15291-78-8Relevant articles and documents
CORE-MODIFIED TERPENE TRILACTONES FROM GINKGO BILOBA EXTRACT AND BIOLOGICAL EVALUATION THEREOF
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Page/Page column 115-116; sheet 25/29, (2008/06/13)
Lactone-rings of ginkgolides are converted into the corresponding tetrahydrofuran moieties via DIBAL-H reduction followed by deoxygenation of the formed lactols with Et3SiH/BF3Et2O producing a series of lactol-free ginkgol
A concise synthesis of ginkgolide M, a minor component of a terpene trilactone fraction from Ginkgo biloba roots
Bolshakov, Sergei,Dzyuba, Sergei V.,Decatur, John,Nakanishi, Koji
, p. 429 - 431 (2008/09/19)
Ginkgolide M (GM), which is found only in the roots of the Ginkgo biloba tree and is an inhibitor of ligand-operated ion channels in the central nervous system, has been prepared in three steps from 10-benzylginkgolide C, an intermediate generated during the isolation and separation of ginkgolides from Ginkgo biloba leaf extract. The described synthetic sequence can be applied to access GM derivatives for biological studies.
Chemistry of the Ginkgolides, VI. - Preparation of 1,10-Dihydroxy- and 1,7,10-Trihydroxyginkgolide from 1,3,7,10-Tetrahydroxyginkgolide
Weinges, Klaus,Ruemmler, Matthias,Schick, Hartmut
, p. 1023 - 1028 (2007/10/02)
1,3,7,10-Tetrahydroxyginkgolide ("ginkgolide C", 1) which can be isolated in large quantities from the terpene fraction of Ginkgo leaves, can be converted into 1-(tert-butyldiphenylsilyloxy)-3,7,10-trihydroxyginkgolide (2) in 95percent yield. 2 was conver
