153199-54-3Relevant articles and documents
A concise approach towards the synthesis of WS75624 a and WS75624 B via the cross-metathesis of vinyl-functionalized thiazoles
Dash, Jyotirmayee,Melillo, Bruno,Arseniyadis, Stellios,Cossy, Janine
scheme or table, p. 2246 - 2249 (2011/05/05)
Synthetic approach towards precursors of WS75624 A and WS75624 B, two potent endothelin converting enzyme (ECE) inhibitors and potential antihypertensive agents, is reported featuring a key cross-metathesis between a vinyl-functionalized thiazole and a terminal olefin. As the two natural products only differ by the nature of their hydroxyalkyl side-chain, our convergent strategy enable the synthesis of key intermediates of both molecules in a limited amount of steps.
Total synthesis of the antifungal dilactones UK-2A and UK-3A: The determination of their relative and absolute configurations, analog synthesis and antifungal activities
Shimano, Masanao,Kamei, Noriyuki,Shibata, Tetsuo,Inoguchi, Kiyoshi,Itoh, Nobuko,Ikari, Takashi,Senda, Hisato
, p. 12745 - 12774 (2007/10/03)
The synthesis of the antifungal dilactones, UK-2A and UK-3A, is described. In addition to providing a workable synthetic route to these potent antifungal antibiotics, this has allowed us to determine the assignment of the relative and absolute configurations in the nine-membered ring. Furthermore, UK-2A analogs were also synthesized and evaluated their antifungal activities and cytotoxic activities along with UK-2A, (2R, 3R, 4S, 7R)-UK-2A, UK-3A, (2R, 3R, 4S, 7R)-UK-3A, and antimycin A. The structural requirements for the selective cytotoxicity against yeasts and filamentous fungi will also be suggested.
New Synthesis of Orelline by Metalation of Methoxypyridines
Trecourt, Francois,Mallet, Marc,Mongin, Olivier,Gervais, Bruno,Queguiner, Guy
, p. 8373 - 8380 (2007/10/02)
A new total synthesis in five steps of alkaloid Orelline is reported.The methodology involves metalation of methoxypyridines to afford 2-halo-3,4-dimethoxypyridine on which an homocoupling reaction is performed to build the 2,2'-bipyridyl structure of the