- Ruthenium(ii)-catalysed 1,2-selective hydroboration of aldazines
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Herein, an efficient and simple catalytic method for the selective and partial reduction of aldazines using ruthenium catalyst [Ru(p-cymene)Cl2]2 (1) has been accomplished. Under mild conditions, aldazines undergo the addition of pinacolborane in the presence of a ruthenium catalyst, which delivered N-boryl-N-benzyl hydrazone products. Notably, the reaction is highly selective, and results in exclusive mono-hydroboration and desymmetrization of symmetrical aldazines. Mechanistic studies indicate the involvement of in situ formed intermediate [{(η6-p-cymene)RuCl}2(μ-H-μ-Cl)] (1a) in this selective hydroboration.
- Gunanathan, Chidambaram,Pradhan, Subham,Thiyagarajan, Subramanian
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supporting information
p. 7147 - 7151
(2021/08/30)
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- An expeditious synthetic approach towards the synthesis of Bis-Schiff bases (aldazines) using ultrasound
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Aldazines (Bis-Schiff bases) 1-24 were synthesized using aromatic aldehydes (heterocyclic and benzaldehydes) and hydrazine hydrate under reflux using conventional heating and/or via ultrasound irradiation using BiCl3 as catalyst. Ultrasonication conditions with cat. BiCl3 proved to be an effective, environmentally friendly synthetic procedure. This methodology is robust in the presence of electron donating and electron withdrawing groups affording desired products with high yields (>95%) in just a couple of minutes vs. hours using conventional heating.
- Khan, Khalid M.,Jamil, Waqas,Ambreen, Nida,Taha, Muhammad,Perveen, Shahnaz,Morales, Guillermo A.
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p. 1200 - 1205
(2014/02/14)
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- A family of highly selective allosteric modulators of the metabotropic glutamate receptor subtype 5
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We have identified a family of highly selective allosteric modulators of the group I metabotropic glutamate receptor subtype 5 (mGluR5). This family of closely related analogs exerts a spectrum of effects, ranging from positive to negative allosteric modu
- O'Brien, Julie A.,Lemaire, Wei,Chen, Tsing-Bau,Chang, Raymond S. L.,Jacobson, Marlene A.,Ha, Sookhee N.,Lindsley, Craig W.,Schaffhauser, Herve J.,Sur, Cyrille,Pettibone, Douglas J.,Conn, P. Jeffrey,Williams Jr., David L.
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p. 731 - 740
(2007/10/03)
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