15291-76-6 Usage
Description
Ginkgolide C is a flavone first extracted from G. biloba leaves with multiple reported biological functions. It has been identified as a selective platelet activating factor receptor antagonist (IC50 = 37.6 μM). Ginkgolide C has also been shown to increase lipolysis and to inhibit adipogenesis in adipocytes via the activated AMPK pathway. It is a crystalline solid.
Uses
Used in Pharmaceutical Industry:
Ginkgolide C is used as a reference compound for PAF receptors in biological systems, making it a valuable tool for research and development in the pharmaceutical industry.
Used in Cardiovascular and Cerebrovascular Treatments:
Ginkgolide C is used as a family of bioactive terpenes for treating cardiovascular and cerebrovascular diseases. It acts as a specific platelet activating factor (PAF) antagonist, which can help in the treatment and management of these conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 15291-76-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,5,2,9 and 1 respectively; the second part has 2 digits, 7 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 15291-76:
(7*1)+(6*5)+(5*2)+(4*9)+(3*1)+(2*7)+(1*6)=106
106 % 10 = 6
So 15291-76-6 is a valid CAS Registry Number.
InChI:InChI=1/C20H24O11/c1-5-12(24)28-11-8(22)18-10-6(21)7(16(2,3)4)17(18)9(23)13(25)30-15(17)31-20(18,14(26)29-10)19(5,11)27/h5-11,15,21-23,27H,1-4H3/t5-,6-,7+,8?,9?,10-,11+,15+,17?,18?,19-,20+/m1/s1
15291-76-6Relevant articles and documents
Isolation of ginkgolides A, B, C, J and bilobalide from G. biloba extracts
Jaracz, Stanislav,Malik, Shahid,Nakanishi, Koji
, p. 2897 - 2902 (2004)
Ginkgolides A, B, C and J, together with bilobalide, are unique terpenoid components of the Ginkgo biloba tree. Due to similar chemical properties, their separation is quite tedious. We have developed an efficient and rapid protocol for separation of individual ginkgolides and bilobalide from G. biloba extracts. The procedure takes advantage of enhanced susceptibility of ginkgolides B and C to benzylation and the ease of separation of these products from ginkgolides A and J which do not react. The protocol is applicable to the previously reported enriched extracts prepared from G. biloba leaves. A single chromatographic step prior to benzylation provides bilobalide and mixture of ginkgolides A, B, C, and J. After benzylation, the individual ginkgolides are separated by chromatography.