153108-65-7Relevant articles and documents
Synthesis method of 5-methyl-5-hydroxy-1-azabicyclo[4.4.0] decane-2-one
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Paragraph 0038; 0043-0046, (2020/10/04)
The invention discloses a synthetic method of 5-methyl-5-hydroxy-1-azabicyclo[4.4.0]decane-2-one, and belongs to the technical field of organic synthesis. The method comprises the following steps: reacting (S)-1-(tert-butyloxycarbonyl)-2-piperidine carboxylic acid adopted as an initial raw material with N,O-dimethyl hydroxylamine hydrochloride to obtain a carbamoyl piperidine intermediate, then carrying out a Grignard reaction to obtain an acetyl piperidine intermediate, then carrying out a Grignard reaction, Boc protection removal and acylation to obtain a diene ring closed precursor, and finally carrying out an olefin metathesis reaction and a hydrogenation reaction to obtain a target product. Two diastereoisomers in the product are split by the preparative liquid chromatography, and thesequence of removing Boc protecting groups is different, so that the dominant spatial configuration control of the diastereoisomers is realized, and the method provides a powerful technical support for the total synthesis of related natural products.
COMPOUNDS, COMPOSITIONS AND METHODS FOR SYNTHESIS
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Paragraph 00679; 00680; 00683; 00684, (2019/01/10)
The present disclosure, among other things, provides technologies for synthesis, including reagents and methods for stereoselective synthesis. In some embodiments, the present disclosure provides compounds useful as chiral auxiliaries. In some embodiments, the present disclosure provides reagents and methods for oligonucleotide synthesis. In some embodiments, the present disclosure provides reagents and methods for chirally controlled preparation of oligonucleotides. In some embodiments, technologies of the present disclosure are particularly useful for constructing challenging internucleotidic linkages, providing high yields and stereoselectivity.
Highly stereoselective total syntheses of (+)-allopumiliotoxins 267A and 339A via intramolecular nickel(II)/chromium(II)-mediated cyclization
Aoyagi, Sakae,Wang, Tzu-Chueh,Kibayashi, Chihiro
, p. 11393 - 11409 (2007/10/02)
Remarkably high regio- and stereoselective approaches for the syntheses of dendrobatid alkaloids (+)allopumiliotoxin 267A and 339A have been develop. As a model study for these alkaloids, we initially undertook intramolecular chromium(II)-mediated cycliza
