152580-30-8

Basic information

• Product Name: 2(3H)-Furanone,4-aminodihydro-,(S)-(9CI)
• Synonyms: 2(3H)-Furanone,4-aminodihydro-,(S)-(9CI);(4S)-4-aminodihydro-2(3H)-Furanone;S-2(3H)-Furanone, 4-aminodihydro-
• CAS NO: 152580-30-8
• Molecular Formula: C4H7NO2
• Molecular Weight: 101.1
• Product Categories: VARIOUSAMINE
• Mol File: 152580-30-8.mol

Chemical Properties

• Boiling Point: 257.1±33.0 °C(Predicted)
• Appearance: /
• Density: 1.206±0.06 g/cm3(Predicted)
• PKA: 6.38±0.20(Predicted)
• CAS DataBase Reference: 2(3H)-Furanone,4-aminodihydro-,(S)-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2(3H)-Furanone,4-aminodihydro-,(S)-(9CI)(152580-30-8)
• EPA Substance Registry System: 2(3H)-Furanone,4-aminodihydro-,(S)-(9CI)(152580-30-8)

Safety Data

• Hazardous Substances Data: 152580-30-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
2(3H)-Furanone,4-aminodihydro-,(S)-(9CI) is used as a key intermediate in the synthesis of various pharmaceuticals and agrochemicals due to its versatile reactivity and functional groups. Its chiral nature allows for the creation of enantiomerically pure compounds, which is crucial for the development of effective and selective drugs and pesticides.
Used in Fragrance and Flavor Industries:
2(3H)-Furanone,4-aminodihydro-,(S)-(9CI) is used as a fragrance and flavor ingredient for its pleasant aroma. Its unique scent profile makes it suitable for incorporation into a wide range of consumer products, including perfumes, cosmetics, and food products, to enhance their sensory appeal.
Used in Research and Development:
2(3H)-Furanone,4-aminodihydro-,(S)-(9CI) is utilized in research and development for exploring its potential biological activities. Studies have focused on its antimicrobial properties, which could lead to the development of new antibiotics or antifungal agents. Additionally, its antitumor properties are being investigated for possible applications in cancer treatment and therapy.

Upstream product

• 87219-29-2 benzyl (3S)-5-oxotetrahydro-3-furanylcarbamate 
• 127560-92-3 (R,S)-4-benzylamino-4,5-dihydro-2(3H)-furanone 
• 98063-21-9 Emeriamine 
• 118399-28-3 (R)-4-benzyloxycarbonylamino-4,5-dihydro-2(3H)-furanone 

Downstream Products

• 1421583-00-7 4-(5-{(1R)-1-[4-(cyclopropylcarbonyl)phenoxy]propyl}-1,2,4-oxadiazol-3-yl)-2-fluoro-N-[(3S)-5-oxotetrahydrofuran-3-yl]benzamide 

Relevant articles and documents

Kras inhibitory cyclic peptide compound

The following were discovered: a cyclic peptide compound that interacts with Ras; and an unnatural amino acid that is useful in the production of said cyclic peptide compound. The cyclic peptide compound was also discovered to inhibit bonding between Ras and SOS. The following were additionally discovered: a specific unnatural amino acid included in said cyclic peptide compound; and a manufacturing method therefor.

N-HETERO-RING-SUBSTITUTED AMIDE DERIVATIVE

Compounds are provided having an excellent hypoglycemic effect and β cell- or pancreas-preserving effects or pharmaceutically acceptable salts thereof, and a pharmaceutical composition having an excellent therapeutic effect and/or prophylactic effect on type 1 diabetes, type 2 diabetes, and the like, which cause hyperglycemia due to abnormal glucose metabolism. A compound represented by general formula (I), or a pharmaceutically acceptable salt thereof, is disclosed.

N-substituted 4-amino-3,3-dipropyl-2(3H)-furanones: New positive allosteric modulators of the GABAA receptor sharing electrophysiological properties with the anticonvulsant loreclezole

1,4-Addition of benzylamine to 2(5H)-furanone followed by dialkylation of the 3-position with allylbromide gave (±)-4-benzyl-3,3-diallyl-2(3H)-furanone (8), which served as the intermediate for the synthesis of various N-substituted 4-amino-3,3-dipropyl-2

Single Step Conversion of Chiral Carnitine and Derivatives into (S)- and (R)-β-Substituted-γ-Butyrolactones

This paper describes an efficient single step transformation of chiral carnitine and carnitine derivatives into stereoisomerically pure (S)- and (R)-β-substituted-γ-butyrolactones, obtained by intramolecular nucleophilic displacement. (S)- Or (R)-carnitine and (R)-aminocarnitine inner salts give β-hydroxy-γ-butyrolactone and β-amino-γ-butyrolactone respectively (82% and 77%) with the same configuration as the starting material. (R)-Acetylaminocarnitine inner salt gives (R)-β-acetylamino-γ-butyrolactone (90%), while (R)-acetylcarnitine gives 2(5H)-furanone under the same reaction conditions (77%, via cyclization and subsequent elimination reaction). (R)-N-Benzyloxycarnitineamide gives a mixture of pyrrolidinone (11%) and furanoyl imidate (50%) derivatives. The direct transformation of waste (S)-carnitine into the valuable (S)-β-hydroxy-γ-butyrolactone or (after acetylation) into the precious 2(5H)-furanone is of particular interest.