- New α-aryl-β,N-imidazolylethyl benzyl and naphthylmethyl ethers with antimycotic and antibacterial activity
-
A new series of α-aryl-β,N-imidazolylethyl benzyl and naphthylmethyl ethers was synthesized and tested for antimycotic and antimicrobial activity. All compounds showed antifungal activity; most of them were also active against gram-positive bacteria, whereas no activity was detected against gram-negative bacteria. Structure-activity relationships are discussed. The α-(2,4-dichlorophenyl)-β,N-imidazolylethyl 4-phenylthiobenzyl ether nitrate (8), which showed good ski tolerability and in vivo antimycotic activity comparable with or better than 1-[2,4-dichloro-β-(2,4-dichlorobenzyloxy)phenethyl]imidazole (miconazole) and 1-[α-(o-chlorophenyl)benzhydryl]imidazole (clotrimazole), was selected for further researches.
- Nardi,Cappelletti,Catto,Leonardi,Tajana,Veronese
-
p. 2123 - 2126
(2007/10/02)
-
- Physico-chemical, structural and analytical studies on fenticonazole, a new drug with antimycotic properties
-
Physico-chemical properties and methods for the detection and the determination of a new potent antimycotic compound, the α-(2,4-dichlorophenyl)-β-N-imidazolyethyl-4-phenylthiobenzyl ether nitrate (fenticonazole, Rec 15/1476) and its potential impurities are reported. TLC, GC, and HPLC were the analytical techniques employed.
- Tajana,Sibilia,Cappelletti,Cova,Nardi
-
p. 2127 - 2133
(2007/10/02)
-