenyl)-2-oxo-ethylsulfanyl]-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one 
• 24521-76-4 6-thioxo-1,5,6,7-tetrahydropyrazolo<3,4-d>pyrimidin-4-one 

Relevant articles and documents

Pyrazolothiazolopyrimidine derivatives as a novel class of anti-inflammatory or antinociceptive agents: synthesis, structural characterization and pharmacological evaluation

As a part of a research program on anti-inflammatory-analgesic compounds, pyrazolothiazolopyrimidines 5a-f and 5g-i were prepared by cyclodehydration in 98percent H2SO4 or PPA of the corresponding 6-thioketomethylene-substituted-4-hydroxypyrazolopyrimidinies 2a-i and 2g-i.The results of the pharmacological in vivo screening indicate an interesting dissociation of the analgesic from the anti-inflammatory activity depending on aromatic or aliphatic substitution at C4 of the thiazole ring.Analgesic activity was not associated with any narcotic affect: in addition, all th e active compounds showed a remarkable systemic and gastric tolerance.This indicated a mode of action different from that of the classical nonsteroidal anti-inflammatory drugs, acting on prostaglandin biosynthesis.To clarify the mechanism or the mechanisms underlying the pharmacological activity of these and other closely related compounds, we initiated a 'file chemical approach' to various systems involved in the inflammatory process.At present, some of the more active in vivo compounds tested as substance P antagonists showed a moderate and possibly non-specific effect on NK1 and NK2 receptors. pyrazolothiazolopyrimidine derivatives / anti-inflammatory-analgesic activity / substance P antagonists