- A preparation method of Ginkgolide K
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The invention discloses a method for preparing ginkgolide K. The method includes the following steps: 1, ginkgolide B is dissolved into organic solvents to obtain a solution; 2, fluorinating agents are added into the solution obtained in the step 1 for conducting a dehydration reaction, and the ginkgolide K is obtained through separation and purification. The method for preparing the ginkgolide K is easy to operate; meanwhile, the high yield and the high purity are achieved, and convenience is brought to industrialization large-scale production. (please see the specification for the formula).
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Paragraph 0038-0039; 0044-0049; 0051; 0052
(2018/09/12)
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- Ginkgolide K derivative and its preparation and use
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The invention discloses a bilobalide K derivative and a preparation method and application thereof according to the formula I. Since structural modification is performed on bilobalide K, the bilobalide K derivative with higher water solubility and higher activity can be obtained and applied to prevention and treatment of cardiovascular and cerebrovascular diseases. Meanwhile, the bilobalide K derivative preparation process is facilitated and is adaptive to industrial production. (img file = 'DDA0000748217710000011.TIF' wi = '595' he = '515' /).
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Paragraph 0056-0057
(2018/06/14)
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- A concise synthesis of ginkgolide M, a minor component of a terpene trilactone fraction from Ginkgo biloba roots
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Ginkgolide M (GM), which is found only in the roots of the Ginkgo biloba tree and is an inhibitor of ligand-operated ion channels in the central nervous system, has been prepared in three steps from 10-benzylginkgolide C, an intermediate generated during the isolation and separation of ginkgolides from Ginkgo biloba leaf extract. The described synthetic sequence can be applied to access GM derivatives for biological studies.
- Bolshakov, Sergei,Dzyuba, Sergei V.,Decatur, John,Nakanishi, Koji
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p. 429 - 431
(2008/09/19)
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- Chemistry of the Ginkgolides, VI. - Preparation of 1,10-Dihydroxy- and 1,7,10-Trihydroxyginkgolide from 1,3,7,10-Tetrahydroxyginkgolide
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1,3,7,10-Tetrahydroxyginkgolide ("ginkgolide C", 1) which can be isolated in large quantities from the terpene fraction of Ginkgo leaves, can be converted into 1-(tert-butyldiphenylsilyloxy)-3,7,10-trihydroxyginkgolide (2) in 95percent yield. 2 was conver
- Weinges, Klaus,Ruemmler, Matthias,Schick, Hartmut
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p. 1023 - 1028
(2007/10/02)
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